MAPPA. Methodologies applied to archaeological potential Predictivity

The fruitful cooperation over the years between the university teaching staff of Univerità di Pisa (Pisa University), the officials of the Soprintendenza per i Beni Archeologici della Toscana (Superintendency for Archaeological Heritage of Tuscany), the officials of the Soprintendenza per i Beni Architettonici, Paesaggistici, Artistici ed Etnoantropologici per le Province di Pisa e Livorno (Superintendency for Architectural, Landscape and Ethno-anthropological Heritage for the Provinces of Pisa and Livorno), and the Comune di Pisa (Municipality of Pisa) has favoured a great deal of research on issues regarding archaeological heritage and the reconstruction of the environmental and landscape context in which Pisa has evolved throughout the centuries of its history. The desire to merge this remarkable know-how into an organic framework and, above all, to make it easily accessible, not only to the scientific community and professional categories involved, but to everyone, together with the wish to provide Pisa with a Map of archaeological potential (the research, protection and urban planning tool capable of converging the heritage protection needs of the remains of the past with the development requirements of the future) led to the development of the MAPPA project – Methodologies applied to archaeological potential predictivity - funded by Regione Toscana in 2010. The two-year project started on 1 July 2011 and will end on 30 June 2013. The first year of research was dedicated to achieving the first objective, that is, to retrieving the results of archaeological investigations from the archives of Superintendencies and University and from the pages of scientific publications, and to making them easily accessible; these results have often never been published or have often been published incompletely and very slowly. For this reason, a webGIS (“MappaGIS” that may freely accessed at http://mappaproject.arch.unipi.it/?page_id=452) was created and will be followed by a MOD (Mappa Open Data archaeological archive), the first Italian archive of open archaeological data, in line with European directives regarding access to Public Administration data and recently implemented by the Italian government also (the beta version of the archive can be viewed at http://mappaproject.arch.unipi.it/?page_id=454). Details are given in this first volume about the operational decisions that led to the creation of the webGIS: the software used, the system architecture, the organisation of information and its structuring into various information layers. But not only. The creation of the webGIS also gave us the opportunity to focus on a series of considerations alongside the work carried out by the MAPPA Laboratory researchers. We took the decision to publish these considerations with a view to promoting debate within the scientific community and, more in general, within the professional categories involved (e.g. public administrators, university researchers, archaeology professionals). This allowed us to overcome the critical aspects that emerged, such as the need to update the archaeological excavation documentation and data archiving systems in order to adjust them to the new standards provided by IT development; most of all, the need for greater and more rapid spreading of information, without which research cannot truly progress. Indeed, it is by comparing and connecting new data in every possible and, at times, unexpected way that research can truly thrive

Tonsillar carcinoma spreading metastases to central nervous system – Case report and literature review

We present a case report of a 51-year-old left-handed gentleman with a background of HPV 16-positive tonsil squamous cell carcinoma presenting with tonic-clonic seizure and a radiological diagnosis of secondary metastatic deposits. These were initially treated with Stereotactic RadioSurgery (SRS), and subsequently with surgery. Surgical resection was performed under general anaesthesia with right-sided temporal and parietal approaches. Both the parietal and temporal deposits were removed, while the intraventricular mass was intentionally left to avoid post-op deficits. Adjuvant radiotherapy and chemotherapy were administered post-op. The patient experienced a satisfactory recovery post-op and was re-operated for recurrence 4 months later. He maintained a good quality of life and an excellent performance status throughout, but unfortunately passed away in November 2018 due to septic complications. This case history stresses the difficulty in managing SCC with brain metastatic deposits. There are no current guidelines about the management of patients presenting with such a rare condition. More data is thus desirable in order to better define treatment guidelines and protocols when SCC brain metastases are present

Multiproxy archaeological investigation and Garden Archaeology in the Charterhouse of Calci (Tuscany, central Italy) and its territory: results and research data

A wide-ranging archaeological research programme at the Charterhouse and in the broader area of the Municipality of Calci has been performed since 2018. The archaeological research included the collection of legacy and aerial archaeology data, invasive and non-invasive investigations, as well as natural scientific analysis in the monastic complex. Special attention was paid to the archaeological investigations of three different monks’ cells gardens (the Prior’s, the Apothecary’s, and the Master’s), and stratigraphic excavations were combined with archeozoological and archaeobotanical analyses to define the horticultural practices implemented over the centuries of occupation of the Charterhouse. Among the three case studies, the most representative is the Prior’s meditation garden, where the excavation explored the phases prior to the construction of the building (14th century), the 18th-century renovation in the current form, and its abandonment at the end of the 20th century. Pollen analysis has allowed to reconstruct the richness of herbal species characterising an ever-blooming garden, with flowers and ornamental plants, such as roses, lilac, and water lilies, and also vegetables. According to charcoal and fruit-remain analyses, the Charterhouse exploited local hilly woods, satisfying the requirements of fuel by maquis and thermophilous deciduous forest. The agricultural practices included the cultivation of fruit trees, such as chestnut, olive, almond, and vine. Finally, archaeozoological analysis attests the domestic cat as the most frequent taxon in all contexts, probably common in the monastery as a pet and cell companion. This paper presents an overview and a discussion of the results of the investigations conducted and the complete archaeological dataset

Rational Use of Monoclonal Antibodies as Therapeutic Treatment in an Oncologic Patient with Long COVID

We present the case of a 76-year-old male patient persistently infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the setting of a stage IIIC cutaneous melanoma and non-Hodgkin’s lymphoma (NHL). Due to the persistent coronavirus disease 19 (COVID-19), all cancer treatments were discontinued. Because of the worsening of his clinical state and the persistence of SARS-CoV-2 positivity for more than six months, the patient was treated with sotrovimab, which was ineffective due to resistance mutations acquired during that time. In order to resume cancer treatment and make the patient free from SARS-CoV-2, an in vitro screening of Evusheld monoclonal antibodies (tixagevumab–cilgavimab) against the viral strains isolated from the subject was performed. The promising results obtained during in vitro testing led to the authorization of the off-label use of Evusheld, which made the patient negative for SARS-CoV-2, thus, allowing him to resume his cancer treatment. This study highlights the Evusheld monoclonal antibodies’ efficacy, not only in prevention but also in successful therapy against prolonged COVID-19. Therefore, testing neutralizing monoclonal antibodies in vitro against SARS-CoV-2 mutants directly isolated from patients could provide useful information for the treatment of people affected by long COVID

Gender effect on the Relation between Diabetes and Hospitalization for Heart Failure

Aims: Cardiovascular risk among diabetic patients is at least twice as much the one for nondiabetic individuals and even greater when diabetic women are considered. Heart failure (HF) is a common unfavorable outcome of cardiovascular disease in diabetes. However, since the comparison among sexes of heart failure prevalence in diabetic patients remains limited, this study is aimed at expanding the information about this point. Methods: We have evaluated the association between diabetes and HF by reviewing the medical records of all subjects discharged from the Internal Medicine and Cardiology Units of all hospitals in the Tuscany region, Italy, during the period January 2002 through December 2008. In particular we sought concomitance of ICD-9-CM codes for diabetes and HF. Results: Patients discharged by Internal Medicine were on average older, more represented by women, and had a lesser number of individuals coded as diabetic (p < 0.05 for all). Relative risk for HF (95 % CI) was signifi cantly higher in patients with diabetes, irrespective of gender 1.39 (1.36– 1.41) in males; 1.40 (1.37–1.42) in females. When the diabetes-HF association was analyzed according to decades of age, a “horse-shoe” pattern was apparent with an increased risk in 40–59 years old in female patients discharged by Internal Medicine. Conclusions: Although there is not a diff erence in the overall HF risk between hospitalized male and female diabetic patients, women have an excess risk at perimenopausal ag

MACROGLOSSIA AS A CAUSE OF ATYPICAL SWALLOWING: COMPARISON OF EVALUATION AND LOGOPEDIC TREATMENT BETWEEN BECKWITH-WIEDEMANN AND DOWN PATIENTS

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Predictive factors in GEP-NEN: The integrated role of Ki67, beta-catenin and morphology

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SARS-CoV-2 infection in cancer patients on active therapy after the booster dose of mRNA vaccines

The protective role against SARS-CoV-2 infection by the third booster dose of mRNA vaccines in cancer patients with solid malignancies is presently un- known. We prospectively investigated the occurrence of COVID-19 in cancer patients on active therapy after the booster vaccine dose. Methods: Cancer patients on treatment at the Center for Immuno-Oncology (CIO) of the University Hospital of Siena, Italy, and health care workers at CIO who had received a booster third dose of mRNA vaccine entered a systematic follow-up monitoring period to prospectively assess their potential risk of SARS-CoV-2 infection. Serological and microneu- tralization assay were utilized to assess levels of anti-spike IgG, and of neutralizing antibodies to the SARS-CoV-2 Wild Type, Delta and Omicron variants, respectively, after the booster dose and after negativization of the nasopharyngeal swab for those who had developed COV- ID-19. Results: Ninety cancer patients with solid tumors on active treatment (Cohort 1) and 30 health care workers (Cohort 2) underwent a booster third dose of mRNA vaccine. After the booster dose, the median value of anti-spike IgG was higher (p Z 0.009) in patients than in healthy subjects. Remarkably, 11/90 (12%) patients and 11/30 (37%) healthy subjects tested positive to SARS-CoV-2 infection during the monitoring period. Similar levels of anti-spike IgG and of neutralizing antibodies against all the investigated variants, with geometric mean titers of neutralizing antibodies against the Omicron being the lowest were detected after the booster dose and after COVID-19 in both Cohorts. Conclusions: The occurrence of SARS-CoV-2 infection we observed in a sizable proportion of booster-dosed cancer patients and in healthy subjects during the Omicron outbreak indicates that highly specific vaccines against SARS-CoV-2 variants are urgently required