Collective Dynamics and Strong Pinning near the Onset of Charge Order in La1.48_{1.48}Nd0.4_{0.4}Sr0.12_{0.12}CuO4_{4}

The dynamics of charge-ordered states is one of the key issues in underdoped cuprate high-temperature superconductors, but static short-range charge-order (CO) domains have been detected in almost all cuprates. We probe the dynamics across the CO (and structural) transition in La$_{1.48}$Nd$_{0.4}$Sr$_{0.12}$CuO$_{4}$ by measuring nonequilibrium charge transport, or resistance $R$ as the system responds to a change in temperature and to an applied magnetic field. We find evidence for metastable states, collective behavior, and criticality. The collective dynamics in the critical regime indicates strong pinning by disorder. Surprisingly, nonequilibrium effects, such as avalanches in $R$, are revealed only when the critical region is approached from the charge-ordered phase. Our results on La$_{1.48}$Nd$_{0.4}$Sr$_{0.12}$CuO$_{4}$ provide the long-sought evidence for the fluctuating order across the CO transition, and also set important constraints on theories of dynamic stripes.Comment: final version: 5 pages, 3 figures; includes Supplemental Material (3 pages, 7 figures

Current-voltage characteristics and vortex dynamics in highly underdoped La2−x_{2-x}Srx_{x}CuO4_{4}

The temperature dependence of the nonlinear current-voltage ($I$-$V$) characteristics in highly underdoped La$_{2-x}$Sr$_{x}$CuO$_{4}$ ($x=0.07$ and 0.08) thick films has been studied in both zero and perpendicular magnetic fields $H$. Power-law behavior of $V(I)$ is found for both $H=0$ and $H \neq 0$. The critical current $I_{c}$ was extracted, and its temperature and magnetic field dependences were studied in detail. The Berezinskii-Kosterlitz-Thouless physics dominates the nonlinear $I$-$V$ near the superconducting transition at $H=0$, and it continues to contribute up to a characteristic temperature $T_x(H)$. Nonlinear $I$-$V$ persists up to an even higher temperature $T_{h}(H)$ due to the depinning of vortices.Comment: 4 pages, 4 figures; Superstripes 2015 conferenc

Effect of Local Magnetic Moments on the Metallic Behavior in Two Dimensions

The temperature dependence of conductivity $\sigma (T)$ in the metallic phase of a two-dimensional electron system in silicon has been studied for different concentrations of local magnetic moments. The local moments have been induced by disorder, and their number was varied using substrate bias. The data suggest that in the limit of $T\to 0$ the metallic behavior, as characterized by $d\sigma/dT < 0$, is suppressed by an arbitrarily small amount of scattering by local magnetic moments.Comment: 4 pages, revtex, plus four encapsulated postscript figure

Mesoscopic Behavior Near a Two-Dimensional Metal-Insulator Transition

We study conductance fluctuations in a two-dimensional electron gas as a function of chemical potential (or gate voltage) from the strongly insulating to the metallic regime. Power spectra of the fluctuations decay with two distinct exponents (1/v_l and 1/v_h). For conductivity $\sigma\sim 0.1 e^{2}/h$, we find a third exponent (1/v_i) in the shortest samples, and non-monotonic dependence of v_i and v_l on \sigma. We study the dependence of v_i, v_l, v_h, and the variances of corresponding fluctuations on \sigma, sample size, and temperature. The anomalies near $\sigma\simeq 0.1 e^{2}/h$ indicate that the dielectric response and screening length are critically behaved, i.e. that Coulomb correlations dominate the physics.Comment: Revised according to referee remark

Tuning from failed superconductor to failed insulator with magnetic field

Do charge modulations compete with electron pairing in high-temperature copper-oxide superconductors? We investigated this question by suppressing superconductivity in a stripe-ordered cuprate compound at low temperature with high magnetic fields. With increasing field, loss of three-dimensional superconducting order is followed by reentrant two-dimensional superconductivity and then an ultra-quantum metal phase. Circumstantial evidence suggests that the latter state is bosonic and associated with the charge stripes. These results provide experimental support to the theoretical perspective that local segregation of doped holes and antiferromagnetic spin correlations underlies the electron-pairing mechanism in cuprates.Comment: 20 pp, 4 figs.; accepted version; for open-access published version, click on DOI belo

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations can increase channel activity by multiple molecular mechanisms. In this study, we determined the mechanism by which KATP function is altered by several substitutions in distinct structural domains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/R1154W in TMD2. We engineered substitutions at their equivalent positions in rat SUR2A (D207E, Y981S, G985E, M1056I, and R1150Q/R1150W) and investigated functional consequences using macroscopic rubidium (86Rb-) efflux assays and patchclamp electrophysiology. Our results indicate that D207E increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation. We also tested the responses of these channel variants to inhibition by the sulfonylurea drug glibenclamide, a potential pharmacotherapy for CS. None of the D207E, Y981S, G985E, or M1056I substitutions had a significant effect on glibenclamide sensitivity. However, Gln and Trp substitution at Arg-1150 significantly decreased glibenclamide potency. In summary, these results provide additional confirmation that mutations in CS-Associated SUR2 mutations result in KATP gain-of-function. They help link CS genotypes to phenotypes and shed light on the underlying molecular mechanisms, including consequences for inhibitory drug sensitivity, insights that may inform the development of therapeutic approaches to manage CS