Induced-charge electroosmosis around conducting and Janus cylinder in microchip

The induced-charge elecetroosmosis around conducting/Janus cylinder with arbitrary Debye thickness is studied numerically, when an direct current weak electric filed is suddenly applied in a confined microchannel. It’s found that there are four large circulations around the conducting cylinder, and the total flux in the microchannel is zero; there are two smaller circulations around the Janus cylinder, and they are compressed to wall. A bulk flux, which has a parabolic relation with the applied electric field, is also predicted

Alendronate (ALN) combined with Osteoprotegerin (OPG) significantly improves mechanical properties of long bone than the single use of ALN or OPG in the ovariectomized rats

<p>Abstract</p> <p>Background</p> <p>Alendronate (ALN) is the most common form of bisphosphonates used for the treatment of osteoporosis. Osteoprotegerin (OPG) has also been shown to reduce osteoporotic changes in both humans and experimental animals after systemic administration. The aim of this current study was to test if the anti-resorption effects of ALN may be enhanced when used in combination with OPG.</p> <p>Objectives</p> <p>To investigate the effects of ALN, OPG or combined on bone mass and bone mechanical properties in ovariectomized (OVX) rats.</p> <p>Methods</p> <p>OVX rats were treated with ALN, OPG-Fc, or OPG-Fc and ALN. Biochemical markers, trabecular bone mass, biomechanics, histomorphometry and RANKL expression in the bone tissues were examined following the treatments.</p> <p>Results</p> <p>The treatment of ALN, OPG-Fc and ALN+OPG-Fc all prevented bone loss in the OVX-rats, there was no statistical difference among the three treatment groups in terms of vertebrae BMD, mineralizing surfaces, mineral apposition rate, BFR/BS. The ALN+OPG-Fc treatment group had significantly increased the mechanical strength of lumber vertebral bodies and femoral shafts when compared to the ALN and OPG-Fc treatment groups. The RANKL protein expression in the vertebral bones was significantly decreased in the ALN and ALN+OPG-Fc treatment groups, suggesting the combined use of OPG-Fc and ALN might have amplified inhibition of bone resorption through inhibiting RANKL-dependent osteoclastogenesis.</p> <p>Conclusion</p> <p>The combined use of OPG-Fc and ALN may be a new treatment strategy for reversing bone loss and restoring bone quality in osteoprotic disorders.</p

A Social Referral Mechanism for Job Reference Recommendation

Recently, with the popularity of various social media, this new trend of information technologies has impacted our lives, redefined the way we interact with each other, and facilitated the communication and influence cross different social groups, such as enhancing the power of social search and appraisal. _x000D_ In this research, we mainly focus on this mystery process of information exchanges existing long ago on the base of sociology and apply this power in the field of job seeking. Considering the factors of both willingness and influence, we generate the list of proper reference candidates to desired job for job seekers to provide more job-related information or to be referrals. Integrating the knowledge of human resources management, we implement this social referral application with the support of information technologies and strive to enrich the service of social media, turning the passively searching for job seeking to actively consulting for exclusively job information._x000D