Insulin sensitivity in subacute experimental T3 hyperthyroidism in man.

The present study was planned to evaluate the effect of 3-day T3 administration on hepatic glucose production, peripheral glucose utilisation, insulin binding and pancreatic responsitivity. Three-day administration of T3 in healthy subjects increased plasma T3 concentration at the level commonly observed in hyperthyroid patients, even though plasma T4 was not increased. This condition of subacute experimental T3-hyperthyroidism produced a significant increase in fasting glucose turnover and a decrease in insulin-binding on circulating monocytes