The Role of Cities and Urbanisation in Achieving Development Goals

The world is in the midst of a long and uneven urban transition, with the great majority of urbanisation and urban population growth now occurring in parts of Asia and Africa. Urbanisation has profound effects on local rural and urban economies, life chances and environments, though much depends on how it is handled. The stereotypical view is that cities and urbanisation are economically advantageous but socially and environmentally deleterious. This Evidence Report follows other recent research in contradicting this oversimplified view. It explores how urbanisation and cities can contribute to the three global goals identified by the Institute of Development Studies (IDS) as priorities for the post-2015 period: (1) reducing economic inequalities; (2) creating more secure and inclusive societies; and (3) accelerating the transition to sustainability.UK Department for International Developmen

Multiple Instance Learning for Heterogeneous Images: Training a CNN for Histopathology

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an image-level classification by using the quantile function. The quantile function provides a more complete description of the heterogeneity within each image, improving image-level classification. We also adapt image augmentation to the MI framework by randomly selecting cropped regions on which to apply MI aggregation during each epoch of training. This provides a mechanism to study the importance of MI learning. We validate our method on five different classification tasks for breast tumor histology and provide a visualization method for interpreting local image classifications that could lead to future insights into tumor heterogeneity

Inclusive Urbanisation and Cities in the Twenty-First Century

In academic and policy discourse, urbanisation and cities are currently receiving a great deal of attention, and rightly so. Both have been central to the enormous transformation the world has been going through during the past few centuries. Many parts of the world have experienced and are experiencing an urban transformation. While these processes have taken distinct regional forms across Latin America, East and South Asia, and Africa, it is clear that, globally, the urban transformation has coincided with major societal and ecological changes. Some of these developments have been heralded as progress – notably millions of people being lifted out of poverty – while others, such as entrenching inequalities and accelerating climate change, are alarming. In recent years the pro-urban voices have been louder, but accounts of the wonders of cities need to be balanced with a recognition of the violence, inequity and environmentally destructive forces that cities can embody and reproduce. Equally important is to explore how cities and urbanisation can be made to contribute more to human wellbeing and to international and local development goals. This report is particularly concerned with whether and under what conditions more inclusive urbanisation and cities can support these development goals.UK Department for International Developmen

The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin

BACKGROUND: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free human epidermis. MATERIAL AND METHODS: We deeply sequenced 46 genes in normal skin biopsies from 127 healthy donors, from which phenotypic data (including age, pigmentation-related genotype and phenotype) and sun exposure habits were collected. We determined the somatic mutational burden, mutational signatures, clonal selection and frequency of driver mutations in all samples. RESULTS: Our results reveal an exponential accumulation of UV-related somatic mutations with age, matching skin cancer incidence. The increase of mutational burden is in turn modified by an individual's skin phototype. Somatic mutations preferentially accumulated in cutaneous squamous cell carcinoma (cSCC) cancer genes and clonally expanded with age, with distinct mutational processes underpinning different age groups. Our results suggest loss of fidelity in transcription-coupled repair later in life. CONCLUSION: Our findings reveal that aging is not only associated with an exponential increase in the number of somatic mutations accumulated in normal epidermis, but also with selection and expansion of cancer-associated mutations. Aged, sun-exposed normal skin is thus an extended mosaic of multiple clones with driver mutations, poised for the acquisition of transforming events

Climate Information for Improved Planning and Management of Mega Cities (Needs Perspective)

The majority of the population of the planet (6.6 billion) now live in urban areas, which have distinct impacts upon climate at scales from the local to the global. This urban effect is due to the physical form of the city (its three-dimensional geometry and material composition) and its functions (the day-to-day activity patterns that generate emissions of waste heat and materials into the overlying air). While a substantial body of knowledge on the science of urban climates has been developed over the past fifty years, there is little evidence that this knowledge is incorporated into urban planning and design practice. This paper focuses on this gap by examining the nature of urban climate expertise and the needs of those that make decisions about urban areas. In conclusion it makes recommendations to maintain and enhance urban observations and data; to improve understanding of local, regional and global climate linkages; to develop tools for practical planning; and to disseminate urban climate knowledge and its relevance to urban planning to both practicing meteorologists and urban decision makers

The effect of photoaging on the accumulation of somatic mutations in cancer-free human skin

This is a pre-print of an article published in Annals of Oncology. The final authenticated version is available online at: https://doi.org/10.1016/j.annonc.2020.11.023Background: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free human epidermis. Material and methods: We deeply sequenced 46 genes in normal skin biopsies from 123 healthy donors, from which phenotypic data (including age, pigmentation-related genotype and phenotype) and sun exposure habits were collected. We determined the somatic mutational burden, mutational signatures, clonal selection and frequency of driver mutations in all samples. Results: Our results reveal an exponential accumulation of UV-related somatic mutations with age, matching skin cancer incidence. The increase of mutational burden is in turn modified by an individual's skin phototype. Somatic mutations preferentially accumulated in cutaneous squamous cell carcinoma cancer genes and clonally expanded with age, with distinct mutational processes underpinning different age groups. Our results suggest a loss of fidelity in transcription-coupled repair later in life. Conclusion: Our findings reveal that ageing is not only associated with an exponential increase in the number of somatic mutations accumulated in normal epidermis, but also with selection and expansion of cancer-associated mutations. Aged, sun-exposed normal skin is thus an extended mosaic of multiple clones with driver mutations, poised for the acquisition of transforming events

With and beyond the state -- co-production as a route to political influence, power and transformation for grassroots organizations

This paper reviews the use of co-production – with state and citizensworking together – as a grassroots strategy to secure political infl uence and accessresources and services. To date, the literature on social movements has concentratedon more explicitly political strategies used by such movements to contest forpower and infl uence. Co-production, when considered, is viewed as a strategy usedby citizens and the state to extend access to basic services with relatively littleconsideration given to its wider political ramifi cations. However, co-productionis used increasingly by grassroots organizations and federations as part of anexplicit political strategy. This paper examines the use of co-productive strategiesby citizen groups and social movement organizations to enable individualmembers and their associations to secure effective relations with state institutionsthat address both immediate basic needs and enable them to negotiate for greaterbenefits.ESRC-DFI

Resilience as a policy narrative: potentials and limits in the context of urban planning

The aim of this paper is to analyse the emergence of the concept of ‘urban resilience’ in the literature and to assess its potentials and limitations as an element of policy planning. Using a systematic literature review covering the period 2003–2013 and a combination of techniques derived from narrative analysis, we show that diverse views of what urban resilience means and how it is best used (as a goal or as a conceptual/analytical framework) compete in the literature. Underlying these views are various (and sometimes diverging) interpretations of what the main issues are and what forms of policies or interventions are needed to address these issues. Urban planners need to be better aware of these different interpretations if they want to be in a position to use resilience appropriately and spell out what resilience can bring to their work. The review also highlights that the notion of urban resilience often lacks adequate acknowledgement of the political economy of urbanization and consequently does not challenge the status quo which, some argue, is socially unjust and environmentally unsustainable. As such it runs the risk to be seen as simply making marginalized urban communities more resilient to the shocks and inequity created by the current dominant paradigm

Interventions to improve perinatal outcomes among migrant women in high-income countries: a systematic review protocol

INTRODUCTION: Women who are migrants and who are pregnant or postpartum are at high risk of poorer perinatal outcomes compared with host country populations due to experiencing numerous additional stressors including social exclusion and language barriers. High-income countries (HICs) host many migrants, including forced migrants who may face additional challenges in the peripartum period. Although HICs' maternity care systems are often well developed, they are not routinely tailored to the needs of migrant women. The primary objective will be to determine what interventions exist to improve perinatal outcomes for migrant women in HICs. The secondary objective will be to explore the effectiveness of these interventions by exploring the impact on perinatal outcomes. The main outcomes of interest will be rates of preterm birth, birth weight, and number of antenatal or postnatal appointments attended. METHODS AND ANALYSIS: This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols guidelines. EMBASE, EMCARE, MEDLINE and PsycINFO, CENTRAL, Scopus, CINAHL Plus, and Web of Science, as well as grey literature sources will be searched from inception up to December 2022. We will include randomised controlled trials, quasi-experimental and interventional studies of interventions, which aim to improve perinatal outcomes in any HIC. There will be no language restrictions. We will exclude studies presenting only qualitative outcomes and those including mixed populations of migrant and non-migrant women. Screening and data extraction will be completed by two independent reviewers and risk of bias will be assessed using the Quality Assessment Tool for Quantitative Studies. If a collection of suitably comparable outcomes is retrieved, we will perform meta-analysis applying a random effects model. Presentation of results will comply with guidelines in the Cochrane Handbook of Systematic Reviews of Interventions and the PRISMA statement. ETHICS AND DISSEMINATION: Ethical approval is not required. Results will be submitted for peer-reviewed publication and presented at national and international conferences. The findings will inform the work of the Lancet Migration European Hub. PROSPERO REGISTRATION NUMBER: CRD42022380678

The impact of mental health recovery narratives on recipients experiencing mental health problems: Qualitative analysis and change model.

BACKGROUND: Mental health recovery narratives are stories of recovery from mental health problems. Narratives may impact in helpful and harmful ways on those who receive them. The objective of this paper is to develop a change model identifying the range of possible impacts and how they occur. METHOD: Semi-structured interviews were conducted with adults with experience of mental health problems and recovery (n = 77). Participants were asked to share a mental health recovery narrative and to describe the impact of other people's recovery narratives on their own recovery. A change model was generated through iterative thematic analysis of transcripts. RESULTS: Change is initiated when a recipient develops a connection to a narrator or to the events descripted in their narrative. Change is mediated by the recipient recognising experiences shared with the narrator, noticing the achievements or difficulties of the narrator, learning how recovery happens, or experiencing emotional release. Helpful outcomes of receiving recovery narratives are connectedness, validation, hope, empowerment, appreciation, reference shift and stigma reduction. Harmful outcomes are a sense of inadequacy, disconnection, pessimism and burden. Impact is positively moderated by the perceived authenticity of the narrative, and can be reduced if the recipient is experiencing a crisis. CONCLUSIONS: Interventions that incorporate the use of recovery narratives, such as peer support, anti-stigma campaigns and bibliotherapy, can use the change model to maximise benefit and minimise harms from narratives. Interventions should incorporate a diverse range of narratives available through different mediums to enable a range of recipients to connect with and benefit from this material. Service providers using recovery narratives should preserve authenticity so as to maximise impact, for example by avoiding excessive editing