Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina

In albino mammals, lack of pigment in the retinal pigment epithelium is associated with retinal defects, including poor visual acuity from a photoreceptor deficit in the central retina and poor depth perception from a decrease in ipsilaterally projecting retinal fibers. Possible contributors to these abnormalities are reported delays in neuronogenesis (Ilia and Jeffery, 1996) and retinal maturation (Webster and Rowe, 1991). To further determine possible perturbations in neuronogenesis and/or differentiation, we used cell-specific markers and refined birth dating methods to examine these events during retinal ganglion cell (RGC) genesis in albino and pigmented mice from embryonic day 11 (E11) to E18. Our data indicate that relative to pigmented mice, more ganglion cells are born in the early stages of neuronogenesis in the albino retina, although the initiation of RGC genesis in the albino is unchanged. The cellular organization of the albino retina is perturbed as early as E12. In addition, cell cycle kinetics and output along the nasotemporal axis differ in retinas of albino and pigmented mice, both absolutely, with the temporal aspect of the retina expanded in albino, and relative to the position of the optic nerve head. Finally, blocking melanin synthesis in pigmented eyecups in culture leads to an increase in RGC differentiation, consistent with a role for melanin formation in regulating RGC neuronogenesis. These results point to spatiotemporal defects in neuronal production in the albino retina, which could perturb expression of genes that specify cell fate, number, and/or projection phenotyp

Regge-cascade hadronization

We argue that the evolution of coloured partons into colour-singlet hadrons has approximate factorization into an extended parton-shower phase and a colour-singlet resonance--pole phase. The amplitude for the conversion of colour connected partons into hadrons necessarily resembles Regge-pole amplitudes since qq-bar resonance amplitudes and Regge-pole amplitudes are related by duality. A `Regge-cascade' factorization property of the N-point Veneziano amplitude provides further justification of this protocol. This latter factorization property, in turn, allows the construction of general multi-hadron amplitudes in amplitude-squared factorized form from (1->2) link amplitudes. We suggest an algorithm with cascade-decay configuration, ordered in the transverse momentum, suitable for Monte-Carlo simulation. We make a simple implementation of this procedure in Herwig++, obtaining some improvement to the description of the event-shape distributions at LEP.Comment: 10 pages, 9 figure

Vector Meson Photoproduction with an Effective Lagrangian in the Quark Model

A quark model approach to the photoproduction of vector mesons off nucleons is proposed. Its starting point is an effective Lagrangian of the interaction between the vector meson and the quarks inside the baryon, which generates the non-diffractive s- and u- channel resonance contributions. Additional t-channel $\pi^0$ and $\sigma$ exchanges are included for the $\omega$ and $\rho^0$ production respectively to account for the large diffractive behavior in the small $t$ region as suggested by Friman and Soyeur. The numerical results are presented for the $\omega$ and $\rho$ productions in four isospin channels with the same set of parameters, and they are in good agreement with the available data not only in $\omega$ and $\rho^0$ productions but also in the charged $\rho$ productions where the additional t-channel $\sigma$ exchange does not contribute so that it provides an important test to this approach. The investigation is also extended to the $\phi$ photoproduction, and the initial results show that the non-diffractive behavior of the $\phi$ productions in the large $t$ region can be described by the s- and u- channel contributions with significantly smaller coupling constants, which is consistent with the findings in the similar studies in the QHD framework. The numerical investigation has also shown that polarization observables are essential for identifying so-called "missing resonances".Comment: 36 pages, 10 PS figures, extended version of nucl-th/9711061 and nucl-th/9803021, submitted to PR

The Kaon-Photoproduction Of Nucleons In The Quark Model

In this paper, we develop a general framework to study the meson-photoproductions of nucleons in the chiral quark model. The S and U channel resonance contributions are expressed in terms of the Chew-Goldberger-Low-Nambu (CGLN) amplitudes. The kaon-photoproduction processes, $\gamma p\to K^+ \Lambda$, $\gamma p\to K^+ \Sigma^0$, and $\gamma p\to K^0\Sigma^+$, are calculated. The initial results show that the quark model provides a much improved description of the reaction mechanism for the kaon-photoproductions of the nucleon with less parameters than the traditional phenomenological approaches.Comment: 25 pages, 9 postscript figures can be obtained from the author

An Unified Approach To Pseudo Scalar Meson Photoproductions Off Nucleons In The Quark Model

An unified approach to the pseudo scalar meson ($\pi, \eta$, and $K$) photoproduction off nucleons are presented. It begins with the low energy QCD Lagrangian, and the resonances in the s- and u- channels are treated in the framework of the quark model The duality hypothesis is imposed to limit the number of the t-channel exchanges. The CGLN amplitudes for each reaction are evaluated, which include both proton and neutron targets. The important role by the S-wave resonances in the second resonance region is discussed, it is particularly important for the $K, \eta$ and $\eta^\prime$ photoproductions.Comment: 31 pages in Latex fil

Local Duality Predictions for x ~ 1 Structure Functions

Recent data on the proton F_2 structure function in the resonance region suggest that local quark-hadron duality works remarkably well for each of the low-lying resonances, including the elastic, to rather low values of Q^2. We derive model-independent relations between structure functions at x ~ 1 and elastic electromagnetic form factors, and predict the x -> 1 behavior of nucleon polarization asymmetries and the neutron to proton structure function ratios from available data on nucleon electric and magnetic form factors.Comment: 10 pages, 2 figures, typos in Eq. (2) correcte

Soft two-meson-exchange nucleon-nucleon potentials. II. One-pair and two-pair diagrams

Two-meson-exchange nucleon-nucleon potentials are derived where either one or both nucleons contains a pair vertex. Physically, the meson-pair vertices are meant to describe in an effective way (part of) the effects of heavy-meson exchange and meson-nucleon resonances. {}From the point of view of ``duality,'' these two kinds of contribution are roughly equivalent. The various possibilities for meson pairs coupling to the nucleon are inspired by the chiral-invariant phenomenological Lagrangians that have appeared in the literature. The coupling constants are fixed using the linear $\sigma$ model. We show that the inclusion of these two-meson exchanges gives a significant improvement over a potential model including only the standard one-boson exchanges.Comment: 21 pages RevTeX, 7 postscript figures; revised version as to appear in Phys. Rev.

Flavour structure of low-energy hadron pair photoproduction

We consider the process $\gamma\gamma\to H_1\bar H_2$ where $H_1$ and $H_2$ are either mesons or baryons. The experimental findings for such quantities as the $p\bar p$ and $K_SK_S$ differential cross sections, in the energy range currently probed, are found often to be in disparity with the scaling behaviour expected from hard constituent scattering. We discuss the long-distance pole--resonance contribution in understanding the origin of these phenomena, as well as the amplitude relations governing the short-distance contribution which we model as a scaling contribution. When considering the latter, we argue that the difference found for the $K_SK_S$ and the $K^+K^-$ integrated cross sections can be attributed to the s-channel isovector component. This corresponds to the $\rho\omega\to a$ subprocess in the VMD (vector-meson-dominance) language. The ratio of the two cross sections is enhanced by the suppression of the $\phi$ component, and is hence constrained. We give similar constraints to a number of other hadron pair production channels. After writing down the scaling and pole--resonance contributions accordingly, the direct summation of the two contributions is found to reproduce some salient features of the $p\bar p$ and $K^+K^-$ data.Comment: 12 pages, 9 figures, revised version to be published in EPJ

Some Remarks on Theories with Large Compact Dimensions and TeV-Scale Quantum Gravity

We comment on some implications of theories with large compactification radii and TeV-scale quantum gravity. These include the behavior of high-energy gravitational scattering cross sections and consequences for ultra-high-energy cosmic rays and neutrino scattering, the question of how to generate naturally light neutrino masses, the issue of quark-lepton unification, the equivalence principle, and the cosmological constant.Comment: 28 pages, Late