Histological Evaluation of the Nasal Swell Body in Allergic Patients

Objective:To evaluate the histopathology of the nasal swell body (NSB) mucosa in allergic patients in comparison with non-allergic patients.Methods:Our study evaluated 25 allergic and 25 non -allergic patients who underwent septoplasty and bilateral inferior turbinate reduction. The NSB was evaluated via tomographic images and histopathologically. The thickness of the NSB and the glandular structures, arterial structures, capillary and venous sinusoids was measured in both groups. The data were then summarized as the relative proportion of each tissue type, given in percentage form.Results:The histopathological examination of the nasal mucosa revealed glandular and vascular structures in the NSB, inferior turbinate and septal mucosa. Although the NSB mucosa was thicker in allergic patients than in non-allergic patients, the incidence of glandular cells was increased primarily at the NSB in both allergic and non -allergic patients. There were no significant differences between the allergic and non-allergic groups (p>0.05). Venous sinusoids were more common in the inferior turbinate than in the NSB. There was no difference in the predominance of venous sinusoids between allergic and non-allergic patients.Conclusion:The NSB is thicker in allergic patients than in non-allergic patients. However, the NSB is rich in glandular cells in both allergic and non-allergic patients. Therefore, any changes in this region may lead to changes in humidification, dysfunction and nasal obstruction

Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?

<p>Summary</p> <p>Giant cell tumor, excluding its prototype in bone, is usually a benign but local aggressive neoplasm originating from tendon sheath or soft tissue. Malignant behavior is uncommon. Visceral organ involvement including urinary bladder is rare. Giant cell tumors in visceral organs usually accompany epithelial tumors and the clinical behavior of giant cell tumor in urinary bladder is similar to its bone counterpart. Here, we report two cases of giant cell tumor located in urinary bladder in comparison with nine reported cases in the English literature. Concurrent noninvasive urothelial carcinoma was also described in all these previous reports and only one patient with follow-up died of disease. One of the two cases we present had no concurrent urothelial tumor at the time of diagnosis but had a history of a low grade noninvasive urothelial carcinoma with three recurrences. The histology of these two cases was similar to the giant cell tumor of bone and composed of oval to spindle mononuclear cells with evenly spaced osteoclast-like giant cells. Immunohistochemically, the giant cells showed staining with osteoclastic markers including CD68, TRAP, and LCA. Immunohistochemical expression of vimentin, CD68, LCA, and smooth muscle actin in mononuclear cells supported a mesenchymal origin with histiocytic lineage. The histologic and immunohistochemical properties in our cases as well as their clinical courses were consistent with a giant cell tumor. Consequently, tumors in urinary bladder showing features of giant cell tumor of bone may also be considered and termed "giant cell tumor".</p

Histologic features of spindle cell lipoma and problems in the differential diagnosis

AMAÇ: İğsi hücreli lipomun histolojik ve tipik immunhistokimyasal özelliklerini araştırmak ve diğer subkutan yerleşimli benzer histolojik ve immunhistokimyasal özellikleri olan neoplazmlarla ayırıcı tanısını yapmaktır. YÖNTEMLER: İstanbul Eğitim ve Araştırma Hastanesi patoloji laboratuarında lipom tanısı almış 3100 olguda son Dünya Sağlık Örgütü Yumuşak Doku Tümörleri Sınıflamasına göre alt tipler belirlendi ve bunların içinden 22 İHL çalışmaya alındı. 22 iğsi hücreli lipom olgusunda klinik (yaş, lokalizasyon, cinsiyet, nüks), morfolojik özellikler (tümör boyutu, alt tip, histoloji, mast hücre varlığı ve immunhistokimya), tümörlerin natürü ve ayrıcı tanı problemleri değerlendirildi. BULGULAR: 3100 lipomun alt tiplere göre dağılımı şu şekildeydi: 2864 klasik lipom (%90), 293 anjiyolipom (%9), 1 kondroid lipom (%0.03), 1 miyolipom (%0.03 ve 22 iğsi hücreli lipom (% 0.7). 22 iğsi hücreli lipomların 9’u fibröz, 3’ü miksoid, 1’i anjiyomatoid ve 9’u nonfibröz alt tipti. Erkek kadın oranı 18/4 olarak belirlendi. Olguların 2’si sırt, 3’ü omuz, 1’i ön kol, 1’i oral olup 15’ü baş-boyun bölgesinde lokalize idi. Ortalama tümör çapı 3.2 cm olup en büyük ve küçük çaplar 1 cm ve 6.1 cm olarak ölçüldü. Fibromatöz alt tipte belirgin olmak üzere Toluidin blue boyasıyla her olguda mast hücresi mevcuttu. Mast hücre sayısı on büyük büyütme alanında ortalama 23 olarak bulundu. S–100 tüm iğsi hücrelerde negatif ve yağ hücrelerinde pozitif olarak tespit edildi. CD34 olguların 21’inde pozitif, 1’inde negatif bulundu. Hiçbir olguda nüks izlenmedi. SONUÇ: İğsi hücreli lipom, subkutan lokalizasyonlu, iyi sınırlı, iğsi hücreli komponenti CD34 pozitif, mast hücrelerinden zengin bir tümör olup birçok subkutan tümörle ayırıcı tanı yapılmasını gerektiren nadir bir antitedir.OBJECTIVE: To investigate the histologic and immunohistochemical properties of spindle cell lipoma and to make its differential diagnosis from other subcutaneous neoplasms having similar histologic or immunohistochemical charecteristics. METHODS: 3100 cases of lipoma diagnosed in the Pathology Laboratory of İstanbul Educational and Research Hospital were reclassified according to the recent classification of Soft Tissue Tumors by World Health Organization and 22 spindl cell lipomas were included in the study. Clinical (age, gender, location, and recurrences) and morphologic features (tumor size, subtype, histology, presence of mast cells, and immunohistochemistry) as well as tumor nature and problems in differential diagnosis were evaluated. RESULTS: The histologic subtypes of 3100 lipomas were as follows: 2864 classical lipoma (90 %), 293 angiolipoma (9 %), 1 chondroid lipoma (0.03 %), 1 myolipoma (0.03 %) and 22 spindl cell lipoma (% 0.7). Of the 22 spindl cell lipoma 9 were fibrous, 3 myxoid, 1 angiomatoid and 9 non-fibrous subtypes. Male to female ratio was 18: 4. 2 cases were localized in dorsal region, 3 in shoulders, 1 in forearm, 1 in oral cavity and 15 in head and neck. Average tumor diameter was 3.2 cm ranging from 1 to 6.1 cm. Mast cells highligtened by Toluidin blue were seen in all cases, most prominently in the fibrous subtype. Mast cell count in 10 high power field was 23. S&amp;#8211;100 was negative in all spindle cells while lipomcytes were positive. CD34 was positive in 21 cases and negative in 1 case. No case recurred. CONCLUSION: Spindl cell lipoma is a subcutaneous, well-circumscribed tumor rich in mast cells with a CD34+ spindle cell component and is an uncommon entity requiring differential diagnosis with several subcutaneous tumors

Placental mesenchymal dysplasia clinically diagnosed as partial hydatidiform mole: Case report

Plasental mezenkimal displazi nadir görülen bir plasenta anomalisidir. Plasenta normalden büyük olup kistik villuslar ve genişlemiş kalın duvarlı damarlar mevcuttur. Bu anomalinin önemi klinik ve patolojik olarak parsiyel mol hidatiforma benzemesi ve genellikle Beckwith- Wiedemann sendromu ile birliktelik göstermesidir. Doğum öncesi rutin takiplerinde parsiyel mol hidatiform tanısı alan plasental mezenkimal displazi olgusu, plasenta dışında anomalisi olmayan 20. vaka olması ve nadir görülmesi nedeniyle sunulmuştur.Placental mesenchymal dysplasia is a rare placental abnormality. Placenta is found to be enlarged with cystic villi and dilated thick vascular structures. Importance of this abnormality is the clinical and morphological similarity to the partial hydatidiform mole and presentation with Beckwith- Wiedemann syndrome. Our case was diagnosed as partial hydatidiform mole in her rutin pregnancy controls. This is the 20. case in literature that had not any extra-placental abnormality

ALIŞILMADIK BİR HODGKİN DIŞI LENFOMA PREZENTASYONU: DİZDE LENFOMA

Agresif Hodgkin dışı lenfoma (HDL) olgularının %40’ını diffüz büyük B hücreli lenfoma (DBBHL) alt grubu oluşturur. DBBHL başlığı altında, klinik seyir, prognoz ve tedavi yanıtı bakımından farklılıklar gösteren bir dizi hastalık toplanmıştır; bunlar klinikte değişik bulgularla karşımıza çıkabilirler. Aşağıda sol dizindeki şişlik nedeniyle araştırılırken agresif HDL tanısı alan bir olgu sunulmuştur

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three-dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high-grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow-up period was 20 months (range, 6–54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease-free. In conclusion, cytology is an important tool for the diagnosis and management of MPC