XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk

<p>Abstract</p> <p>Background</p> <p>Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of hepatocellular carcinoma (HCC) related to the exposure of aflatoxin B1 (AFB1). In this study, we have focused on the polymorphisms of xeroderma pigmentosum complementation group D (XPD) codon 312 and 751 (namely Asp312Asn and Lys751Gln), involved in nucleotide excision repair.</p> <p>Methods</p> <p>We conducted a case-control study including 618 HCC cases and 712 controls to evaluate the associations between these two polymorphisms and HCC risk for Guangxi population by means of TaqMan-PCR and PCR-RFLP analysis.</p> <p>Results</p> <p>We found that individuals featuring the XPD genotypes with codon 751 Gln alleles (namely XPD-LG or XPD-GG) were related to an elevated risk of HCC compared to those with the homozygote of XPD codon 751 Lys alleles [namely XPD-LL, adjusted odds ratios (ORs) were 1.75 and 2.47; 95% confidence interval (CIs) were 1.30-2.37 and 1.62-3.76, respectively]. A gender-specific role was evident that showed an higher risk for women (adjusted OR was 8.58 for XPD-GG) than for men (adjusted OR = 2.90 for XPD-GG). Interestingly, the interactive effects of this polymorphism and AFB1-exposure information showed the codon 751 Gln alleles increase the risk of HCC for individuals facing longer exposure years (<it>P</it>_interaction= 0.011, OR = 0.85). For example, long-exposure-years (> 48 years) individuals who carried XDP-GG had an adjusted OR of 470.25, whereas long-exposure-years people with XDP-LL were at lower risk (adjusted OR = 149.12). However, we did not find that XPD codon 312 polymorphism was significantly associated with HCC risk.</p> <p>Conclusion</p> <p>These findings suggest that XPD Lys751Gln polymorphism is an important modulator of AFB1 related-HCC development in Guangxi population.</p

Search for the decay J/ψ→γ+invisibleJ/\psi\to\gamma + \rm {invisible}

We search for $J/\psi$ radiative decays into a weakly interacting neutral particle, namely an invisible particle, using the $J/\psi$ produced through the process $\psi(3686)\to\pi^+\pi^-J/\psi$ in a data sample of $(448.1\pm2.9)\times 10^6$ $\psi(3686)$ decays collected by the BESIII detector at BEPCII. No significant signal is observed. Using a modified frequentist method, upper limits on the branching fractions are set under different assumptions of invisible particle masses up to 1.2 $\mathrm{\ Ge\kern -0.1em V}/c^2$. The upper limit corresponding to an invisible particle with zero mass is 7.0$\times 10^{-7}$ at the 90\% confidence level

Search for the reaction e+e−→χcJπ+π− and a charmoniumlike structure decaying to χcJπ± between 4.18 and 4.60 GeV

We search for the process e+e-→χcJπ+π- (J=0, 1, 2) and for a charged charmoniumlike state in the χcJπ± subsystem. The search uses datasets collected with the BESIII detector at the BEPCII storage ring at center-of-mass energies between 4.18 GeV and 4.60 GeV. No significant χcJπ+π- signals are observed at any center-of-mass energy, and thus upper limits are provided which also serve as limits for a possible charmoniumlike structure in the invariant χcJπ± mass

Observation of a structure in e+e−→ϕη′e^+e^- \to \phi \eta^{\prime} at s\sqrt{s} from 2.05 to 3.08 GeV

The process $e^{+}e^{-} \to \phi \eta^{\prime}$ has been studied for the first time in detail using data sample collected with the BESIII detector at the BEPCII collider at center of mass energies from 2.05 to 3.08 GeV. A resonance with quantum numbers $J^{PC}=1^{--}$ is observed with mass $M$ = (2177.5 $\pm$ 4.8 (stat) $\pm$ 19.5 (syst)) MeV/${ \it{c}^{\mathrm{2}}}$ and width $\Gamma$ = (149.0 $\pm$ 15.6 (stat) $\pm$ 8.9 (syst)) MeV with a statistical significance larger than 10$\sigma$. The observed structure could be identified with the $\phi(2170)$, then the ratio of partial width between the $\phi \eta^{\prime}$ by BESIII and $\phi \eta$ by BABAR is ($\mathcal{B}^{R}_{\phi \eta}\Gamma^{R}_{ee})/{(\mathcal{B}^{R}_{\phi \eta^{\prime}}\Gamma^{R}_{ee})}$ = 0.23 $\pm$ 0.10 (stat) $\pm$ 0.18 (syst), which is smaller than the prediction of the $s\bar{s}g$ hybrid models by several orders of magnitude

Measurements of the absolute branching fractions of D0(+)→KKˉππD^{0(+)}\to K\bar K\pi\pi decays

Based on 2.93~fb$^{-1}$ $e^+e^-$ collision data taken at center-of-mass energy of 3.773 GeV by the BESIII detector, we report the measurements of the absolute branching fractions of $D^0\to K^+K^-\pi^0\pi^0$, $D^0\to K^0_SK^0_S\pi^+\pi^-$, $D^0\to K^0_SK^-\pi^+\pi^0$, $D^0\to K^0_SK^+\pi^-\pi^0$, $D^+\to K^+K^-\pi^+\pi^0$, $D^+\to K^0_SK^+\pi^0\pi^0$, $D^+\to K^0_SK^-\pi^+\pi^+$, $D^+\to K^0_SK^+\pi^+\pi^-$, and $D^+\to K^0_SK^0_S\pi^+\pi^0$. The decays $D^0\to K^+K^-\pi^0\pi^0$, $D^0\to K^0_SK^-\pi^+\pi^0$, $D^0\to K^0_SK^+\pi^-\pi^0$, $D^+\to K^0_SK^0_S\pi^+\pi^0$, and $D^+\to K^0_SK^+\pi^0\pi^0$ are observed for the first time. The branching fractions of the decays $D^0\to K^0_SK^0_S\pi^+\pi^-$, $D^+\to K^+K^-\pi^+\pi^0$, $D^+\to K^0_SK^-\pi^+\pi^+$, and $D^+\to K^0_SK^+\pi^+\pi^-$ are measured with improved precision compared to the world-average values.Comment: 11 pages, 5 figure