RLTF: Reinforcement Learning from Unit Test Feedback

The goal of program synthesis, or code generation, is to generate executable code based on given descriptions. Recently, there has been an increasing number of studies employing reinforcement learning (RL) to improve the performance of large language models (LLMs) for code. However, these RL methods have only used offline frameworks, limiting their exploration of new sample spaces. Additionally, current approaches that utilize unit test signals are rather simple, not accounting for specific error locations within the code. To address these issues, we proposed RLTF, i.e., Reinforcement Learning from Unit Test Feedback, a novel online RL framework with unit test feedback of multi-granularity for refining code LLMs. Our approach generates data in real-time during training and simultaneously utilizes fine-grained feedback signals to guide the model towards producing higher-quality code. Extensive experiments show that RLTF achieves state-of-the-art performance on the APPS and the MBPP benchmarks. Our code can be found at: https://github.com/Zyq-scut/RLTF

Nadir CA-125 level as prognosis indicator of high-grade serous ovarian cancer

PURPOSE: The capacity of nadir CA-125 levels to predict the prognosis of epithelial ovarian cancer remains controversial. This study aimed to explore whether the nadir CA-125 serum levels could predict the durations of overall survival (OS) and progression free survival (PFS) in patients with high-grade serous ovarian cancer (HG-SOC) from the USA and PRC. MATERIALS AND METHODS: A total of 616 HG-SOC patients from the MD Anderson Cancer Center (MDACC, USA) between 1990 and 2011 were retrospectively analyzed. The results of 262 cases from the Jiangsu Institute of Cancer Research (JICR, PRC) between 1992 and 2011 were used to validate the MDACC data. The CA-125 immunohistochemistry assay was performed on 280 tissue specimens. The Cox proportional hazards model and the log-rank test were used to assess the associations between the clinicopathological characteristics and duration of survival. RESULTS: The nadir CA-125 level was an independent predictor of OS and PFS (p < 0.01 for both) in the MDACC patients. Lower nadir CA-125 levels (≤10 U/mL) were associated with longer OS and PFS (median: 61.2 and 16.8 months with 95% CI: 52.0–72.4 and 14.0–19.6 months, respectively) than their counterparts with shorter OS and PFS (median: 49.2 and 10.5 months with 95% CI: 41.7–56.7 and 6.9–14.1 months, respectively). The nadir CA-125 levels in JICR patients were similarly independent when predicting the OS and PFS (p < 0.01 for both). Nadir CA-125 levels less than or equal to 10 U/mL were associated with longer OS and PFS (median: 59.9 and 15.5 months with 95% CI: 49.7–70.1 and 10.6–20.4 months, respectively), as compared with those more than 10 U/mL (median: 42.0 and 9.0 months with 95% CI: 34.4–49.7 and 6.6–11.2 months, respectively). Baseline serum CA-125 levels, but not the CA-125 expression in tissues, were associated with the OS and PFS of HG-SOC patients in the MDACC and JICR groups. However, these values were not independent. Nadir CA-125 levels were not associated with the tumor burden based on second-look surgery (p = 0.09). Patients who achieved a pathologic complete response had longer OS and PFS (median: 73.7 and 20.7 months with 95% CI: 63.7–83.7 and 9.5–31.9 months, respectively) than those with residual tumors (median: 34.6 and 10.6 months with 95% CI: 6.9–62.3 and 4.9–16.3 months, respectively). CONCLUSIONS: The nadir CA-125 level was an independent predictor of OS and PFS in HG-SOC patients. Further prospective studies are required to clinically optimize the chances for a complete clinical response of HG-SOC cases with higher CA-125 levels (>10 U/mL) at the end of primary treatment

Ultrahigh-Frequency Surface Acoustic Wave Sensors with Giant Mass-Loading Effects on Electrodes

Surface acoustic wave (SAW) devices are widely used for physical, chemical, and biological sensing applications, and their sensing mechanisms are generally based on frequency changes due to mass-loading effects at the acoustic wave propagation area between two interdigitated transducers (IDTs). In this paper, a new sensing mechanism has been proposed based on a significantly enhanced mass-loading effect generated directly on Au IDT electrodes, which enables significantly enhanced sensitivity, compared with that of conventional SAW devices. The fabricated ultrahigh-frequency SAW devices show a significant mass-loading effect on the electrodes. When the Au-electrode thickness increased from 12 to 25 nm, the Rayleigh mode resonant frequency decreased from 7.77 to 5.93 GHz, while that of the higher longitudinal leaky SAW decreased from 11.87 to 9.83 GHz. The corresponding mass sensitivity of 7309 MHz·mm2·μg–1 (Rayleigh mode) is ∼8.9 × 1011 times larger than that of a conventional quartz crystal balance (with a frequency of 5 MHz) and ∼1000 times higher than that of conventional SAW devices (with a frequency of 978 MHz). Trinitrotoluene concentration as low as 4.4 × 10–9 M (mol·L–1) can be detected using the fabricated SAW sensor, proving its giant mass-loading effect and ultrahigh sensitivity

30 GHz surface acoustic wave transducers with extremely high mass sensitivity

A nano-patterning process is reported in this work, which can achieve surface acoustic wave (SAW) devices with an extremely high frequency and a super-high mass sensitivity. An integrated lift-off process with ion beam milling is used to minimize the short-circuiting problem and improve the quality of nanoscale interdigital transducers (IDTs). A specifically designed proximity-effect-correction algorithm is applied to mitigate the proximity effect occurring in the electron-beam lithography process. The IDTs with a period of 160 nm and a finger width of 35 nm are achieved, enabling a frequency of ∼30 GHz on lithium niobate based SAW devices. Both centrosymmetric type and axisymmetric type IDT structures are fabricated, and the results show that the centrosymmetric type tends to excite lower-order Rayleigh waves and the axisymmetric type tends to excite higher-order wave modes. A mass sensitivity of ∼388.2 MHz × mm2/μg is demonstrated, which is ∼109 times larger than that of a conventional quartz crystal balance and ∼50 times higher than a conventional SAW device with a wavelength of 4 μm

Ecological Connectivity : Soft landscape design proposal for the dead points on the UBC campus

Human activities have changed the ecological function and structure of the environment, and the fragmented green space has reduced the ecosystem services. Therefore, it is very necessary to strengthen the connection between green spaces and create new soft landscapes so as to increase fauna habitats and improve the connection among habitats with high species richness and ecological potential. This report will analyze the isolated soft landscapes on the University of British Columbia (UBC) Vancouver campus that cannot connect to surrounding green spaces and then put forward effective soft landscape intervention schemes according to the current conditions of each site. Finally, we will visually present the comparison before and after implementing soft landscape interventions through GIS maps. The presented results of the GIS maps show that after the interventions are added near these isolated soft landscapes, all soft landscapes on campus overlap each other after adding a 10m buffer, which means that the connectivity among soft landscapes has been improved. Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”Forestry, Faculty ofUnreviewedUndergraduat

Design and Performance Assessment of Multi-Use Offshore Tension Leg Platform Equipped with an Embedded Wave Energy Converter System

In this study, a new multi-use offshore tension leg platform (TLP) was designed for wave energy production through an embedded wave energy converter (EWEC) system. The proposed EWEC system consists of four built-in tuned liquid column dampers for absorbing the hull motion energy and eight Wells turbines as the power take-off devices. A multifold nonlinear analytical model of this multibody system was developed considering the hydrodynamics of theTLP-EWEC system during large motions and the aerohydrodynamics of the chamber-turbine groups. A comprehensive assessment, including an evaluation of motion responses and preliminary generating capacity, was performed for different wave-load directions using the numerical time integration method. The results indicated that the multi-use platform can generate a considerable amount of turbine power for the offshore platform energy mix as well as serve for offshore oil and gas production in the target oil fields. Such additional benefits and profitability were proven effective and worthy for further exploration and practical application

Fibrin Glue-Kartogenin Complex Promotes the Regeneration of the Tendon-Bone Interface in Rotator Cuff Injury

Objective. Rotator cuff injury healing is problematic because the tendon-bone junction often forms cicatricial tissues, rather than fibrocartilage, which leads to mechanical impairment and is prone to redamage. Kartogenin (KGN) is a newly discovered small molecule compound which can induce cartilage formation through chondrogenesis of endogenous mesenchymal stem cells. Methods. In this study, we used KGN with fibrin glue (FG) to repair the rotator cuff injury by promoting the formation of fibrocartilage at the tendon to bone interface. Firstly, we assessed the release rate of KGN from the FG-KGN complex and then created a rabbit rotator cuff tendon graft-bone tunnel model. The rabbits received saline, FG-KGN, or FG injections onto the tendon to bone interface after injury. Shoulder tissues were harvested at 6 and 12 weeks, and the sections were stained with HE and Safranin O/Fast green. The samples were assessed by histologic evaluation and biomechanical testing. Synovial mesenchymal stem cells derived from the synovial tissue around the rotator cuff were harvested for western blotting and qRT-PCR analysis. Results. KGN was released rapidly from the FG-KGN complex during first 4 hrs and followed by a slow release until 7 days. The tendon graft-bone interface in the control (saline) group and the FG group was filled with scar tissue, rather than cartilage-like tissue, and only a small number of chondrocytes were found at the adjacent bone surface. In the FG-KGN group, the tendon to bone interface was fully integrated and populated by chondrocytes with proteoglycan deposition, indicating the formation of fibrocartilage-like tissues. At 12 weeks, the maximum tensile strength of the FG-KGN group was significantly higher than that of the FG and control groups (P<0.01). The RNA expression levels of tendinous genes such as Tenascin C and the chondrogenic gene Sox-9 were substantially elevated in SMSCs treated with the FG-KGN complex compared to the other two groups. Conclusion. These results indicated that fibrin glue is an effective carrier for KGN, allowing for the sustained release of KGN. The FG-KGN complex could effectively promote the regeneration and formation of fibrocartilage tissue of the tendon-bone interface in the rabbit rotator cuff tendon graft-bone tunnel model

High Performance Acoustic Wave Nitrogen Dioxide Sensor with Ultraviolet Activated 3D Porous Architecture of Ag-Decorated Reduced Graphene Oxide and Polypyrrole Aerogel

Surface acoustic wave (SAW) devices have been widely explored for real-time monitoring of toxic and irritant chemical gases such as nitrogen oxide (NO2), but they often have issues such as a complicated process of the sensing layer, low sensitivity, long response time, irreversibility, and/or requirement of high temperatures to enhance sensitivity. Herein, we report a sensing material design for room-temperature NO2 detection based on a 3D porous architecture of Ag-decorated reduced graphene oxide-polypyrrole hybrid aerogels (rGO-PPy/Ag) and apply UV activation as an effective strategy to further enhance the NO2 sensing performance. The rGO-PPy/Ag-based SAW sensor with the UV activation exhibits high sensitivity (127.68 Hz/ppm), fast response/recovery time (36.7 s/58.5 s), excellent reproducibility and selectivity, and fast recoverability. Its enhancement mechanisms for highly sensitive and selective detection of NO2 are based on a 3D porous architecture, Ag-decorated rGO-PPy, p-p heterojunction in rGO-PPy/Ag, and UV photogenerated carriers generated in the sensing layer. The scientific findings of this work will provide the guidance for future exploration of next-generation acoustic-wave-based gas sensors