On the continuity of the magnetizing current density in 3-D magnetic field analysis with edge element

The effects of the continuity of the magnetizing current density on the convergence of the incomplete Cholesky conjugate gradient method and the accuracy of the calculated flux densities are investigated by imposing different continuity conditions for both nodal and edge elements. It is shown that the continuity condition should be imposed precisely in the case of edge elements </p

Practical analysis of 3-D dynamic nonlinear magnetic field using time-periodic finite element method

A practical 3-D finite element method using edge elements for analyzing stationary nonlinear magnetic fields with eddy currents in electric apparatus, in which the flux interlinking the voltage winding is given, has been proposed. The method is applied to the analysis of magnetic fields in the Epstein frame </p

Rapid estimation of direct economic losses caused by significant earthquakes: An evidence-based model and its applications

This paper presents a rapid or real-time estimation method of the economic value of direct stock damages caused by significant earthquakes in Japan. The result will contribute to both the government and private sectors’ early decision-making, particularly for provisional budget allocation. First, we developed a simple but evidence-based model for estimating stock losses explained by a representative earthquake hazard factor and an exposure factor, i.e., seismic intensity and existing stock of physical assets. The key characteristic of our estimation model is that the dependent variable is the prefectural damage amount. Still, the explanatory variables come from municipal sources: we overcome this data availability problem through our estimation process. Second, we carefully checked the model’s specification, estimation, and performance to be soundly applied to a real-time assessment of future earthquake events. We also explain the automated measuring of the prefectural direct loss value and its distribution to every 250 m mesh. Finally, we show two examples of the application of our model; one is the case of the 2018 Northern Osaka Earthquake, and the other is the anticipated Tokyo inland earthquake

Improvement of convergence characteristic of ICCG method for the A-&#966; method using edge elements

The effect of the scalar potential &#966; in the A-&#966; method on the convergence characteristic of the incomplete Cholesky conjugate gradient (ICCG) method using the edge element is investigated. Several 3-D eddy current models are analyzed both by taking into account &#966; and neglecting &#966; to compare the convergence characteristics. It is illustrated that the CPU time using &#966; is less than ½ of that neglecting &#966;, and there are some models in which the use of &#966; enables us to obtain convergent solutions </p

Extension of the Coherence Time by Generating MW Dressed States in a Single NV Centre in Diamond

Nitrogen-vacancy (NV) centres in diamond hold promise in quantum sensing applications. A major interest in them is an enhancement of their sensitivity by the extension of the coherence time ($T_2$). In this report, we experimentally generated more than four dressed states in a single NV centre in diamond based on Autler-Townes splitting (ATS). We also observed the extension of the coherence time to $T_2 \sim$ 1.5 ms which is more than two orders of magnitude longer than that of the undressed states. As an example of a quantum application using these results we propose a protocol of quantum sensing, which shows more than an order of magnitude enhancement in the sensitivity.Comment: 8 pages, 9 figure

Practical analysis of 3D dynamic nonlinear magnetic field using time-periodic finite element method

Abstract -A practical 3-D finite element method using edge elements for analyzing stationary nonlinear magnetic fields with eddy currents in electric apparatus, in which the flux interlinking the voltage winding is given, has been proposed. The method is applied to the analysis of magnetic fields in the Epstein frame

Erythropoietin Receptor Signaling Mitigates Renal Dysfunction-Associated Heart Failure by Mechanisms Unrelated to Relief of Anemia

ObjectivesWe examined the effect of asialoerythropoietin (asialoEPO), a nonerythrogenic derivative of erythropoietin (EPO), on renal dysfunction-associated heart failure.BackgroundAlthough EPO is known to exert beneficial effects on cardiac function, the clinical benefits in patients with chronic kidney disease are controversial. It remains to be addressed whether previously reported outcomes were the result of relief of the anemia, adverse effects of EPO, or direct cardiovascular effects.MethodsMice underwent 5/6 nephrectomy to cause renal dysfunction. Eight weeks later, when renal dysfunction was established, anemia and cardiac dysfunction and remodeling were apparent. Mice were then assigned to receive saline (control), recombinant human erythropoietin (rhEPO) at 5,000 IU (714 pmol)/kg, or asialoEPO at 714 pmol/kg, twice/week for 4 weeks.ResultsAlthough only rhEPO relieved the nephrectomy-induced anemia, both rhEPO and asialoEPO significantly and similarly mitigated left ventricular dilation and dysfunction. The hearts of rhEPO- or asialoEPO-treated mice showed less hypertrophy, reflecting decreases in cardiomyocyte hypertrophy and degenerative subcellular changes, as well as significant attenuation of fibrosis, leukocyte infiltration, and oxidative deoxyribonucleic acid damage. These phenotypes were accompanied by restored expression of GATA-4, sarcomeric proteins, and vascular endothelial growth factor and decreased inflammatory cytokines and lipid peroxidation. Finally, myocardial activation was observed of extracellular signal-regulated protein kinase and signal transducer and activator of transcription pathways in the treated mice.ConclusionsEPO receptor signaling exerts direct cardioprotection in an animal model of renal dysfunction-associated heart failure, probably by mitigating degenerative, pro-fibrosis, inflammatory, and oxidative processes but not through relief of anemia

Prompt Resolution of Hypoglycemia by Hepatic Transarterial Embolization for Malignant Insulinoma with Multiple Liver Metastases

A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and serum tumor markers. Fine needle aspiration revealed Grade 3 small-cell type primary pancreatic neuroendocrine carcinoma. Consequently, the diagnosis of malignant insulinoma was made. Transarterial embolization (TAE) for hepatic metastases resulted in the reduction of tumor volume and prompt resolution of hypoglycemic attacks, whereas diazoxide and systemic chemotherapy had been ineffective for controlling blood glucose levels, and octreotide was unavailable due to the allergic effect. This case report highlights the potential usefulness of TAE for malignant insulinomas in the management of hypoglycemia

The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial

Background Daikenchuto (TJ-100), a traditional Japanese herbal medicine, is widely used in Japan. Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known. The purpose of this prospective randomized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients. Methods Forty patients for whom subtotal esophageal resection for esophageal cancer was planned at our institute from March 2011 to August 2013 were enrolled and divided into two groups at the point of determination of the operation schedule after informed consent was obtained: a TJ-100 (15 g/day)-treated group (n = 20) and a control group (n = 20). The primary efficacy end-points were maintenance of the nutrition condition and the recovery of gastrointestinal function. The secondary efficacy end-points were the serum C-reactive protein (CRP) level and adrenomedullin level during the postoperative course, the incidence of postoperative complications, and the length of hospital stay after surgery. Results We examined 39 patients because one patient in the TJ-100 group was judged as having unresectable cancer after surgery. The mean age of the TJ-100 group patients was significantly older than that of the control group patients.The rate of body weight decrease at postoperative day 21 was significantly suppressed in the TJ-100 group (3.6% vs. the control group: 7.0%, p = 0.014), but the serum albumin level was not significantly different between the groups. The recovery of gastrointestinal function regarding flatus, defecation, and oral intake showed no significant between-group differences, but postoperative bowel symptoms tended to be rare in the TJ-100 group. There was no significant between-group difference in the length of hospital stay after surgery. The serum CRP level at postoperative day 3 was 4.9 mg/dl in the TJ-100 group and 6.9 mg/dl in the control group, showing a tendency of a suppressed serum CRP level in the TJ-100 group (p = 0.126). The rate of increase in adrenomedullin tended to be high postoperatively, but there was no significant difference between the two groups. Conclusions TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss, and it might suppress the excess inflammatory reaction related to surgery