Histological and hitochemical studies on human fetal membranes

1. In the stage later than the middle stage of pregnancy, morphological differences appear between the amniotic epithelial cells of placenta and those of the free part and the majority of cases the amniotic epithelial cells of placenta present more marked columnar shape than those in the surrounding area of ruptured orifice or those in the vicinity of placenta. However, there still remains a question whether or not such a phenomena is directly related to the secretory function of the placenta amniotic epithelium. 2. It seems that amniotic epithelial cells divide and multiply themselves by mitosis at least in the early and middle stages when their functions are at height. 3. Even in the stage later than the middle stage generally the amniotic epithelium of placenta is consisted of a single layer of columnar epithelial cells, and therefore, the author cannot agree to Forssell's theory. 4. In glycogen and lipid stainings, the amniotic epithelial cell layer shows more striking changes with the progress of gestational month when compared with those cells in other layers. 5. Glycogen in the amniotic epithelial cell layer is abundant in the early and middle stages of pregnancy, and it rapidly decreases near the late stage. Lipid granules on the contrary are less in the early stage, and start to appear in the middle stage, increasing rapidly towards the late stage. In general, the regressive degeneration picture of the late stage is not distinct histologically, but assuming glycogen to represent the cell activity and the lipid deposit to mean just the reverse, the amniotic epithelium functionally seems to fall into regressive degeneration from the middle stage. Other layers of fetal membranes likewise undergo fatty degeneration as the pregnancy progresses from the middle stage to the late stage. 6. There still remain problems to be solved on the question what role this regressive degeneration of the amniotic epithelial cell layer plays in de Watteville's theory, &#34;Labor originates from the fetal membranes&#34;. However, granular PAS-positive substances in the amniotic epithelium are glycogen, and it seems difficult to connect simply the existence or non-existence of PAS-positive granules or Sudan-positive granules directly with the continuation or interruption of pregnancy.</p

インドシナ サンゴク ノ カジン カキョウ シャカイ ノ ヘンヨウ

大阪大學中國文化論壇 討論文件Discussion Papers in Contemporary China Studies, Osaka University Forum on Chin

Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development

Urodele amphibians such as Japanese common newts have a remarkable ability to regenerate their injured neural retina, even as adults. We found that hematological- and neurological-expressed sequence 1 (Hn1) gene was induced in depigmented retinal pigment epithelial (RPE) cells, and its expression was maintained at later stages of newt retinal regeneration. In this study, we investigated the distribution of the HN1 protein, the product of the Hn1 gene, in the developing retinas. Our immunohistochemical analyses suggested that the HN1 protein was highly expressed in an immature retina, and the subcellular localization changed during this retinogenesis as observed in newt retinal regeneration. We also found that the expression of Hn1 gene was not induced in mouse after retinal removal. Our results showed that Hn1 gene can be useful for detection of undifferentiated and dedifferentiated cells during both newt retinal development and regeneration

Risk factors for cognitive dysfunction after coronary artery bypass graft surgery in patients with type 2 diabetes

ObjectivesThe mechanisms of postoperative cognitive dysfunction in patients with diabetes after coronary artery bypass grafting are not fully understood. We sought to determine which type 2 diabetes–related factors contributed to postoperative cognitive dysfunction at 7 days and 6 months after coronary artery bypass grafting.MethodsOne hundred eighty patients with type 2 diabetes who were scheduled for elective coronary artery bypass grafting were studied. As a control group, 100 patients without diabetes mellitus matched for age, sex, and educational level were examined. Hemodynamic parameters (arterial and jugular venous blood gas values) were measured during cardiopulmonary bypass. All patients underwent a battery of neurologic and neuropsychologic tests the day before surgery, 7 days after surgery, and 6 months after surgery.ResultsAge (odds ratio 1.5, 95% confidence interval 1.3-1.8, P = .03), presence of hypertension (odds ratio 1.8, 95% confidence interval 1.3-2.0, P = .01), jugular venous oxygen saturation less than 50% time (odds ratio 1.5, 95% confidence interval 1.1-2.0, P = .045), presence of ascending aorta atherosclerosis (odds ratio 1.5, 95% confidence interval 1.1-2.6, P = .01), diabetic retinopathy (odds ratio 2.0, 95% confidence interval 1.3-3.0, P = .01), and insulin therapy (odds ratio 2.0, 95% confidence interval 1.3-3.0, P = .05), were associated with cognitive impairment at 7 days. Insulin therapy (odds ratio 2.0, 95% confidence interval 1.3-3.8, P = .01), diabetic retinopathy (odds ratio 1.3, 95% confidence interval 1.2-2.9, P < .01), and hemoglobin A1c (odds ratio 1.9, 95% confidence interval 1.3-3.1, P = .047) were associated with cognitive impairment at 6 postoperative months.ConclusionsInsulin therapy, diabetic retinopathy, and hemoglobin A1c were factors in cognitive impairment at 7 days and 6 months after coronary artery bypass grafting in patients with type 2 diabetes

Measuring the Effects of Zen Training on Quality of Life and Mental Health Among Japanese Monk Trainees: A Cross-Sectional Study

Objective: Previous studies have reported that the practice of meditation can have beneficial physiologic and mental effects. Therefore, Zen trainees who regularly practice meditation might have high quality-of-life scores and high levels of general mental health; however, no previous study has tested these relationships. This article reports on a study that examined how rigorous professional training affected the International Quality of Life (QOL) Assessment Short Form-36 (SF-36) and General Health Questionnaire-28 (GHQ-28) scores of Zen trainees in Japanese monasteries. Design: This was a single-center questionnaire-based study. Settings/location: The study was conducted in Rinzai Zen monasteries. Subject interventions: Anonymous and confidential surveys containing the SF-36 and GHQ-28 were distributed by mail, and 256 questionnaires were collected from Rinzai Zen monasteries. Outcome measures: One hundred ninety-eight complete questionnaires were collected and the participants were divided according to their training length: group I (<1 year), group II (1?3 years), and group III (≥3 years). One-way analysis of variance and Tukey test for multiple comparison were conducted on normally distributed data, and the Kruskal-Wallis test was performed on non-normally distributed data. Results: The SF-36 seven subscale scores (physical functioning, role-physical, body pain, general health, vitality, role-emotional, and mental health) of the longer-length training group were significantly higher compared to other groups. The SF-36 MCS (mental component summary) score among the groups were significantly different, and the scores of group III were significantly higher compared to the scores of group I. Furthermore, the GHQ-28 total and subscales (somatization, anxiety, social dysfunction, and depression) scores of longer-length training were significantly lower (better). Conclusions: These findings suggest that Zen professional training, including inward-attention practices, improves the QOL and general mental health of trainees, even in a tough and distressing environment. However, detailed qualitative and longitudinal studies are required to fully assess these effects.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140187/1/acm.2013.0209.pd

チュウゴク ノ タイトウ ト インドシナ サンゴク

大阪大學中國文化論壇 討論文件Discussion Papers in Contemporary China Studies, Osaka University Forum on Chin

Synthesis of 3a-(indol-3-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole core of leptosins D-F based on nucleophilic substitution reaction on indole nucleus

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部A simple and convenient synthetic methodology for 3a-(indol-3-yl)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, the core structure of leptosins D-F is developed by applying nucleophilic substitution reaction of 1- hydroxytryptamines