56 research outputs found
Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1
) mice. The present study examines the effects of TSC2 ablation on insulin secretion from pancreatic beta cells. mice and TSC2 knockdown insulin 1 (INS-1) insulinoma cells treated with small interfering ribonucleic acid were used to investigate insulin secretion, ATP content and the expression of mitochondrial genes. mice exhibit hyperinsulinemia due to an increase in the number of mitochondria as well as enlargement of individual beta cells via activation of mTORC1.Activation of mTORC1 by TSC2 ablation increases mitochondrial biogenesis and enhances insulin secretion from pancreatic beta cells
Metallation of Aliphatic Carbon Atoms. IV. Syntheses and Characterization of the Cyclopalladated Complexes of 2- t
Synthesis and Characterization of Six-Membered Cyclometallated Complexes of 2-Bezylpyridine with Rhodium(III)
Efficient Functionalization of Aromatic C-H Bonds Catalyzed by Gold(III) under Mild and Solvent-Free Conditions
Highly Efficient Addition of Activated Methylene Compounds to Alkenes Catalyzed by Gold and Silver
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