1,001 research outputs found
Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after transplantation. With the median effect analysis of Chou and Kahan for quantitative drug interactions, substantial therapeutic synergism was demonstrated between FK506 and nontoxic doses of MĪZ (2.5, 5, and 10 mg/kg/day) or AZA (5, 30, and 45 mg/kg/day), which was particularly evident with the lowest dose MIZ (2.5 mg/kg/day). When FK506 was used in combination with MIZ or AZA but not with RS, the maximum effect (peak median graft survival) was enhanced significantly from 15 days (MIZ alone) to 26 days (P<0.05), and from 19 days (AZA alone) to 32 days (P<0.0l). In contrast, RS interacted with FK506 no more than additively. Although RS was the most powerful single antimetabolite, the best overall survival was obtained by combining AZA and FK506. The addition of FK506 did not significantly increase the percent mortality and LD50 of the antimetabolites. © 1994 by Williams and Wilkins
Bone marrow augmentation for heart, liver, and small bowel transplantation: Prolongation of graft survival and incidence of graft- versus-host disease
Small bowel transplantation in sensitized recipients: Comparison with heart, kidney, and liver grafts
Graft-versus-host disease in fully allogeneic small bowel transplantation: incidence of the disease and strain combinations.
Bosonic D-branes at finite temperature with an external field
Bosonic boundary states at finite temperature are constructed as solutions of
boundary conditions at for bosonic open strings with a constant gauge
field coupled to the boundary. The construction is done in the
framework of thermo field dynamics where a thermal Bogoliubov transformation
maps states and operators to finite temperature. Boundary states are given in
terms of states from the direct product space between the Fock space of the
closed string and another identical copy of it. By analogy with zero
temperature, the boundary states heve the interpretation of -brane at
finite temperature. The boundary conditions admit two different solutions. The
entropy of the closed string in a -brane state is computed and analysed. It
is interpreted as the entropy of the -brane at finite temperature.Comment: 21 pages, Latex, revised version with minor corrections and
references added, to be published in Phys. Rev.
The CWKB Method of Particle Production in Periodic Potential
In this work we study the particle production in time dependent periodic
potential using the method of complex time WKB (CWKB) approximation. In the
inflationary cosmology at the end of inflationary stage, the potential becomes
time dependent as well as periodic. Reheating occurs due to particle production
by the oscillating inflaton field. Using CWKB we obtain almost identical
results on catastrophic particle production as obtained by others.Comment: 17 pages, latex, 2 figure
Hidden variable interpretation of spontaneous localization theory
The spontaneous localization theory of Ghirardi, Rimini, and Weber (GRW) is a
theory in which wavepacket reduction is treated as a genuine physical process.
Here it is shown that the mathematical formalism of GRW can be given an
interpretation in terms of an evolving distribution of particles on
configuration space similar to Bohmian mechanics (BM). The GRW wavefunction
acts as a pilot wave for the set of particles. In addition, a continuous stream
of noisy information concerning the precise whereabouts of the particles must
be specified. Nonlinear filtering techniques are used to determine the dynamics
of the distribution of particles conditional on this noisy information and
consistency with the GRW wavefunction dynamics is demonstrated. Viewing this
development as a hybrid BM-GRW theory, it is argued that, besides helping to
clarify the relationship between the GRW theory and BM, its merits make it
worth considering in its own right.Comment: 13 page
- …