Activin/follistatin system in grass carp pituitary cells: Regulation by local release of growth hormone and luteinizing hormone and its functional role in growth hormone synthesis and secretion

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Clinical features, management, and prognostic factors of status epilepticus in Chinese

Poster PresentationINTRODUCTION: Status epilepticus (SE) is a neurological emergency with significant mortality and morbidity. There are currently limited data regarding the causes and outcomes of SE in our locality, and identification of prognostic factors, especially those available at presentation, could lower risk of under- or over-treatment in SE. METHODS: We retrospectively studied the clinical characteristics, management, and clinical outcome of adults diagnosed with incident SE, excluding episodes due to cerebral anoxia, at a regional hospi…published_or_final_versio

Grass carp follisatin: Molecular cloning, functional characterization, dopamine D1 regulation at pituitary level and implication in growth hormone regulation. (as PI & corresponding author, impact factor: 3.675 / SJR ranking: top 5.6% of total)

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Prognosis after Status Epilepticus

Session P07 - Epilepsy: Clinical Epilepsy: abstract P07.175OBJECTIVE: To determine the clinical characteristics and prognostic factors of status epilepticus (SE) in Hong Kong. BACKGROUND: SE is a neurological emergency with significant mortality and morbidity. There is currently limited data regarding the causes and outcomes of SE in our locality. DESIGN/METHODS: We retrospectively studied the clinical characteristics, clinical outcome of adults diagnosed with convulsive SE and managed at a regional hospital in Hong Kong during January 1st 2007 – December 31st 2011. RESULTS: A total of 38 patients with convulsive SE were identified during the study period. The mean age was 58 years (range 21-92 years) and 61% were males. Underlying cerebrovascular disease (34%), poor compliance to anti-convulsants in patients with known epilepsy (16%) and infection of the central nervous system (11%) were the main causes of convulsive SE. SE was associated with 21% mortality during hospitalization period and 32% mortality within 6-months of admission. Age 65 years, prior history of seizures, a higher blood glucose level during SE and a Status Epilepticus Severity Score (STESS) 4 were associated with 6-month mortality (p<0.05). Multi-variate analysis subsequently identified a STESS 4 as an independent predictor of poor prognosis (p=0.03). CONCLUSIONS: Convulsive SE in adults is most commonly due to underlying cerebrovascular disease and is associated with a high mortality. The STESS is a useful tool in predicting 6-month mortality.link_to_OA_fulltex