Néphit, vallás, mentalitás. Kéziratos és nyomtatott források, 16-19. század. Forrásfeltárás, -kiadás és kutatás = Folk belief, religion, mentality. Hand-written and printed sources, 16-19. centuries. Exploration, publication and study of sources

A kora újkor társadalmainak mentalitása, világképe, hiedelemrendszere: 1. Források feltárása, nyilvántartása és kiadása: Boszorkányperek dokumentumainak feltárása erdélyi, valamint felvidéki és magyarországi városokban: Összesen mintegy 400 új per birtokába jutottunk, kb 1500 oldal terjedelemben. A peranyag átírása, sajtó alá rendezése folyamatos: megjelent egy vármegyei és egy városi perdokumentumokat tartalmazó kötetünk. Magyarország területén használt varázskönyvek feltárása: elkészült egy kincskeresés szövegeit tartalmazó kötet. Magyarországi benedikciók és exorcizmusok kéziratos és nyomtatott forrásainak feltárása: egy kötet sajtó alatt. - A kora újkor református prédikációinak feltárása: megjelent egy babonaellenes és egy dohányzás-ellenes prédikációkat tartalmazó kötet. Kora újkori látomásszövegek feltárása és kiadása: megjelent egy 18. századi látomás-szövegeket tartalmazó kötet. 2. Kutatás folyt a következő témákban: A boszorkányüldözés historiográfiája, statisztikája, jogi háttere, társadalmi kontextusa, teológiai vonatkozásai, kezdetei és megszűnése; a mágia dekriminalizációja a magyar joggyakorlatban; a boszorkányság hiedelemrendszere; a varázskönyvek használata és használói; a prédikációk, mint az elit és népi kultúra kommunikációs csatornái; a prédikációk ördög-képzetei. E témákkal részt vettünk több fontos magyar és nemzetközi konferencián, szerveztünk is ilyenket. 12 kutató közel 100 tanulmánya illetve forráskiadványa készült el. | Mentality, world-view and belief-systems of the early modern communities: 1. Exploration, identifying and publishing sources: Exploring documents of witchcraft cases in cities in Transylvania, Slovakia and in Hungary. Altogether we have acquired the material of approximately 400 trials amounting to 1500 pages. We have continued transcribing the case material collected during the previous cycle and preparing it for print. We have published a volume containing trial material in the counties and one on that of the towns. Exploring handwritten and printed sources of benedictions and exorcisms in Hungary: a volume is in the press. Exploring Calvinist preachings of the early modern age: a volume of preachings against superstitions and another volume against smoking are published. Exploring and publishing visions-literature: we have published a book containing 18th century visions. 2. Research was carried out on the following subjects: The historiography and comprehensive statistics of witch-hunt; the legal background and social context of witch-hunt, the theological aspects, religious and clerical history of witch-hunts; the belief system of witchcraft; the use and the users of magic books; preachings as channels of communication between the elite and popular culture, concepts of the Satan in the Calvinist preachings. We have participated at several important Hungarian and international conferences, and we also organised two major and several minor conferences on these areas of research. In this area 12 researchers accomplished approximately 100 papers resp. books

Comparison of apples from organic and integrated farming

Prima’, ‘Gala’, ‘Remo’, ‘Topáz’, ‘Idared’, ‘Releika’, ‘Resi’, ‘Rubinola’, ‘Rajka’, ‘Rewena’ and ‘Florina’ apple cultivars, both from organic and integrated farming, from Pallag and Újfehértó, were compared. Average size, weight, soluble solids, titratable acidity, total polyphenols, free radical scavenging capacity expressed as Trolox equivalent (TEAC), copper and zinc were determined at harvest and after cool storage. Organic apples were more acidic, while integrated fruits had mostly higher copper and zinc content. Total polyphenols and TEAC values did not show a significant difference as a function of farming technology. A principal component analysis shows the separation of provenances as well as stored and fresh apples. Results are considered as preliminary

Coming out with the media: the ritualization of self-disclosure in the Dutch television program Uit de Kast

Using the media to disclose one’s sexual identity has become an increasingly salient practice in recent years. Yet little is known about the reasons for the emergence of this form of self-disclosure. Based on an analysis of the Dutch television programme Uit de Kast (‘Out of the Closet’), this article relates the rise of mediated coming out practices to the ritualizing power of the media: we argue that media plays a quintessential role in transforming the socially unscripted act of coming out into a patterned, culturally meaningful performance. Our analysis reveals that the ritual work of the programme is embedded in the ways 1) the generic format of the show structures the self-disclosures, 2) the authority of the media is deployed to channel the coming out process, and 3) the programme, while controlling diversity, reinforces dominant societal values and ideologies. The case not only highlights how unprecedented ritual forms come to flourish in the current era of ‘participatory’ media culture, but also demonstrates how ritualization supports and naturalizes the claim that media is an effective agent to create order in everyday, ordinary lives

Composition and sensory properties of sour cherry cultivars

Fruits of different sour cherry varieties cultivated, in 2008 and 2009, under organic farming and integrated cultivation conditionswere analysed for their quality attributes, antioxidant activity and subjected to sensory evaluation.. Average size, weight, soluble solids,titratable acidity, total polyphenols, free radical scavenging capacity expressed as Trolox equivalent (TEAC), copper and zinc weredetermined in freshly harvested fruits. The obtained results indicated that, the principal component analysis can separate and distinguish theseasons of fruit production. The farming system seemed to have slight effect on quality the fruit as compared to varietal factors (genotypes).However, the total polyphenol content was uniformly less in 2009. Total polyphenols and free radical scavenging activity were significantlyhigher in Bosnian type sour cherries, and outstanding in Amarelle type cultivar ‘Pipacs’. There was no statistically significant differencebetween the sensory properties of cultivars tested by panels, except the case of ‘Pipacs’. The organolaptic investigation showed markedpreference to the fruits of Eva and Petri cultivars

Composition and sensory properties of sour cherry cultivars

Fruits of different sour cherry varieties cultivated, in 2008 and 2009, under organic farming and integrated cultivation conditions were analysed for their quality attributes, antioxidant activity and subjected to sensory evaluation.. Average size, weight, soluble solids, titratable acidity, total polyphenols, free radical scavenging capacity expressed as Trolox equivalent (TEAC), copper and zinc were determined in freshly harvested fruits. The obtained results indicated that, the principal component analysis can separate and distinguish the seasons of fruit production. The farming system seemed to have slight effect on quality the fruit as compared to varietal factors (genotypes). However, the total polyphenol content was uniformly less in 2009. Total polyphenols and free radical scavenging activity were significantly higher in Bosnian type sour cherries, and outstanding in Amarelle type cultivar ‘Pipacs’. There was no statistically significant difference between the sensory properties of cultivars tested by panels, except the case of ‘Pipacs’. The organolaptic investigation showed marked preference to the fruits of Eva and Petri cultivars

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience

Rituximab is a human/murine, chimeric anti-CD20 monoclonal antibody with established efficacy, and a favorable and well-defined safety profile in patients with various CD20-expressing lymphoid malignancies, including indolent and aggressive forms of B-cell non-Hodgkin lymphoma. Since its first approval 20 years ago, intravenously administered rituximab has revolutionized the treatment of B-cell malignancies and has become a standard component of care for follicular lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, and mantle cell lymphoma. For all of these diseases, clinical trials have demonstrated that rituximab not only prolongs the time to disease progression but also extends overall survival. Efficacy benefits have also been shown in patients with marginal zone lymphoma and in more aggressive diseases such as Burkitt lymphoma. Although the proven clinical efficacy and success of rituximab has led to the development of other anti-CD20 monoclonal antibodies in recent years (e.g., obinutuzumab, ofatumumab, veltuzumab, and ocrelizumab), rituximab is likely to maintain a position within the therapeutic armamentarium because it is well established with a long history of successful clinical use. Furthermore, a subcutaneous formulation of the drug has been approved both in the EU and in the USA for the treatment of B-cell malignancies. Using the wealth of data published on rituximab during the last two decades, we review the preclinical development of rituximab and the clinical experience gained in the treatment of hematologic B-cell malignancies, with a focus on the well-established intravenous route of administration. This article is a companion paper to A. Davies, et al., which is also published in this issue

Comprehensive analysis of human microRNA target networks

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) mediate posttranscriptional regulation of protein-coding genes by binding to the 3' untranslated region of target mRNAs, leading to translational inhibition, mRNA destabilization or degradation, depending on the degree of sequence complementarity. In general, a single miRNA concurrently downregulates hundreds of target mRNAs. Thus, miRNAs play a key role in fine-tuning of diverse cellular functions, such as development, differentiation, proliferation, apoptosis and metabolism. However, it remains to be fully elucidated whether a set of miRNA target genes regulated by an individual miRNA in the whole human microRNAome generally constitute the biological network of functionally-associated molecules or simply reflect a random set of functionally-independent genes.</p> <p>Methods</p> <p>The complete set of human miRNAs was downloaded from miRBase Release 16. We explored target genes of individual miRNA by using the Diana-microT 3.0 target prediction program, and selected the genes with the miTG score ≧ 20 as the set of highly reliable targets. Then, Entrez Gene IDs of miRNA target genes were uploaded onto KeyMolnet, a tool for analyzing molecular interactions on the comprehensive knowledgebase by the neighboring network-search algorithm. The generated network, compared side by side with human canonical networks of the KeyMolnet library, composed of 430 pathways, 885 diseases, and 208 pathological events, enabled us to identify the canonical network with the most significant relevance to the extracted network.</p> <p>Results</p> <p>Among 1,223 human miRNAs examined, Diana-microT 3.0 predicted reliable targets from 273 miRNAs. Among them, KeyMolnet successfully extracted molecular networks from 232 miRNAs. The most relevant pathway is transcriptional regulation by transcription factors RB/E2F, the disease is adult T cell lymphoma/leukemia, and the pathological event is cancer.</p> <p>Conclusion</p> <p>The predicted targets derived from approximately 20% of all human miRNAs constructed biologically meaningful molecular networks, supporting the view that a set of miRNA targets regulated by a single miRNA generally constitute the biological network of functionally-associated molecules in human cells.</p

Computational Prediction of Intronic microRNA Targets using Host Gene Expression Reveals Novel Regulatory Mechanisms

Approximately half of known human miRNAs are located in the introns of protein coding genes. Some of these intronic miRNAs are only expressed when their host gene is and, as such, their steady state expression levels are highly correlated with those of the host gene's mRNA. Recently host gene expression levels have been used to predict the targets of intronic miRNAs by identifying other mRNAs that they have consistent negative correlation with. This is a potentially powerful approach because it allows a large number of expression profiling studies to be used but needs refinement because mRNAs can be targeted by multiple miRNAs and not all intronic miRNAs are co-expressed with their host genes