Assessment of Nuchal Translucency Nasal Bone and Ductus Venosus Flow in the First Trimester: Pregnancy Outcomes

OBJECTIVE: To report the first trimester prenatal obstetric ultrasonography findings and pregnancy outcomes. STUDY DESIGN: This study was designed as a retrospective cohort one. Seven-hundreds twelve (n=712) singleton pregnant women attending to Simav –Kütahya Government Hospital between January 2008 and December 2011 for the routine first trimester screening and standard obstetric ultrasound examination were enrolled retrospectively. Pregnancy outcomes of these pregnancies were reported. RESULTS: The nasal bone was present in 704 (98.8%), absent in 4 (0.6%) and was not clearly evaluable in 4 (0.6%) patients. Blood flows in ductus venosus (DV) were normal in 609 (85.5%), reversed in 15 (2.1%) and not measurable in 88 (12.4%) of fetuses. We had 4 fetuses with cardiac anomaly. Among these 4 fetuses, we noted NT≥3.5 mm in 3 fetuses, absence of nasal bone in 3 fetuses and abnormal DV flow in 2 fetuses. We had 3 fetuses with Down syndrome. Among these 3 fetuses, we noted NT≥3.5 mm in 1 fetus, absence of nasal bone in 1 fetus and abnormal DV flow in 1 fetus. CONCLUSION: We reported our first trimester standard obstetric ultrasonographic results and pregnancy outcomes. We noted that the prenatal diagnosis of cardiac anomalies and Down syndrome may be possible via assessment of NT and DV flow

The Safety of Ondansetron and Chlorpromazine for Hyperemesis Gravidarum in First Trimester Pregnancy

OBJECTIVE: To evaluate the pregnancy outcome of women with nausea and vomiting of pregnancy (NVP) who were treated with either ondansetron or chlorpromazine. STUDY DESIGN: This retrospective study included 185 women who were hospitalized in the first trimester for treatment of NVP and treated with either ondansetron or chlorpromazine between January 2006 and March 2011 at Simav Government Hospital. We evaluated the pregnancy outcome including birth weight, pregnancy induced hypertension, preterm birth and major congenital malformations. RESULTS: In the ondansetron group 4 (4%) low birth weight newborn, 9 (9%) preterm birth and 1 (1%) congenital anomaly, while in chlorpromazine group 1 (1.2%) low birth weight newborn, 9 (10.6%) preterm birth and 4 (4.7%) congenital anomalies were observed. CONCLUSION: The malformation risk for both drugs found to be similar to baseline. Although the sample size was small, both drugs found to be safe to use in first trimester for NVP

Prognostic Significance of Preterm Isolated Decreased Fetal Movement

Objective: Our aim is to evaluate the prognostic significance of isolated, preterm decreased fetal movement following normal initial full diagnostic workup. Study design: A retrospective observational study was conducted at a tertiary centre. The applied protocol was approved by the Medical Research Ethics Department of the hospital where the research was conducted. Obstetrics outcomes of preterm- and term-decreased fetal movement were compared following an initial, normal diagnostic work up. Evaluated outcomes were birth weight, mode of delivery, stillbirth rate, induction of labour, development of gestational hypertension, small for gestational age and oligohydramnios, polyhydramnios during the follow up period. Result: Obstetric complications related to placental insufficiency develops more frequently for decreased fetal movement in preterm cases with respect to that of in term cases. Following the diagnosis of decreased fetal movement, pregnancy hypertension occurred in 17% of preterm decreased fetal movement cases and in 4.7% of term decreased fetal movement cases. Fetal growth restriction developed in 6.6% of preterm decreased fetal movement and in 2.3% of term decreased fetal movement. Amniotic fluid abnormalities more frequently developed in preterm decreased fetal movement. Conclusion: Following an initial normal diagnostic workup, preterm decreased fetal movement convey a higher risk for the development of pregnancy complications associated with placental insufficiency. The patient should be monitored closely and management protocols must be developed for initial normal diagnostic workups in cases of preterm decreased fetal movement