Kalkinmaya farkli bir bakis: Iyi olus (Views on well-being)

Well-being is a broad concept which covers development, income, education, marriage, family life etc. When speaking about well-being in a nation we denote how well its citizens live. There are two approaches to assess how well people live. One is to consider to what extent the country provides conditions deemed essential for a good life, which is called presumed approach. The other approach is to asses how well people thrive which we call apparent approach. Moreover when speaking about well-being, we use objective, subjective and mixed indicators. Subjective indicators are emotions which are outcomes of experiences whereas objective indicators comprise factors which generates emotions. Mixed indicators covers both objective and subjective indicators

Load transmission characteristics of limited carpal fusions: a two-dimensional finite element study

© 2014, Springer-Verlag France.Although limited carpal fusion is a choice of treatment in several wrist disorders, little is known about the biomechanics of these procedures, especially the loads carried by the ligaments. In a finite element study, four types of limited carpal fusions (scaphotrapeziotrapezoid, capitohamate, four corner fusion with and without scaphoid excision) were simulated and the loads carried by the ligaments were recorded. Measurements were repeated with and without implantation. The load transmission through the ligaments varied by the type of the fusion but, radioscaphoid and long radiolunate ligaments carried significantly more loads if not excised during the operation. Implantation did not affect the results in most cases. The model of the present study may be useful in preoperative planning

Interleukin-10 gene polymorphism in chronic hepatitis B virus infection

Gulkesen, Kemal Hakan/0000-0002-2477-2481WOS: 000256716300267

Antistreptococcal Response is Exaggerated in Children with Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is an autosomal recessive disorder. Although the pathogenesis of the disease is not yet completely understood, enhanced acute-phase responsiveness is considered to be one of the most important mechanisms. The presence of high levels of antistreptolysin O (ASO) antibodies and streptococcus-associated diseases, such as acute poststreptococcal glomerulonephritis (AGN) and acute rheumatic fever (ARF), has been reported in patients with FMF. In order to better understand the effect of FMF on antistreptococcal antibody response, we measured ASO and antideoxyribonuclease B (anti-DNAse B) levels in patients with FMF and compared them with those in healthy controls. The study consisted of two parts. In the first step, antistreptococcal antibody levels were analysed in 44 patients with FMF and 165 healthy children who had no history or clinical evidence of upper respiratory tract infection (URTI) for the last 4 months. In the second step, antistreptococcal antibody levels were measured in 15 patients with FMF and 22 healthy controls in response to documented group A β-haemolytic streptococcal pharyngitis. In the first part of the study, ASO and anti-DNAse B levels in patients with FMF were found to be significantly higher than those in healthy controls (P<0.001). In the second part, ASO and anti-DNAse B titres were found to be significantly higher in patients with FMF than in controls (P<0.001 and <0.05, respectively) 4 weeks after a positive throat culture. We concluded that patients with FMF have an exaggerated response to streptococcal antigens and might be prone to poststreptococcal non-suppurative complications, such as ARF