THE VARIOUS SOURCES OF L-ASPARAGINASE

ARTICLE INFO ABSTRACT L-asparaginase (E.C. 3.5.1.1.), also known as L-asparagine amidohydrolase is the enzyme with anti-tumor activity and is well accepted as a chemotherapeutic agent against the acute lymphoblastic leukemia and lymphosarcoma. L-asparaginase is an enzyme that reduces the activity of L-asparaginase (an important nutrient for cancer cells) resulting in cancer/tumor cell starvation). L-asparaginase is a relatively wide spread enzyme found in many plant tissue, bacteria, plant and in the serum of certain rodents, but not of man. The present article comprises information on the enzyme L-asparaginase, which is used as a chemotherapeutic agent. The present review has discussed about the various sources, side effects, screening, properties and production of L-asparaginase