Abandoning the idealized white subject of legal feminism: A manifesto for silence in a Lusophone register

Through an account of white feminisms and white privilege, this article examines the tensions between local and international knowledge frames. The article considers the possibility of a feminist approach to global constitutionalism and argues for a twofold critique: first, a feminist interrogation of the dominance of a specifically male history of Western and Anglo-European knowledge frames; and second, a self-critique within feminist approaches to global legal regimes that acknowledges the complicity of mainstream feminist tools in the racist histories of knowledge production. To this end, the article examines the space of gender expertise to explore how this can be both an aperture for plural feminist encounters and a refinement of diverse feminist approaches into a form digestible by the contours of international institutions. To explore alternative, decolonized encounters, the article centres Lusophone African feminist silence and action in Luanda, the capital of Angola. The article explores how Angolan gender relations, informal labour and histories of protest unsettle the frame of a feminist manifesto, to argue for a place for active silence as a methodology for undoing the status quo of global constitutional expectations of how knowledge arrives at the global and transnational levels

Determination of trace elements in the plants of Mt. Bozdag, Izmir, Turkey

The aim of this study was to determine the current level of atmospheric heavy metal content on the Bozdag Mountain of the Aegean Region, Turkey. Twenty nine different plants were selected to study their potential as biomonitors of trace elements such as Ni, Zn, Fe, Pb, Mn and Cd (μg g-1, dry weight). The samples were collected from two different altitudes of Mt. Bozdag. The concentrations of trace elements were determined by atomic absorption spectrometry. The mean concentrations determined at 1000 m altitude ranged from 0.025 to 1.609, 0.232 to 0.731, 0.578 to 5.983, 0.287 to 0.565 and 0.176 to 2.659 (μg g-1, dry weight), for Ni, Zn, Fe, Pb and Mn, respectively. At the altitude of 1600 m, the values ranged from 0.023 to 0.939, 0.258 to 1.254, 0.839 to 5.176, 0.301 to 1.341 and 0.405 to 3.351 (μg g-1, dry weight) for Ni, Zn, Fe, Pb and Mn, respectively. No Cd was detected at either altitude. Statistical significance was determined by the independent sample t-test and comparisons were made in order to determine if there were any differences between the averages of herbaceous and woody plants.

Molar-Incisor hypomineralization in controls vs CLP with primary or prior to secondary alveolar grafts

poster abstractMolar incisor hypomineralization (MIH) is a congenital defect of unknown etiology that can affect both esthetics and cariogenic susceptibility. The objective of this study was to determine whether MIH is greater in patients with cleft lip and palate (CLP) who underwent primary alveolar grafting (PAG) as compared to CLP prior to secondary alveolar grafting (SAG) and to controls. A retrospective analysis of intraoral photographs of 13 (10M:3F; 8.9 ± 1.2 yrs) CLP patients who underwent a PAG, 27 (18M:9F;10.0 ± 2.1 yrs) CLP prior to SAG, and 60 (30M:30F; 12.4 ± 1.8 yrs) controls without CLP was performed. Mantel-Haenszel chi-square tests were used to compare the three groups for differences in MIH scores and Wilcoxon Rank Sum tests were used to compare the groups for differences in average MIH scores. A 5% significance level was used for all tests. MIH scores were significantly higher for the PAG and SAG groups compared to the control group (p<0.001). The PAG group had significantly higher incisor MIH (p=0.016) than the SAG group. MIH average scores were significantly higher for the two graft groups compared to the controls (p<0.0001). The PAG group had significantly higher average MIH score and average MIH score for incisors than the SAG group (p=0.03). The results suggest that CLP patients, in general, have significantly greater MIH compared with controls and CLP with PAGs have significantly greater MIH in the incisor region than CLP waiting for SAGs. The increased severity of MIH could be related to the grafting during the time of incisor crown formation

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Using the stated preference method for the calculation of social discount rate

The aim of this paper is to build the stated preference method into the social discount rate methodology. The first part of the paper presents the results of a survey about stated time preferences through pair-choice decision situations for various topics and time horizons. It is assumed that stated time preferences differ from calculated time preferences and that the extent of stated rates depends on the time period, and on how much respondents are financially and emotionally involved in the transactions. A significant question remains: how can the gap between the calculation and the results of surveys be resolved, and how can the real time preferences of individuals be interpreted using a social time preference rate. The second part of the paper estimates the social time preference rate for Hungary using the results of the survey, while paying special attention to the pure time preference component. The results suggest that the current method of calculation of the pure time preference rate does not reflect the real attitudes of individuals towards future generations

Three-dimensional airway volumes and most constricted areas in children

poster abstractObjective: The objectives of this retrospective study using cone beam computed tomography (CBCT) were to determine if there are differences in the volume of various airway segments and the most constricted area (MCA) of children with different dentoskeletal patterns. Methods: The initial CBCTs of 83 orthodontic patients (30 Angle’s Class I; 26 Class II; and 27 Class III) were collected from a private orthodontic office. Following reliability studies, various parameters of the craniofacial complex, airway volume, and MCA were measured utilizing Dolphin 3D software. Comparisons among the three dental and the skeletal malocclusion classes were performed using one-way ANOVA and Fishers Protected Least Significant. Associations of the airway volumes and the MCA with other parameters were determined using correlation coefficients, accepting p < 0.05 as significant for all tests. Results: Maxillary right sinus volume was the only airway segment showing significant difference among different dental classes. Maxillary sinus volume also correlated moderately with anterior facial height and mandibular length. No significant differences were found between the MCA and different dentoskeletal classifications. Conclusions: The only significant difference in airway parameters among the dentoskeletal classes was that the dental Class II subjects had greater right sinus volume than the other classes. Shorter anterior facial height or mandibular length could be indicators for decreased airway volume in children. Funding: IUSD Graduate Research Committee, IUPUI Three-Dimensional Imaging of the Craniofacial Complex Center, Jarabak Endowed Professorshi

Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2′:6′,2″-terpyridine ligands: From in vitro to in vivo biological properties

This work was supported by the Applied Molecular Biosciences Unit - UCIBIO which is financed by national funds from FCT (UIDP/04378/2020, UIDB/04378/2020 and fellowships SFRH/BPD/124612/2016 (C. Roma-Rodrigues), and PTDC/CVT-EPI/6685/2014 (L R. Raposo)).Cancer is the second leading cause of death worldwide. Cisplatin has challenged cancer treatment; however, resistance and side effects hamper its use. New agents displaying improved activity and more reduced side effects relative to cisplatin are needed. In this work we present the synthesis, characterization and biological activities of three complexes with quinoline-substituted 2,2′:6′,2″-terpyridine ligand: [Pt(4′-(2-quin)-terpy)Cl](SO3CF3) (1), [Au(4′-(2-quin)-terpy)Cl](PF6)2·CH3CN (2) and [Cu(4′-(2-quin)-terpy)Cl](PF6) (3). The three complexes displayed a high antiproliferative activity in ovarian carcinoma cell line (A2780) and even more noticeable in a colorectal carcinoma cell line (HCT116) following the order 3 > 2 > 1. The complexes IC50 are at least 20 × lower than the IC50 displayed by cisplatin (15.4 μM) in HCT116 cell line while displaying at the same time, much reduced cytotoxicity in a normal dermal fibroblast culture. These cytotoxic activities seem to be correlated with the inclination angles of 2-quin unit to the central pyridine. Interestingly, all complexes can interact with calf-thymus DNA (CT-DNA) in vitro via different mechanisms, although intercalation seems to be the preferred mechanism at least for 2 and 3 at higher concentrations of DNA. Moreover, circular dichroism (CD) data seems to indicate that complex 3, more planar, induces a high destabilization of the DNA double helix (shift from B-form to Z-form). Higher the deviation from planar, the lower the cytotoxicity displayed by the complexes. Cellular uptake may be also responsible for the different cytotoxicity exhibited by complexes with 3 > 2 >1. Complex 2 seems to enter cells more passively while complex 1 and 3 might enter cells via energy-dependent and -independent mechanisms. Complexes 1–3 were shown to induce ROS are associated with the increased apoptosis and autophagy. Moreover, all complexes dissipate the mitochondrial membrane potential leading to an increased BAX/BCL-2 ratio that triggered apoptosis. Complexes 2 and 3 were also shown to exhibit an anti-angiogenic effect by significantly reduce the number of newly formed blood vessel in a CAM model with no toxicity in this in vivo model. Our results seem to suggest that the increased cytotoxicity of complex 3 in HCT116 cells and its potential interest for further translation to pre-clinical mice xenografts might be associated with: 1) higher % of internalization of HCT116 cells via energy-dependent and -independent mechanisms; 2) ability to intercalate DNA and due to its planarity induced higher destabilization of DNA; 3) induce intracellular ROS that trigger apoptosis and autophagy; 4) low toxicity in an in vivo model of CAM; 5) potential anti-angiogenic effect.publishersversionpublishe

Three and four current reversals versus temperature in correlation ratchets with a simple sawtooh potential

Transport of Brownian particles on a simple sawtooth potential subjected to both unbiased thermal and nonequilibrium symmetric three-level Markovian noise is considered. The new effects of three and four current reversals as a function of temperature are established in such correlation ratchets. The parameter space coordinates of the fixed points associated with these current reversals and the necessary and sufficient conditions for the existence of the novel current reversals are found.Comment: 4 pages, 5 figures; some changes introduced; accepted for publication in Physical Review