666 research outputs found
Spin-1/2 geometric phase driven by decohering quantum fields
We calculate the geometric phase of a spin-1/2 system driven by a one and two
mode quantum field subject to decoherence. Using the quantum jump approach, we
show that the corrections to the phase in the no-jump trajectory are different
when considering an adiabatic and non-adiabatic evolution. We discuss the
implications of our results from both the fundamental as well as quantum
computational perspective.Comment: 4 page
Solar irradiance dictates settlement timing and intensity of marine mussels
11 páginas, 4 figuras, 2 tablas.-- This work is licensed under a Creative Commons Attribution 4.0 International LicenseIdentifying the environmental factors driving larval settlement processes is crucial to understand the population dynamics of marine invertebrates. This work aims to go a step ahead and predict larval presence and intensity. For this purpose we consider the influence of solar irradiance, wind regime and continental runoff on the settlement processes. For the first time, we conducted a 5-years weekly monitoring of Mytilus galloprovincialis settlement on artificial suspended substrates, which allowed us to search for interannual variability in the settlement patterns. Comparison between the seasonal pattern of larval settlement and solar irradiance, as well as the well-known effect of solar irradiance on water temperature and food availability, suggest that solar irradiance indirectly influences the settlement process, and support the use of this meteorological variable to predict settlement occurrence. Our results show that solar irradiance allows predicting the beginning and end of the settlement cycle a month in advance: Particularly we have observed that solar irradiance during late winter indirectly drives the timing and intensity of the settlement onset, Finally, a functional generalise additive model, which considers the influence of solar irradiance and continental runoff on the settlement process, provides an accurate prediction of settlement intensity a fortnight in advanceThis study was funded by PROINSA-CSIC contract-project (CSIC0704101100001), CSIC- PIE project (CSIC 201540E107) and EU H2020 project ClimeFish (EU 677039).Peer reviewe
Eating Disorders as New Forms of Addiction
Eating disorders (ED) seem to share many characteristics with substance-related disorders (SRD). As very often the two conditions run together, it has been proposed that eating dysfunctions could be understood as behavioral forms of addiction. This has lead to the concept of “food addiction,” a proposed new form of addiction. This chapter reviews recent research focusing on the relationship between ED and SRD. Three specific areas are addressed: (a) animal models that suggest the association between substance dependence and compulsive overeating; (b) epidemiological studies that confirm the comorbidity between ED and SRD; and (c) neuroimaging studies that reveal the existence of modifications in the reward circuits following binge eating and other eating dysfunctions. The data from the different studies can be integrated into a model based on the consideration of “food addiction” as a specific form of behavioral addiction that could be applied at least to a group of patients suffering from eating disorders
Consequences of increased longevity for wealth, fertility, and population growth
We present, solve and numerically simulate a simple model that describes the
consequences of increased longevity on fertility rates, population growth and
the distribution of wealth in developed societies. We look at the consequences
of the repeated use of life extension techniques and show that they represent a
novel commodity whose introduction will profoundly influence key aspects of
economy and society in general. In particular, we uncover two phases within our
simplified model, labeled as 'mortal' and 'immortal'. Within the life extension
scenario it is possible to have sustainable economic growth in a population of
stable size, as a result of dynamical equilibrium between the two phases.Comment: 13 pages, 5 figures, uses elsart.cl
Geometric phase in open systems
We calculate the geometric phase associated to the evolution of a system
subjected to decoherence through a quantum-jump approach. The method is general
and can be applied to many different physical systems. As examples, two main
source of decoherence are considered: dephasing and spontaneous decay. We show
that the geometric phase is completely insensitive to the former, i.e. it is
independent of the number of jumps determined by the dephasing operator.Comment: 4 pages, 2 figures, RevTe
Improved Performance of an Epoxy Matrix as a Result of Combining Graphene Oxide and Reduced Graphene
We present an easy and effective way to improve the mechanical properties of an epoxy matrix by reinforcing it with a combination of graphene oxide (GO) and reduced graphene oxide (RGO). These nanocomposites were prepared with different load of nanofillers: 0.1, 0.4, 0.7, 1.0 wt% and a neat epoxy. Ratios of graphene oxide and reduced graphene (GO : RGO) employed were: 0 : 1, 0.25 : 0.75, 0.5 : 0.5, 0.75 : 0.25, and 1 : 0. Results show that with only 0.4 wt% and a ratio 0.2 : 0.75 of GO : RGO, tensile strength and tensile toughness are 52% and 152% higher than neat epoxy while modulus of elasticity was improved ~20%. The obtained results suggest that it is possible achieve advantageous properties by combining graphene in oxidized and reduced conditions as it shows a synergic effect by the presence of both nanofillers
Modeling the impact of climate change on mussel aquaculture in a coastal upwelling system: A critical assessment
Forecasting of climate change impacts on marine aquaculture production has become a major research task, which requires taking into account the biases and uncertainties arising from ocean climate models in coastal areas, as well as considering culture management strategies. Focusing on the suspended mussel culture in the NW Iberian coastal upwelling system, we simulated current and future mussel growth by means of a multistructural net production Dynamic Energy Budget (DEB) model. We considered two scenarios and three ocean climate models to account for climate uncertainty, and applied a bias correction to the climate models in coastal areas. Our results show that the predicted impact of climate change on mussel growth is low compared with the role of the seeding time. However, the response of mussels varied across climate models, ranging from a minor growth decline to a moderate growth increase. Therefore, this work confirms that an accurate forecasting of climate change impacts on shellfish aquaculture should take into account the variability linked to both management strategies and climate uncertainty
The technique of underpinning with micropiles in conserving a compacted earth wall using "tapial-technic"
Durante el proceso de ejecución de un aparcamiento público subterráneo en la ciudad de Granada (España) se descubrió una obra de ingeniería hidráulica periurbana de 55 m de longitud con tres tajamares (declarado BIC en el 2007) ligado a la margen izquierda del río Genil. Se detectaron tres fases constructivas, muro monolítico (s. XI), tapia real (s. XII-XIII) y una reparación posterior (s. XIX) a base de cajones de mampostería con machones e hiladas de ladrillo. Para la conservación de este elemento en su posición original se ejecutaron: micropilotes verticales en su perímetro; otros horizontales en su base; viga riostra de encepado y bulones con barra Gewi pasantes a la viga de arriostramiento. Durante la excavación, se ejecutó un entramado de perfiles metálicos laminados «L» soldados entre sí y a los micropilotes. El elemento está totalmente integrado en la obra subterránea y en el entorno del Paseo del Violón.In this paper, the discovery of a peri-urban work of hydraulic engineering is presented. A wall-dike was found during the excavation for an underground public parking on the left bank of the Genil River in Granada city (Spain). Those consist in a compacted earth wall (using “Tapial-technic”) of 55 m length with three cutwaters. Three different construction methodologies were detected in the wall-dike: monolithic-wall (s. XI), royal wall (s. XII-XIII) and contemporary reparation (s. XIX). These elements were conserved in the original position with the help of the micropiles technique. The consolidation stages were as follows: vertical micropiles in its perimeter; horizontals micropiles in the base of the wall; brace beam and thought bolts with Gewi rod. After the digging, also, laminated metal sections with an “L” were welded together and to vertical micropiles. That element is fully integrated with both underground construction and its environment, “Paseo del Violón”.Queremos agradecer la colaboración de las empresas Ges-pad-Al-Andalus.S.L. y SITE S.A
Solid phase extraction of ocean dissolved organic matter with PPL cartridges: efficiency and selectivity
Our current knowledge of the chemical composition of ocean dissolved organic matter (DOM) is limited, mainly because of its extreme molecular diversity, low concentration of individual compounds and the elevated ionic strength of ocean waters. As a result, many analytical methods require a previous extraction step. The efficiency and selectivity of the extraction method defines the representativeness of the extracted DOM fraction. Nowadays, the most widespread procedure for concentrating DOM is solid phase extraction (SPE) using styrene divinyl benzene polymer cartridges (PPL). Here, we investigate the effect of SPE-PPL on DOM elemental and optical properties to assess the efficiency and selectivity of this extraction method on water samples from the main intermediate and deep water masses of Arctic, Mediterranean and Antarctic origin present in the Cape Vert Frontal Zone (CVFZ, NW Africa). Furthermore, North and South Atlantic Central waters converge in this area and coastal DOM is injected by the giant upwelling filament of Cape Blanc. On one side, the colored fraction of DOM (CDOM) presented extraction efficiencies comparable to that of the bulk dissolved organic carbon (DOC), but decreased significantly with increasing wavelength, suggesting an affinity of PPL cartridges for low molecular weight organic compounds. While the protein-like fluorescent fraction of DOM (FDOM) was also extracted with the same efficiency than DOC, the extraction efficiency of the humic-like fraction was comparatively much higher. On the other side, dissolved organic nitrogen (DON) extraction efficiencies were about half that of DOC. These contrasting extraction efficiencies of the different DOM pools indicated that the extracts were enriched in N-poor, low molecular weight and recalcitrant DOM, therefore showing less variability than the corresponding bulk DOM. Furthermore, DOC, DON, CDOM and FDOM extracted were not homogeneous through the water column but displayed certain significant differences among water masses in both efficiency and selectivity
Longitudinal outcomes of obeticholic acid therapy in ursodiol-nonresponsive primary biliary cholangitis: Stratifying the impact of add-on fibrates in real-world practice
Background
Suboptimal response to ursodeoxycholic acid occurs in 40% of primary biliary cholangitis (PBC) patients, affecting survival. Achieving a deep response (normalisation of alkaline phosphatase [ALP] and bilirubin ≤0.6 upper limit of normal) improves survival. Yet, the long-term effectiveness of second-line treatments remains uncertain.
Aims
To evaluate the long-term effectiveness of obeticholic acid (OCA) ± fibrates. Focusing on biochemical response (ALP ≤1.67 times the upper limit of normal, with a decrease of at least 15% from baseline and normal bilirubin levels), normalisation of ALP, deep response and biochemical remission (deep response plus aminotransferase normalisation).
Methods
We conducted a longitudinal, observational, multicentre study involving ursodeoxyccholic acid non-responsive PBC patients (Paris-II criteria) from Spain and Portugal who received OCA ± fibrates.
Results
Of 255 patients, median follow-up was 35.1 months (IQR: 20.2–53). The biochemical response in the whole cohort was 47.2%, 61.4% and 68.6% at 12, 24 and 36 months. GLOBE-PBC and 5-year UK-PBC scores improved (p < 0.001). Triple therapy (ursodeoxycholic acid plus OCA plus fibrates) had significantly higher response rates than dual therapy (p = 0.001), including ALP normalisation, deep response and biochemical remission (p < 0.001). In multivariate analysis, triple therapy remained independently associated with biochemical response (p = 0.024), alkaline phosphatase normalisation, deep response and biochemical remission (p < 0.001). Adverse effects occurred in 41.2% of cases, leading to 18.8% discontinuing OCA. Out of 55 patients with cirrhosis, 12 developed decompensation. All with baseline portal hypertension.
Conclusion
Triple therapy was superior in achieving therapeutic goals in UDCA-nonresponsive PBC. Decompensation was linked to pre-existing portal hypertension
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