100 research outputs found
In situ theranostic platform uniting highly localized magnetic fluid hyperthermia, magnetic particle imaging, and thermometry in 3D
In all of medical profession a broad field of research is dedicated to seek
less invasive and low-risk forms of therapy with the ultimate goal of
non-invasive therapy, particularly in neoplasmic diseases. Theranostic
platforms, combining diagnostic and therapeutic approaches within one system,
have thus garnered interest to augment invasive surgical, chemical, and
ionizing interventions. Magnetic particle imaging (MPI) offers, with its
versatile tracer material (superparamagnetic iron oxide nanoparticles, SPIOs),
a quite recent alternative to established radiation based diagnostic
modalities. In addition, MPI lends a bimodal theranostic frame allowing to
combine tomographic imaging with therapy techniques using the very same SPIOs.
In this work, we show for the first time the interleaved combination of
MPI-based imaging, therapy (highly localized magnetic fluid hyperthermia) and
therapy safety control (MPI-based thermometry) within one theranostic platform
in all three spatial dimensions
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