A new model to support the personalised management of a quality e-commerce service

The paper presents an aiding model to support the management of a high quality e-commerce service. The approach focuses on the service quality aspects related to customer relationship management (CRM). Knowing the individual characteristics of a customer, it is possible to supply a personalised and high quality service. A segmentation model, based on the "relationship evolution" between users and Web site, is developed. The method permits the provision of a specific service management for each user segment. Finally, some preliminary experimental results for a sport-clothing industry application are described

A New Forecasting Model for the Diffusion of ISO 9000 Standard Certifications in European Countries

ISO 9000 standards for quality system management are involving a higher and higher number of enterprises and organizations. This paper presents a detailed analysis of certification diffusion in Italy and in some European countries with similar economic structures. Benchmarking and evolution forecasts are based on the "logistic model", traditionally used for studying biological growth phenomena. The presentation is supported by many empirical data, which show that, in many countries, the phenomenon is going to be close to saturation. Finally, some considerations about new developments, after the present "certification era", are proposed

Strategic Debt in Vertical Relationships

We study a vertical relationship between two firms, and we show that the extent of the downstream firm's borrowing affects the contract offered by the upstream firm. We establish a negative relationship between the level of debt and the downstream firm's probability of bankrupt. We also show that, unless the interest rate is very high, there exists a conflict of interest between the upstream and the downstream firm: the latter wants to take on more debt than the former would like it to.We interpret this finding as an explanation of the constraint imposed by franchisors on the debt level of their franchisees.Contract Theory, Capital Structure, Franchise

Fottiti amico

Perché traduzione dell'immagine? Perché lo spettatore straniero è in effetti costretto ad operare una traduzione mentale delle immagini che scorrono sullo schermo. Lo spettatore italiano di un film americano non doppiato non vede esattamente un film in versione originale: è costretto, in realtà, a tradurre mentalmente le immagini che percepisce. Noi qui ci occupiamo in particolare del processo traduttivo della colonna sonora. Parlo volutamente di traduzione della colonna sonora perché mi piacerebbe, come professionista del doppiaggio cinetelevisivo, offrire uno spunto di riflessione ai professionisti della ricerca

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins

The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance mechanism for a plethora of cancer chemotherapeutics including for example taxenes, anthracyclines, Vinca alkaloids, and epipodopyllotoxins, demonstrated by a large array of published papers, both in tumor cell lines and in a variety of tumors, including various solid tumors and hematological malignancies. Upon repeated or even single dose treatment of cultured tumor cells or tumors in vivo with anti-tumor agents such as paclitaxel and doxorubicin, increased ABCB1 copy number has been demonstrated, resulting from chromosomal amplification events at 7q11.2-21 locus, leading to marked P-glycoprotein overexpression, and multidrug resistance (MDR). Clearly however, additional mechanisms such as single nucleotide polymorphisms (SNPs) and epigenetic modifications have shown a role in the overexpression of ABCB1 and of other MDR efflux pumps. However, notwithstanding the design of 4 generations of ABCB1 inhibitors and the wealth of information on the biochemistry and substrate specificity of ABC transporters, translation of this vast knowledge from the bench to the bedside has proven to be unexpectedly difficult. Many studies show that upon repeated treatment schedules of cell cultures or tumors with taxenes and anthracyclines as well as other chemotherapeutic drugs, amplification, and/or overexpression of a series of genes genomically surrounding the ABCB1 locus, is observed. Consequently, altered levels of other proteins may contribute to the establishment of the MDR phenotype, and lead to poor clinical outcome. Thus, the genes contained in this ABCB1 amplicon including ABCB4, SRI, DBF4, TMEM243, and RUNDC3B are overexpressed in many cancers, and especially in MDR tumors, while TP53TG1 and DMTF1 are bona fide tumor suppressors. This review describes the role of these genes in cancer and especially in the acquisition of MDR, elucidates possible connections in transcriptional regulation (co-amplification/repression) of genes belonging to the same ABCB1 amplicon region, and delineates their novel emerging contributions to tumor biology and possible strategies to overcome cancer MDR

Density of States and Critical Behavior of the Coulomb Glass

We present zero-temperature simulations for the single-particle density of states of the Coulomb glass. Our results in three dimensions are consistent with the Efros and Shklovskii prediction for the density of states. Finite-temperature Monte Carlo simulations show no sign of a thermodynamic glass transition down to low temperatures, in disagreement with mean-field theory. Furthermore, the random-displacement formulation of the model undergoes a transition into a distorted Wigner crystal for a surprisingly broad range of the disorder strength.Comment: 4 pages, 2 figures, 1 tabl

Introducing new molecular technologies into routine clinical cancer care: is there an impact on the treatment of breast cancer?

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Engineering exotic phases for topologically-protected quantum computation by emulating quantum dimer models

We use a nonperturbative extended contractor renormalization (ENCORE) method for engineering quantum devices for the implementation of topologically protected quantum bits described by an effective quantum dimer model on the triangular lattice. By tuning the couplings of the device, topological protection might be achieved if the ratio between effective two-dimer interactions and flip amplitudes lies in the liquid phase of the phase diagram of the quantum dimer model. For a proposal based on a quantum Josephson junction array [L. B. Ioffe {\it et al.}, Nature (London) {\bf 415}, 503 (2002)] our results show that optimal operational temperatures below 1 mK can only be obtained if extra interactions and dimer flips, which are not present in the standard quantum dimer model and involve three or four dimers, are included. It is unclear if these extra terms in the quantum dimer Hamiltonian destroy the liquid phase needed for quantum computation. Minimizing the effects of multi-dimer terms would require energy scales in the nano-Kelvin regime. An alternative implementation based on cold atomic or molecular gases loaded into optical lattices is also discussed, and it is shown that the small energy scales involved--implying long operational times--make such a device impractical. Given the many orders of magnitude between bare couplings in devices, and the topological gap, the realization of topological phases in quantum devices requires careful engineering and large bare interaction scales.Comment: 12 pages, 10 figure

Detection and isolation of circulating tumor cells with single-cell resolution: A successful lab-on-a-chip device

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.This paper presents the unique features of DEPArray™ an automated system enabling image-based cell sorting with single-cell resolution and describes its potential application in the field of oncology