1 research outputs found
Nitrous Oxide and Nitrous Oxide-Free Low-Flow Anesthesia Using Bispectral Index Monitoring: Effects on Hemodynamics, Recovery Times, Volatile Anesthetic Consumption and Costs
Aim: In this study, we aimed to compare the effects of desfluraneN2O
and desflurane-fentanyl combinations on hemodynamics,
recovery times, volatile anesthetic consumption and costs in low-flow
desflurane anesthesia by bispectral index (BIS) monitoring of depth
of anesthesia.
Methods: After approval of ethics committee and obtaining patient
consents, 60 patients were divided into two equal groups randomly.
Non-invasive blood pressure measurement, ECG, SpO2 and BIS were
monitored. All patients received 10 L .min-1 100% oxygen with mask
for 5 minute before intubation. 2 mg.kg-1 propofol, 2 μg.kg-1 fentanyl
and 0.6 mg.kg-1 rocuronium bromide were administered at
induction in both groups. Desfluran 6% was chosen for anesthesia
maintenance. Group 1 received 50% O2-N2O mixture in 6 L.min-1
and Group 2 received 50% O2-air mixture in 6 L.min-1 as carrier gas.
Low-flow anesthesia (1 L.min-1) was started after a 10-min period of
initial high flow (6 L.min-1). In Group 2, infusion of fentanyl was
begun in 1 μg.kg.hour-1 rate. Desflurane level was adjusted at a main
BIS value of 40-60. Blood pressure, heart rate, FiO2, etO2, FiN22,
EtN2O, FiCO2, EtCO2, Fidesfluran and Etdesflurane were recorded.
Results: There were no significant differences between the two
groups in terms of heart rate, arterial blood pressure, settings of
desfluran and recovery time. BIS values (p<0.001) and anesthetic
agent costs (p<0.001) were higher in Group 2.
Conclusion: Using fentanyl infusion instead of nitrous oxide in low
flow-anesthesia with desflurane did not alter the hemodynamic
parameters. Fentanyl infusion with medical air-oxygen as carrier gas
is an alternative technique, but increases BIS values and anesthetic
agent costs. (The Medical Bulletin of Haseki 2010; 48: 132-8