28 research outputs found
Nitro-fatty acids serve as regulators of classically and alternatively activated macrophages
Dose Distribution Outside the Target Volume for 170-Mev Proton Beam
Dose delivered outside the proton field during radiotherapy can potentially lead to secondary cancer development. Measurements with a 170-MeV proton beam were performed with passive detectors (track etched detectors and thermoluminescence dose-meters) in three different depths along the Bragg curve. The measurement showed an uneven decrease of the dose outside of the beam field with local enhancements. The major contribution to the delivered dose is due to high-energy protons with linear energy transfer (LET) up to 10 keV mu m(-1). However, both measurement and preliminary Monte Carlo calculation also confirmed the presence of particles with higher LET
New possibilities in treatment of failing heart: Focus on innate immunity and inflammatory signalling pathways
Poster session 11: Space dosimetry and environment dosimetry measurements using timepix in mixed radiation fields induced by heavy ions; comparison with standard dosimetry methods
Objective of our research was to explore capabilities of Timepix for its use as a single dosemeter and LET spectrometer in mixed radiation fields created by heavy ions. We exposed it to radiation field (i) at heavy ion beams at HIMAC, Chiba, Japan, (ii) in the CERN\u27s high-energy reference field (CERF) facility at Geneva, France/Switzerland, (iii) in the exposure room of the proton therapy laboratory at JINR, Dubna, Russia, and (iv) onboard aircraft. We compared the absolute values of dosimetric quantities obtained with Timepix and with other dosemeters and spectrometers like tissue-equivalent proportional counter (TEPC) Hawk, silicon detector Liulin, and track-etched detectors (TEDs). \ua9 The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology
DOSIS & DOSIS 3D: radiation measurements with the DOSTEL instruments onboard the Columbus Laboratory of the ISS in the years 2009–2016
The natural radiation environment in Low Earth Orbit (LEO) differs significantly in composition and energy from that found on Earth. The space radiation field consists of high energetic protons and heavier ions from Galactic Cosmic Radiation (GCR), as well as of protons and electrons trapped in the Earth’s radiation belts (Van Allen belts). Protons and some heavier particles ejected in occasional Solar Particle Events (SPEs) might in addition contribute to the radiation exposure in LEO. All sources of radiation are modulated by the solar cycle. During solar maximum conditions SPEs occur more frequently with higher particle intensities. Since the radiation exposure in LEO exceeds exposure limits for radiation workers on Earth, the radiation exposure in space has been recognized as a main health concern for humans in space missions from the beginning of the space age on. Monitoring of the radiation environment is therefore an inevitable task in human spaceflight. Since mission profiles are always different and each spacecraft provides different shielding distributions, modifying the radiation environment measurements needs to be done for each mission. The experiments “Dose Distribution within the ISS (DOSIS)” (2009–2011) and “Dose Distribution within the ISS 3D (DOSIS 3D)” (2012–onwards) onboard the Columbus Laboratory of the International Space Station (ISS) use a detector suite consisting of two silicon detector telescopes (DOSimetry TELescope = DOSTEL) and passive radiation detector packages (PDP) and are designed for the determination of the temporal and spatial variation of the radiation environment. With the DOSTEL instruments’ changes of the radiation composition and the related exposure levels in dependence of the solar cycle, the altitude of the ISS and the influence of attitude changes of the ISS during Space Shuttle dockings inside the Columbus Laboratory have been monitored. The absorbed doses measured at the end of May 2016 reached up to 286 μGy/day with dose equivalent values of 647 μSv/day
Intercomparison of personal and ambient dosimeters in extremely high-dose-rate pulsed photon fields
Recent advances in laser driven accelerators boosted the development of high dose-rate fast pulsed systems all over the world. The stray radiation comprises primarily high-energy photons, resulting in extremely high dose rates within pico-/femto-second pulses. Dose measurements in such conditions have to be evaluated to validate methods. To tackle this challenge the EUropean RAdiation DOSimetry Group (EURADOS) started a program of dosimeters intercomparison, with a progressive approach, starting by a first evaluation in fields with ÎĽs pulse duration. The first comparison took place at the Lausanne University Hospital Center with an electron LINAC in Sept. 2017 involving 7 European institutes. Several passive and active dosimeters were tested with a tunable air kerma per pulse of the order of MGy/h. All instruments, except electrets, did not show any dose rate dependence, thus being selected as possible candidates for further studies
DOSIS & DOSIS 3D: long-term dose monitoring onboard the Columbus Laboratory of the International Space Station (ISS)
The radiation environment encountered in space differs in nature from that on Earth, consisting mostly of highly energetic ions
from protons up to iron, resulting in radiation levels far exceeding the ones present on Earth for occupational radiation workers.
Since the beginning of the space era, the radiation exposure during space missions has been monitored with various active and
passive radiation instruments. Also onboard the International Space Station (ISS), a number of area monitoring devices provide
data related to the spatial and temporal variation of the radiation field in and outside the ISS. The aim of the DOSIS (2009–2011)
and the DOSIS 3D (2012–ongoing) experiments was and is to measure the radiation environment within the European Columbus
Laboratory of the ISS. These measurements are, on the one hand, performed with passive radiation detectors mounted at 11 locations
within Columbus for the determination of the spatial distribution of the radiation field parameters and, on the other, with two
active radiation detectors mounted at a fixed position inside Columbus for the determination of the temporal variation of the radiation
field parameters. Data measured with passive radiation detectors showed that the absorbed dose values inside the Columbus
Laboratory follow a pattern, based on the local shielding configuration of the radiation detectors, with minimum dose values
observed in the year 2010 of 195–270 lGy/day and maximum values observed in the year 2012 with values ranging from
260 to 360 lGy/day. The absorbed dose is modulated by (a) the variation in solar activity and (b) the changes in ISS altitude
REFLECT – Research flight of EURADOS and CRREAT: Intercomparison of various radiation dosimeters onboard aircraft
Aircraft crew are one of the groups of radiation workers which receive the highest annual exposure to ionizing radiation. Validation of computer codes used routinely for calculation of the exposure due to cosmic radiation and the observation of nonpredictable changes in the level of the exposure due to solar energetic particles, requires continuous measurements onboard aircraft. Appropriate calibration of suitable instruments is crucial, however, for the very complex atmospheric radiation field there is no single reference field covering all particles and energies involved. Further intercomparisons of measurements of different instruments under real flight conditions are therefore indispensable. In November 2017, the REFLECT (REsearch FLight of EURADOS and CRREAT) was carried out. With a payload comprising more than 20 different instruments, REFLECT represents the largest campaign of this type ever performed. The instruments flown included those already proven for routine dosimetry onboard aircraft such as the Liulin Si-diode spectrometer and tissue equivalent proportional counters, as well as newly developed detectors and instruments with the potential to be used for onboard aircraft measurements in the future. This flight enabled acquisition of dosimetric data under well-defined conditions onboard aircraft and comparison of new instruments with those routinely used. As expected, dosimeters routinely used for onboard aircraft dosimetry and for verification of calculated doses such as a tissue equivalent proportional counter or a silicon detector device like Liulin agreed reasonable with each other as well as with model calculations. Conventional neutron rem counters underestimated neutron ambient dose equivalent, while extended-range neutron rem counters provided results comparable to routinely used instruments. Although the responses of some instruments, not primarily intended for the use in a very complex mixed radiation field such as onboard aircraft, were as somehow expected to be different, the verification of their suitability was one of the objectives of the REFLECT. This campaign comprised a single short flight. For further testing of instruments, additional flights as well as comparison at appropriate reference fields are envisaged. The REFLECT provided valuable experience and feedback for validation of calculated aviation doses