1 research outputs found
18F-Fluorocholine PET/CT, Tc-99m-MIBI and TC-99m-MDP SPECT/CT in Tertiary Hyperparathyroidism with Renal Osteodystrophy
Tertiary hyperparathyroidism (HPT) is a metabolic disorder characterized by the
semi-autonomous hypersecretion of parathyroid hormone (PTH), leading to hypercalcemia. It can
be the end result of persistent secondary hyperparathyroidism and is most commonly observed
in patients with long-standing chronic kidney disease (CKD) and often after renal transplantation.
Untreated HPT can lead to progressive bone disease, fibrocystic osteitis, and soft-tissue calcifications,
along with other severe complications. In the 2009 Kidney Disease Improving Global Outcomes
(KDIGO) guidelines, CKD-Mineral and Bone Disorder (CKD-MBD) is used to describe the broader
clinical syndrome encompassing mineral, bone, and calcific cardiovascular abnormalities that
develop as a complication of CKD. We report a 62-year-old female with a severe HPT evolved from
advanced chronic kidney disease (stage 5D, KDIGO). Patient was evaluated with multimodality
nuclear medicine functional imaging to assess hyperfunctioning parathyroid glands and bone lesions.
Tc-99m-methoxyisobutylisonitrile (MIBI) dual-phase scintigraphy, Tc-99m-methylenediphosphonate
(MDP) bone scan and 18F-Fluorocholine positron emission tomography/computed tomography
(
18F-FCH PET/CT) were performed before surgery