Output-only identification of rigid body motions of floating structures: a case study

In order to identify rigid body motions of floating offshore structures, output-only techniques are very useful for developing low-cost intermediate-scale experimental activities directly into the sea, instead of wave tanks. A crucial parameter, however, is the length of the response records used as input for the identification process, since short records may result in significant loss of accuracy, while long ones may be incompatible with the assumption of stationarity of the sea state. This work presents a sensitivity study conducted on a numerical model of a spar structure, identified by means of Enhanced Frequency Domain Decomposition method. An overview on the efficiency of the method is given for various lengths of response record, along with practical indications on the minimum values acceptable

On intermediate-scale open-sea experiments on floating offshore structures: Feasibility and application on a spar support for offshore wind turbines

Experimental investigation of floating structures represents the most direct way for achieving their dynamic identification and it is particularly valuable for relatively new concepts, such as floating supports for offshore wind turbines, in order to fully understand their dynamic behaviour. Traditional experimental campaigns on floating structures are carried out at small scale, in indoor laboratories, equipped with wave and wind generation facilities. This article presents the results of an open-sea experimental activity on a 1:30 scale model of the OC3-Hywind spar, in parked rotor conditions, carried out at the Natural Ocean Engineering Laboratory (NOEL) of Reggio Calabria (Italy). The aim of the experiment is two-fold. Firstly, it aims to assess the feasibility of low-cost, intermediate-scale, open-sea activities on offshore structures, which are proposed to substitute or complement the traditional indoor activities in ocean basins. Secondly, it provides useful experimental data on damping properties of spar support structures for offshore wind turbines, with respect to heave, roll and pitch degrees of freedom. It is proven that the proposed approach may overcome some limitations of traditional small-scale activities, namely high costs and small scale, and allows to enhance the fidelity of the experimental data currently available in literature for spar floating supports for offshore wind turbines

Phylobioactive hotspots in plant resources used to treat Chagas disease

Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extracts of botanical drugs used in Bolivia in the context of CD and botanical drugs from unrelated indications from the Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled in a multidimensional assay uncovering different antichagasic natural product classes. Intriguingly, the phylobioactive anthraquinone hotspot matched the antichagasic activity of Senna chloroclada, the taxon with the strongest ethnomedical consensus for treating CD among the Izoceño-Guaraní. Testing common 9,10-anthracenedione derivatives in T. cruzi cellular infection assays demarcates hydroxyanthraquinone as a potential antichagasic lead scaffold. Our study systematically uncovers in vitro antichagasic phylogenetic hotspots in the plant kingdom as a potential resource for drug discovery based on ethnopharmacological hypotheses

Alteration of Hypothalamic–Pituitary–Thyroid Axis Function in Non-Small-Cell Lung Cancer Patients

The aim of this study was to evaluate the hypothalamic–pituitary–thyroid (HPT) axis function in patients suffering from lung cancer. Thyrotropin-releasing hormone (TRH), thyroid-stimulating hormone (TSH), free thyroxine (FT4), interleukin (IL)-2, and melatonin serum levels were measured in blood samples collected every 4 hours for 24 hours from 11 healthy participants (H; ages 35-53 years) and 9 patients suffering from non-small-cell lung cancer (C; ages 43-63 years). Relationships between hormone levels overall and over time of day were evaluated within and among groups. A prominent circadian rhythm with peaks near midnight was present for TSH and melatonin serum levels in both H and C, indicating similar synchronization of the main body clock to the 24-hour environmental light–dark cycle. As regards 24-hour means in H and C, TSH was lower in C, whereas TRH, FT4, and IL-2 were higher in C, with no difference in melatonin levels. Simple linear regression, FT4 versus TRH, showed a positive correlation in H..

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

Cancer and viral infections continue to threaten humankind causing death worldwide. Hence, the discovery of new anticancer and antiviral agents still represents a major scientific goal. Heterocycles designed to mimic the chemical structure of natural pyrimidines and purines have been designed over the years, exerting their activity acting as false substrates on several different targets. We reported a series of bis-benzotriazole-dicarboxamide derivatives which inhibit viral helicase of poliovirus, and hence we planned structure modifications to obtain different series of new dicarboxamides. Here, the synthesis and characterization of 56 new compounds: 31 bis-benzotriazole dicarboxamides and 25 mono-substituted acidic derivatives are reported. The synthesized compounds were tested for their antiviral and antitumor activity. Mostly, compounds 4a, 4c and 4d showed antiviral activity against tested Picornaviruses, Coxsackievirus B5 and Poliovirus-1. Likewise, four derivatives (3b, 3d, 4d, 9b) showed notable antiproliferative activity inhibiting cell growth in two distinct antitumor screenings. Compound 3b was selected as the antitumor lead compound for the wide range of activity and the potency proved. The lead compound was proved to induce apoptosis in SK-MES1 tumor cells, in a dose-dependent manner

Is there more to Wnt signalling in breast cancer than stabilisation of β-catenin?

Increased Wnt signalling has been implicated in the aetiology of many different human cancers, including breast cancers. In most cases, Wnt signalling is thought to drive tumourigenesis through the stabilisation of cytosolic β-catenin and the subsequent changes in the expression of T-cell factor (TCF)-dependent genes. However, this is not necessarily the only mechanism, as Wnt proteins can signal through a number of different intracellular signalling pathways. The ongoing work from Nancy Hynes' laboratory continues to highlight this latter possibility

Analysis of the coupled dynamics of an offshore floating multi-purpose platform : part A - rigid body analysis

A multi-purpose platform (MPP) is an offshore system designed to serve the purposes of more than one offshore industry. Indeed, over the past decades, a number of industries have expanded, or are expanding, from onshore to offshore locations (renewables, aquaculture, tourism, mineral extractions, etc.), and the research on these type of platform is increasing. In the present work, a MPP able to accommodate wind turbines, wave energy converters, and aquaculture systems are considered. This work presents the first part (Part A) of the analyses of the dynamics of the floating support structure for this MPP, focusing on the rigid body dynamic response, while its complementary hydroelastic analysis is presented in Part B (OMAE2019-96282). The aim here is to assess the dynamic response of the platform with respect to the preliminary requirements imposed by the wind turbine, the aquaculture system, and the other ancillary systems. After describing the platform analyzed, and explaining the aero-hydro coupled model of dynamics approach adopted, two independent analyses are conducted, one using the SESAM package by DNV-GL, and another using ANSYS AQWA, in order to verify the results, in absence of experimental data. Considering a severe, but still operational, load case, the preliminary results seem to demonstrate that the chosen platform can satisfy the dynamics constraints imposed by the payload systems

Progress on the development of a holistic coupled model of dynamics for offshore wind farms : phase II - study on a data-driven based reduced-order model for a single wind turbine

At present, over 1500 offshore wind turbines (OWTs) are operating in the UK with a capacity of 5.4GW. Until now, the research has mainly focused on how to minimise the CAPEX, but Operation and Maintenance (O&M) can represent up to 39% of the lifetime costs of an offshore wind farm, mainly due to the assets’ high cost and the harsh environment in which they operate. Focusing on O&M, the HOME Offshore research project (www.homeoffshore.org) aims to derive an advanced interpretation of the fault mechanisms through holistic multiphysics modelling of the wind farm. With the present work, an advanced model of dynamics for a single wind turbine is developed, able to identify the couplings between aero-hydro-servo-elastic (AHSE) dynamics and drive train dynamics. The wind turbine mechanical components, modelled using an AHSE dynamic model, are coupled with a detailed representation of a variable-speed direct-drive 5MW permanent magnet synchronous generator (PMSG) and its fully rated voltage source converters (VSCs). Using the developed model for the wind turbine, several case studies are carried out for above and below rated operating conditions. Firstly, the response time histories of wind turbine degrees of freedom (DOFs) are modelled using a full-order coupled analysis. Subsequently, regression analysis is applied in order to correlate DOFs and generated rotor torque (target degree of freedom for the failure mode in analysis), quantifying the level of inherent coupling effects. Finally, the reduced-order multiphysics models for a single offshore wind turbine are derived based on the strength of the correlation coefficients. The accuracy of the proposed reduced-order models is discussed, comparing it against the full-order coupled model in terms of statistical data and spectrum. In terms of statistical results, all the reducedorder models have a good agreement with the full-order results. In terms of spectrum, all the reduced-order models have a good agreement with the full-order results if the frequencies of interest are below 0.75Hz

Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 $< p_{\rm{T}, assoc} < p_{\rm{T}, trig} <$ 5.0 GeV/$c$ is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range $|\eta|<0.9$. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161

Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multi-particle azimuthal correlations (cumulants) for charged particles in p-Pb and Pb-Pb collisions are presented. They help address the question of whether there is evidence for global, flow-like, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a $|\Delta \eta|$ gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high-multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of $v_{2}\{4\}$ to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find $v_{2}\{4\} \simeq v_{2}\{6\}\neq 0$ which is indicative of a Bessel-Gaussian function for the $v_{2}$ distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a $|\Delta\eta| > 1.4$ gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87