Design and fuel management of PWR cores to optimize the once-through fuel cycle

Originally presented as the first author's thesis, (Sc.D.) in the M.I.T. Dept. of Nuclear Engineering, 1978.The once-through fuel cycle has been analyzed to see if there are substantial prospects for improved uranium ore utilization in current light water reactors, with a specific focus on pressurized water reactors. The types of changes which have been examined are: (1) re-optimization of fuel pin diameter and lattice pitch, (2) Axial power shaping by enrichment gradation in fresh fuel, (3) Use of 6-batch cores with semi-annual refueling, (4) Use of 6-batch cores with annual refueling, hence greater extended (.doubled) burnup, (5) Use of radial reflector assemblies, (6) Use of internally heterogeneous cores (simple seed/blanket configurations), (7) Use of power/temperature coastdown at the end of life to extend burnup, (8) Use of metal or diluted oxide fuel, (9) Use of thorium, and (10) Use of isotopically separated low a cladding material. a State-of-the-art LWR computational methods, LEOPARD/PDQ-7/FLARE-G, were used to investigate these modifications. The most effective way found to improve uranium ore utilization is to increase the discharge burnup. Ore savings on the order of 20% can be realized if greatly extended burnup (- double that of current practice) is combined with an increase in the number of batches in the core from 3 to 6. The major conclusion of this study is that cumulative reductions in ore usage of on the order of 30% are fore- seeable relative to a current PWR operating on the once-through fuel cycle, which is comparable to that expected for the same cores operated in the recycle mode.DOE Contract no. EN-77-S-02-4570

Design and fuel management of PWR cores to optimize the once-through fuel cycle

DOE Contract no. EN-77-S-02-4570Originally presented as the first author's thesis, (Sc. D.)--in the M.I.T. Dept. of Nuclear Engineering, 1978Includes bibliographical references (pages 238-241

Synergistic and Offset Effects of Fungal Species Combinations on Plant Performance

「1+1=2」じゃない共生の世界 --2種の菌が植物にもたらす相乗効果と相殺効果--. 京都大学プレスリリース. 2021-09-17.In natural and agricultural ecosystems, survival and growth of plants depend substantially on residing microbes in the endosphere and rhizosphere. Although numerous studies have reported the presence of plant-growth promoting bacteria and fungi in below-ground biomes, it remains a major challenge to understand how sets of microbial species positively or negatively affect plants’ performance. By conducting a series of single- and dual-inoculation experiments of 13 plant-associated fungi targeting a Brassicaceae plant species (Brassica rapa var. perviridis), we here systematically evaluated how microbial effects on plants depend on presence/absence of co-occurring microbes. The comparison of single- and dual-inoculation experiments showed that combinations of the fungal isolates with the highest plant-growth promoting effects in single inoculations did not have highly positive impacts on plant performance traits (e.g., shoot dry weight). In contrast, pairs of fungi with small/moderate contributions to plant growth in single-inoculation contexts showed the greatest effects on plants among the 78 fungal pairs examined. These results on the offset and synergistic effects of pairs of microbes suggest that inoculation experiments of single microbial species/isolates can result in the overestimation or underestimation of microbial functions in multi-species contexts. Because keeping single-microbe systems under outdoor conditions is impractical, designing sets of microbes that can maximize performance of crop plants is an important step for the use of microbial functions in sustainable agriculture

Introduction of Low-Carbon Community Energy Systems by Combining Information Networks and Cogeneration-Type District Heating and Cooling Systems

Achievement of a low-carbon society is becoming extremely important. In this report, we introduce an example of carbon dioxide (CO2) emission reductions and energy savings, using a local energy-control system. Our research is focused on the town of Shinchi in the Fukushima Prefecture, Japan. Shinchi is pursuing initiatives to create a low-carbon, energy-efficient society and a disaster-resilient community. The National Institute for Environmental Studies provides academic support for the design and planning of low-carbon community energy systems by the local government of Shinchi, based on the Basic Cooperation Agreement. For the redevelopment of the Japan Railway (JR) Shinchi Station district that is being carried out, construction of a cogeneration-type district heating and cooling system is currently in progress. CO2 reductions of about 20% can be expected by introducing this community energy system. To support these initiatives, we have developed an information and communication technology (ICT) system that shares a wide range of local information to support energy conservation. By analyzing electricity consumption data from the ICT, we evaluated the pattern of residential power consumption and confirmed that the project supports energy-saving behavior within the community. Additionally, the community energy project in the JR Shinchi Station district enables adjustment of the supply and demand balance

Endosonography-Guided Pancreatic Duct Drainage for Chronic Pancreatitis: A Case Report and Review

A 50-year-old man was admitted to our department, complaining of epigastric pain and high fever. CT revealed a pseudocyst at the pancreatic head with upstream dilatation of the pancreatic duct (PD) and fluid collection surrounding the pancreas. Endosonography-guided PD drainage (ESPD) was performed because of unsuccessful ERCP. With a curved linear array echoendoscope, a 7.2 F catheter was placed in the PD. Laboratory data showed improvement in a few days and revealed disappearance of the fluid collection. Ten days after ESPD, a 7 F stent was placed in the PD via the puncture tract across the papilla of Vater followed by transpapillary replacement with a 10 F stent. CT showed a reduction in diameter of the PD and disappearance of the pseudocyst. ESPD is a feasible and useful procedure in selected patients with chronic pancreatitis showing stenosis of the main PD when transpapillary approach is impossible

Customized chemotherapy based on epidermal growth factor receptormutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial

BACKGROUND: Elderly patients are more vulnerable to toxicity from chemotherapy. Activating epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) are associated with enhanced response to EGFR tyrosine-kinase inhibitors. We studied patients with advanced NSCLC for whom treatment was customized based on EGFR mutation status. METHODS: We screened 57 chemotherapy-naïve patients with histologically or cytologically confirmed NSCLC, stage IIIB or IV, aged 70 years or older, and with an Eastern Cooperative Oncology Group performance status 0 or 1, for EGFR exon 19 codon 746–750 deletion and exon 21 L858R mutation. Twenty-two patients with EGFR mutations received gefitinib; 32 patients without mutations received vinorelbine or gemcitabine. The primary endpoint was the response rate. RESULTS: The response rate was 45.5% (95% confidence interval [CI]: 24.4%, 67.8%) in patients with EGFR mutations and 18.8% (95% CI: 7.2%, 36.4%) in patients without EGFR mutations. The median overall survival was 27.9 months (95%CI: 24.4 months, undeterminable months) in patients with EGFR mutations and 14.9 months (95%CI: 11.0 months, 22.4 months) in patients without EGFR mutations. In the gefitinib group, grade 3/4 hepatic dysfunction and dermatitis occurred in 23% and 5% of patients, respectively. In patients treated with vinorelbine or gemcitabine, the most common grade 3 or 4 adverse events were neutropenia (47%; four had febrile neutropenia), anemia (13%), and anorexia (9%). No treatment-related deaths occurred. CONCLUSIONS: Treatment customization based on EGFR mutation status deserves consideration, particularly for elderly patients who often cannot receive second-line chemotherapy due to poor organ function or comorbidities. TRIAL REGISTRATION: This trial is registered at University hospital Medical Information Network-clinical trial registration (http://www.umin.ac.jp/ctr/index/htm) with the registration identification number C000000436

A Case of Mucosal Cancer of the Stomach Treated by Endoscopic Submucosal Dissection after Which Nodal Metastasis Became Evident

An 82-year-old male was referred to our institution for evaluation and treatment of a protruding lesion in the stomach. Esophagogastroduodenoscopy (EGD) showed a small protruding lesion and a large superficial elevated lesion on the lesser curvature of the stomach (macroscopic type: 0-I and 0-IIa, resp.). CT and endoscopic ultrasonography (EUS) visualized a small round lymph node (LN) 11 mm in size near the lesser curvature, although submucosal invasion was not evident. These two lesions were resected en bloc by endoscopic submucosal dissection (ESD). Pathological examination of the resected specimen showed moderately differentiated tubular adenocarcinoma (tub2) and well-differentiated tubular adenocarcinoma (tub1), respectively, which were limited to the mucosal layer. Because lymphatic-vascular involvement was not detected by hematoxylin and eosin (HE) staining, additional gastrectomy was not performed. Two months after ESD, follow-up EUS and CT showed an enlarged LN. EUS-guided fine needle aspiration (EUS-FNA) for the LN revealed metastasis. Therefore, total gastrectomy with LN dissection was performed. His postoperative course was uneventful. After discharge, he has been followed up at the outpatient department without any sign of recurrence for 5 years. Histological reexamination of the ESD specimen using immunohistochemistry showed lymphatic invasion of cancer cells in the lamina propria of the 0-I lesion 13 mm in size

Newly Developed Fully Covered Metal Stent for Unresectable Malignant Biliary Stricture

We herein report two patients with unresectable malignant biliary stricture who underwent stenting with a newly developed fully-covered metal stent. In the first case of lower-middle bile duct cancer, a stent was placed through the stenosis. In the second case of middle bile duct stricture due to lymph node metastases from gallbladder cancer, a stent was placed in the bile duct across the stenosis. No procedure-related complications were observed. Unevenness of the outer surface and a low shortening ratio are expected to lessen the occurrence of complications characteristic of covered metal stents such as stent migration and bile duct kinking