Design and development of a theory-informed peer-led falls prevention education programme to translate evidence into practice: A systematic approach

Peer-led education has been shown to be an effective approach for raising community-dwelling older adults’ beliefs, knowledge and intention to engage in falls prevention strategies in a recent intervention trial. This article outlines the design and development of the intervention, which was a peer-led falls prevention education programme designed to promote older adult’s motivation to change their behaviour in the area of falls prevention. The elements of the programme that contributed to its efficacy are also described. The programme was designed using a four-step approach and was based on the constructs of a theoretical framework (the COM-B model). Feedback from older adults was also incorporated into the programme development. Programme components developed were a workshop to train older adult peer educators to deliver falls prevention education, a one-hour peer-led falls prevention presentation, and supporting resources to aid programme delivery. A questionnaire measuring older adults’ responses to the presentation was concurrently developed and pilot-tested prior to implementation of the education programme. Finally, resources to monitor and evaluate fidelity at five points in the programme were developed. It was found that seeking older adult consumer involvement, and adopting a theoretical framework-driven approach contributes to effective design and delivery of falls prevention education programmes. This ensured that the programme was acceptable to older adults, feasible to deliver and allowed robust measurement of the effect of the education programme on important behavioural change components

Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries.

Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown. The objective of this study was to identify VICs in human arteries and to ascertain their role. VICs were identified in the wall of human gastro-omental arteries using transmission electron microscopy. Isolated VICs showed ability to form new and elongate existing filopodia and actively change body shape. Most importantly sprouting VICs were also observed in cell dispersal. RT-PCR performed on separately collected contractile vascular smooth muscle cells (VSMCs) and VICs showed that both cell types expressed the gene for smooth muscle myosin heavy chain (SM-MHC). Immunofluorescent labelling showed that both VSMCs and VICs had similar fluorescence for SM-MHC and αSM-actin, VICs, however, had significantly lower fluorescence for smoothelin, myosin light chain kinase, h-calponin and SM22α. It was also found that VICs do not have cytoskeleton as rigid as in contractile VSMCs. VICs express number of VSMC-specific proteins and display features of phenotypically modulated VSMCs with increased migratory abilities. VICs, therefore represent resident phenotypically modulated VSMCs that are present in human arteries under normal physiological conditions

Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury

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Discrepant FA reduction between the frontal and parietal lobes of post irradiation medulloblastoma survivors: preliminary findings of regional susceptibility?

In this study of 16 medulloblastoma survivors and corresponding age-matched control subjects, we tested the hypothesis that fractional anisotropy (FA) in the frontal lobe is more severely reduced than the parietal lobe after whole brain irradiation. Quantitative measurement of regional mean FA was performed using automatically generated masks. We found significant FA reduction in the frontal lobe, but not parietal lobe, in the medulloblastoma survivors compared to controls. Although more severe FA reduction in the frontal lobe was found, this difference did not achieve statistical significance. However, a trend of regional susceptibility of the frontal lobe to radiation was suggested.published_or_final_versio

Improving health professional\u27s knowledge of hepatitis B using cartoon based learning tools: a retrospective analysis of pre and post tests

Background: Hepatitis B serology is complex and a lack of knowledge in interpretation contributes to the inadequate levels of screening and referral for highly effective hepatitis antiviral treatments. This knowledge gap needs to be addressed so that current and future healthcare professionals are more confident in the detection and assessment of hepatitis B to improve the uptake of treatment and reduce long-term complications from the disease. Cartoons have been used effectively as a teaching tool in other settings and were considered as a potentially useful teaching aid in explaining hepatitis B serology. This study examines the impact of cartoons in improving healthcare professionals’ knowledge. Methods: A cartoon based learning tool designed to simplify the complexities of hepatitis B serology was developed as part of an online learning program for medical practitioners, nurses and students in these professions. A retrospective analysis was carried out of pre and post online test results. Results: An average improvement of 96% of correct answers to case study questions in hepatitis B serology was found across all ten questions following the use of an online cartoon based learning tool. Conclusion: The data indicates a significant improvement of participants’ knowledge of hepatitis B serology from pre-test to post-test immediately following an online cartoon based learning tool. However, further research is required to measure its long term impact

Diffusion tensor MR imaging in the evaluation of Wallerian degeneration in pediatric strokes: work-in-progress

Poster Session - Pediatric Brain MR Imaging: no. 2090We use DTI to detect and quantify Wallerian degeneration (WD) in pediatric MCA strokes. Fractional anisotropy (FA) and mean diffusivity (MD)of the infarction, ipsilateral internal capsule (PLIC) and cerebral peduncle (CP) were measured in nine children and compared to the matched contralateral side. WD was characterized by statistically significant differences in FA, but not MD, of the ipsilateral PLIC and CP compared to normal side. FA was reduced in all children, whilst corresponding hyperintense signals on T2W were seen in five children. DTI is more sensitive than conventional MRI and can be used to detect and quantify WD.published_or_final_versio

Factors associated with loss of white matter anisotropy in post-treatment medulloblastoma survivors

We evaluate effects of age at cranial irradiation, time interval since irradiation and irradiation dose on white matter anisotropy in childhood medulloblastoma survivors by computing white matter fractional anisotropy (WM FA) using SPM post-processing functions. Mean percentage change in WM FA of patients compared to controls was -4.4% (sd=7.6%). Using Spearmanís correlation, there were significant associations between percentage reduction of WM FA and age at cranial irradiation (r=0.673, p=0.002) and irradiation dose (r=-0.723, p=<0.001), but not with time interval since irradiation. Multivariate regression analysis confirmed that both factors correlated significantly with percentage reduction of WM FA (adjusted r2=0.516, p=0.001).published_or_final_versio

Design and characterisation of metallic glassy alloys of high neutron shielding capability

This paper reports the design, making and characterisation of a series of Fe-based bulk metallic glass alloys with the aim of achieving the combined properties of high neutron absorption capability and sufficient glass forming ability. Synchrotron X-ray diffraction and pair distribution function methods were used to characterise the crystalline or amorphous states of the samples. Neutron transmission and macroscopic attenuation coefficients of the designed alloys were measured using energy resolved neutron imaging method and the very recently developed microchannel plate detector. The study found that the newly designed alloy (Fe48Cr15Mo14C15B6Gd2 with a glass forming ability of Ø5.8 mm) has the highest neutron absorption capability among all Fe-based bulk metallic glasses so far reported. It is a promising material for neutron shielding applications

Cartoons for e-health informatics

Not only is Hepatitis B serology often misunderstood because of its complex serological implications, but advances in medical science have revolutionised screening and treatment of hepatitis B. To maximise such evolution however, this new information must be relayed effectively and efficiently to current and future medical professionals. Cartoons have been well regarded as a teaching tool in a variety of different settings as is the use of web based technology. Therefore the delivery of a cartoon based learning tool, accessed via on-line learning modules was considered a novel and potentially effective way of disseminating new knowledge. To increase health professionals’ understanding of hepatitis B serology and skill in interpreting the tests that indicate the appropriate treatment, a cartoon series was developed. The cartoons are located on an online educational website and include characters that represent the different antibodies and antigens associated with hepatitis B. The cartoon characters are involved in a series of adventures that represent the various phases of hepatitis B infection, and the paper describes their development. Subsequent research demonstrated that exposure to the online cartoon based learning tool indicates that they are a fun and useful way to increase knowledge

E-Queue Mobile Application: Empirical Study in Malaysia UTAR University

Waiting in line is a common experience in daily life, whether for a table at a popular restaurant or for the service at a bank. This experience is not always pleasant for most of people because they always have to wait for a long time to be serviced. The ability to interact with waiting customers is highly desirable because it allows businesses the opportunity to optimize their existing services and offer new services to waiting customers. However, interacting with individuals waiting in a queue has been inefficient and costly because employees must either talk with each waiting customer on an ongoing basis or the business must provide high tech devices that interact with each waiting customer. Agile methodology which will be used to develop this application, it incorporates the SDLC phases starting from the Planning phase up to the Maintenance phase. End of the research, we found that majority of respondents are prefer to use the proposed system compared with current method