Study of defect formation in Al 7050 alloys

The Al 7050 alloy is an Al-Zn-Mg-Cu-Zr alloy having good mechanical properties. This alloy has been developed in order to overcome stress corrosion cracking problems that characterise 7xxx Al alloys. Despite Al 7050 is widely used for aerospace applications, it can be subjected to crack initiation and propagation during the manufacturing process. In this work cracked Al 7050 components have been analysed in order to identify possible causes of crack formation such as coarse intermetallic phase presence, voids or wrong mechanical machining processes

Giant pseudo-Aneurysm of the Pancreatico-Duodenal Artery

We report a case of a giantpseudo-aneurysm of the pancreatico-duodenal arteryin a patient with no history of pancreatitis or trauma.Case ReportA 60-year-old woman was admitted to a peripheralhospital because of epigastric and periumbilical pain.She underwent an abdominal CT Scan (Fig. 1) whichshowed a large mass about 11.5£ 8c

Enhanced high-temperature mechanical behavior of an in situ TiAl matrix composite reinforced with alumina

A Ti-45Al-3Cr-2.5Nb alloy reinforced with in situ formed alumina has been produced by means of centrifugal casting by adding zirconium oxide in the crucible. The dispersion-strengthened alloy has been characterized to verify its microstructure and particle distribution. Mechanical tests carried out over the temperature range 850-950 degrees C highlighted that in situ formed alumina allows to increase the alloy yield stress by 21% at 850 degrees C and by 35% at 900 degrees C. Moreover, the in situ formed oxide particles produced an increase of the Young's modulus of about 10% at 850 degrees C and of about 8% at 900 degrees C. Considering that the tested alloy has a density that is about a half of nickel superalloys, obtaining high specific mechanical properties over the temperature range 850-950 degrees C can boost its application in the production of turbine blades

Mechanical behaviour of an Al2O3 dispersion strengthened γTiAl alloy produced by centrifugal casting

γ-TiAl has been a hot topic of research for more than a few decades now, since it is a potential candidate for high temperature structural applications. In this paper, dispersion strengthening of γ based TiAl alloy, produced by means of centrifugal casting, has been performed to increase its mechanical properties beyond those of standard TiAl alloys. After a careful selection of the alloy composition based on the desired properties, several samples were produced by means of investment casting. This work focused on the effect of Al2O3 nano-and micro-dispersoids on the mechanical properties of the considered TiAl alloy. Microstructural investigations were carried out to study both the alloy microstructure and the Al2O3 dispersion homogeneity. Samples of the produced alloy were subjected to four-point bending tests at different temperatures for evaluating the effect of dispersed particles on mechanical properties. The results of this study were promising and showed that Al2O3 dispersion determined an increase of the mechanical properties at high temperatures. The Young’s modulus was 30% higher than that of the reference alloy in the lower temperature range. Over the temperature range 800–950 °C the dispersion strengthening affected the yield stress by increasing its value of about 20% even at 800 °C. A detailed evaluation of fracture surfaces was carried out to investigate fracture mechanisms

Xenotransplantation of microencapsulated pancreatic islets contained in a vascular prosthesis: preliminary results

Porcine and human pancreatic islets were microencapsulated in an alginate-polylysine biomembrane and put in a chamber of a new vascular prosthesis composed of an inner tubing of Dacron mesh and an outer tubing of expanded polytetrafluorethylene material. The vascular prosthesis was anastomized between the iliac artery and the contralateral vein of diabetic dogs. The recipients did not receive any immunosuppressive therapy. Function of porcine and human islets was monitored by measuring serum glucose levels and human C-peptide concentrations. After transplantation, serum glucose levels were maintained at values lower than 200 mg/dl, and C-peptide concentrations were between 0.8 and 3.2 ng/ml. Injected insulin requirements decreased by 50%-60%. Four to 8 weeks after transplantation, histologic examination showed well-preserved and functioning islets in the majority of intact microcapsules. Fibrin and inflammatory cells were not observed in the chamber. These data suggest long-term survival and function of microencapsulated pancreatic islets in the vascular prosthesis. © 1991 Springer-Verlag

Constraints on the mantle sources of the Deccan traps from the petrology and geochemistry of the basalts of Gujarat state (Western India)

The late Cretaceous-early Tertiary flood basalts in the Gujarat area of the northwestern Deccan Traps (Kathiawar peninsula, Pavagadh hills and Rajpipla) exhibit a wide range of compositions, from picrite basalts to rhyolites; moreover, the basaltic rocks have clearly distinct TiO2 contents at any given degree of differentiation and strongly resemble the low-titanium and hightitanium basalts found in most of the Gondwana continental flood basalt (CFB) suites. Four magma groups are petrologically and geochemically distinguished: (1) A low-Ti group, characterized by rocks with varying SiO2 saturation, and with TiO2 <1.8 wt%, extremely low incompatible trace element abundances, low Zr/γ (av- 3.8), Ti/ V (av. 27), and a very slight large ion lithophile element (LJLE) enrichment over high field strength elements (HFSE). These rocks share some features with the Bushe Formation of the Western Ghats farther south, but have distinct geochemical characters, in particular the strong depletion in most incompatible trace elements. (2) A high-Ti group, characterized by a more K-rich character than the low-Ti rocks, and with a strong enrichment in incompatible elements, similar to average ocean island basalt (OIB), e.g. high TiO2 (>1.8 wt% in picrites), Nb (>19 p.p.m.) Zr/γ (av. 6.5) and Tt/V (av. 47). (3) An intermediate-Ti group, with TiO2 contents slightly lower than the high-Ti rocks at the same degree of evolution, and with correspondingly lower incompatible trace element contents and ratios, in particular K2O, Nb, Ba and Zr/Y (av. 5.2). (4) A potassium-rich group (KT), broadly similar in geochemical character to the high-Ti group but showing more extreme K, Rb and Ba enrichment (av. K20/Na20~l; Ba/Y~20). The most primitive low-Ti and high-Ti picrites, when corrected for low-pressure olivine fractionation, show distinct major (and trace) element geochemistry, in particular for CaO/AI2O3, CaO/TiO2 and Al2O3/TiO2, and moderate but significant variations in their SiO2 and Fe2Ost contents; these characteristics strongly suggest the involvement of different mantle sources, more depleted for the low-Ti picrites, and richer in cpxfor the high-Ti picrites, but with broadly the same pressures of equilibration (27-14 kbar). This, in turn, suggests a strong lateral heterogeneity in the Gujarat Trap mantle. Low-Ti picrites and related differentiates in Kathiawar are reported systematically for the first time here, and suggest the existence of HFSE-depleted mantle in the northwestern Deccan Traps, with extension at least to the Seychelles Islands and to the area of the Bushe Formation near Bombay in the pre-drift position, before the development of the Carlsberg Ridge. The absence of correlations between LILE/HFSE ratios and SiO2 argues against crustal contamination processes acting on the low-Ti picrites, possibly owing to their probably rapid uprise to the surface. Consequently, the mantle region of this rock group was probably re-enriched by small amounts of ULE-rich materials. The substantially higher, trace element enrichment of the least differentiated high-Ti picrites, relative to the basalts of the Ambe-noli and Mahableshwar Formations of the Western Ghats, testifies also to the presence of more incompatible element rich, OIB4ike mantle sources in northern and northwestern Gujarat. These sources were geochemicaily similar to the present-day Reunion mantle sources

Lipid Metabolism and Molecular Changes in Normal andAtherosclerotic Vessels

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Parathyroidectomy and survival in a cohort of Italian dialysis patients: results of a multicenter, observational, prospective study

Background: Severe secondary hyperparathyroidism (SHPT) is associated with mortality in end stage kidney disease (ESKD). Parathyroidectomy (PTX) becomes necessary when medical therapy fails, thus highlighting the interest to compare biochemical and clinical outcomes of patients receiving either medical treatment or surgery. Methods: We aimed to compare overall survival and biochemical control of hemodialysis patients with severe hyperparathyroidism, treated by surgery or medical therapy followed-up for 36 months. Inclusion criteria were age older than 18 years, renal failure requiring dialysis treatment (hemodialysis or peritoneal dialysis) and ability to sign the consent form. A control group of 418 patients treated in the same centers, who did not undergo parathyroidectomy was selected after matching for age, sex, and dialysis vintage. Results: From 82 Dialysis units in Italy, we prospectively collected data of 257 prevalent patients who underwent parathyroidectomy (age 58.2 ± 12.8 years; M/F: 44%/56%, dialysis vintage: 15.5 ± 8.4 years) and of 418 control patients who did not undergo parathyroidectomy (age 60.3 ± 14.4 years; M/F 44%/56%; dialysis vintage 11.2 ± 7.6 y). The survival rate was higher in the group that underwent parathyroidectomy (Kaplan–Meier log rank test = 0.002). Univariable analysis (HR 0.556, CI: 0.387–0.800, p = 0.002) and multivariable analysis (HR 0.671, CI:0.465–0.970, p = 0.034), identified parathyroidectomy as a protective factor of overall survival. The prevalence of patients at KDOQI targets for PTH was lower in patients who underwent parathyroidectomy compared to controls (PTX vs non-PTX: PTH < 150 pg/ml: 59% vs 21%, p = 0.001; PTH at target: 18% vs 37% p = 0.001; PTH > 300 pg/ml 23% vs 42% p = 0.001). The control group received more intensive medical treatment with higher prevalence of vitamin D (65% vs 41%, p = 0.0001), calcimimetics (34% vs 14%, p = 0.0001) and phosphate binders (77% vs 66%, p = 0.002). Conclusions: Our data suggest that parathyroidectomy is associated with survival rate at 36 months, independently of biochemical control. Lower exposure to high PTH levels could represent an advantage in the long term. Graphical abstract: [Figure not available: see fulltext.]