Chagas' disease reactivation with skin symptoms in a patient with kidney transplant

Immunodepressed patients in the intermediate phase of Chagas' disease may undergo reactivation of the disease together with atypical symptoms. The case of an immunodepressed kidney transplant patient with reactivation of Chagas' disease with skin symptoms is reported. A 65-year-old man presented with infiltrated erythematous lesions on the anterior aspect of the right thigh of 2 weeks' duration. The lesions later extended to the abdomen, thorax, and lower limbs. In the histologic skin examination, amastigotes and Trypanosoma cruzi trypoamastigotes were observed. A fresh smear showed positive parasitemia. Using the Strout hemoconcentration method, multiple Trypanosoma cruzi trypoamastigotes with motility could be seen. Polymerase chain reaction was positive for Trypanosoma cruzi. An immunofluorescence test was positive (1:64) and there was hemoagglutination (1:32). Treatment was started with benznidazole, 7mg/kg/day. The patient did not evolve favorably and died 20 days after hospitalization. Skin lesions may be a manifestation of the reactivation of Chagas' disease in immunosuppressed patients. All patients with positive Chagas serology who require immunosuppressant drugs should receive specific treatment for Chagas' disease.Fil: Gallerano, Verónica. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Consigli, Javier Enrique. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Pereyra, Susana. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Gómez Zanni, Susana. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Danielo, Cristian. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Gallerano, Rafael H. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentin

T-cell intestinal lymphoma in a female patient with dermatitis herpetiformis (Düring-Brocq disease) [Linfoma intestinal de células T en una paciente con dermatitis herpetiforme (Enfermedad de Dühring-Brocq)]

Dermatitis herpetiformis (DH) or Düring-Brocq disease, a particularly pruritic bullous skin disease, is part of a spectrum of gluten-sensitive disorders that includes celiac disease. The risk for lymphoma is increased in both dermatitis herpetiformis and in celiac disease, predominantly T-cell lymphomas. We report the case of a patient with dermatitis herpetiformis and celiac disease who developed intestinal lymphoma.Fil: Danielo, Cristian. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Consigli, Javier Enrique. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Gómez Zanni, Susana. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Gallerano, Verónica. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Trakal, Juan José. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; ArgentinaFil: Guidi, Andrés Emilio. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentin