58 research outputs found
Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification.
Main Body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. The premises for cell type and origin selection or even absence of cells is being explored. Choice of several raw materials and scaffold fabrication methods are evaluated. Extensive studies have been developed for fully regeneration of the annulus fibrosus and nucleus pulposus, together or separately, with a long set of different rationales already reported. Recent works show promising biomaterials and processing methods applied to intervertebral disc substitutive or regenerative strategies. Facing the abundance of studies presented in the literature aiming intervertebral disc regeneration it is interesting to observe how cartilaginous endplates have been extensively neglected, being this a major source of nutrients and water supply for the whole disc.
Conclusion: Severalinnovative avenues for tackling intervertebral disc degeneration are being reported â from acellular to cellular approaches, but the cartilaginous endplates regeneration strategies remain unaddressed. Interestingly, patient-specific approaches show great promise in respecting patient anatomy and thus allow quicker translation to the clinics in the near future.The authors would like to acknowledge the support provided by the Portuguese
Foundation for Science and Technology (FCT) through the project EPIDisc
(UTAP-EXPL/BBBECT/0050/2014), funded in the Framework of the “International
Collaboratory for Emerging Technologies, CoLab”, UT Austin|Portugal Program.
The FCT distinctions attributed to J. Miguel Oliveira (IF/00423/2012 and IF/01285/
2015) and J. Silva-Correia (IF/00115/2015) under the Investigator FCT program are
also greatly acknowledged.info:eu-repo/semantics/publishedVersio
An Experimental Method for Measuring Force on the Spinal Facet Joint: Description and Application of the Method
Sektorale und gesamtwirtschaftliche Beurteilung des „Carbon-Leakage”-Problems für die Bundesrepublik Deutschland
Wrist Position Affects Loading of the Dorsal Scaphoid: Possible Effect on Extrinsic Scaphoid Blood Flow
Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 13: Injection therapies, low-back pain, and lumbar fusion
Auswirkungen und Perspektiven der Ă–kologischen Steuerreform in Deutschland: Eine modellgestĂĽtzte Analyse-super-*
A first systematic, model-based analysis of the environmental fiscal reform in Germany is undertaken with an econometric model and an empirical general equilibrium model. It indicates moderate but slightly positive effects on employment, energy consumption and CO_2 emissions. The influence on economic growth is very low; employment is growing slightly, while energy consumption and CO_2 emissions are decreasing. The sectoral development shows no universal pattern for a structural change to the disadvantage of energy intensive industries and to the benefit of labour intensive branches. The effects on personal income distribution, estimated with a micro simulation model, are moderate. The environmental fiscal reform could play a larger role in climate protection. Weaknesses of the previous concept should be removed gradually. Copyright Verein fĂĽr Socialpolitik und Blackwell Publishers Ltd, 2003
Prevention of thromboembolic complications with miniheparin-dihydroergotamine in patients undergoing lumbar disc operations
Cervical spinal stenosis: outcome after anterior corpectomy, allograft reconstruction, and instrumentation
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