Відцентровий дезінтегратор з гідростатичною підвіскою розгінного ротора

Постановка проблеми. Стаття стосується випробовування відцентрового дезінтегратора ЦД-10 з гідростатичною підвіскою розгінного ротора. Мета. Введення у науковий обіг дослідницької інформації щодо результатів випробування дезінтегратора ЦД-10 для дроблення магнетитових руд, будівельних матеріалів і промислових відходів (пластин феритових магнітів). Методи і апаратура. Відцентровий дезінтегратор ЦД-10. Результати. Розроблена вітчизняна конструкція дезінтегратора відцентрового типу з гідростатичною підвіскою розгінного ротора. Проведені випробування дезінтегратора підтвердили його достатню працездатність і надійність та можливість отримання необ-хідних технологічних показників. Наукова цінність розробки. Випробувано інноваційну конструкцію відцентрованого дезінтегратора, особливістю якого є гідростатичний вузол підвіски ротора, який дозволяє зменшити дисбаланс ротора і вібраційні навантаження. Практичне значення. Встановлено високу ефективність застосування розробленої конструкції дезінтегратора ЦД-10 для дроблення магнетитових руд, будівельних матеріалів і промислових відходів. Науково-технічні розробки по гідростатичній підвісці розгінного ротора реалізовані при для дезінтегратора продуктивністю 5-10 т/год.Formulation of the problem. The article concerns the test of a centrifugal disintegrator СD-10 with hydrostatic suspension of an accelerating rotor. Goal. Introduction into scientific circulation of research information on the results of testing the СD-10 disintegrator for crushing ores, building materials and industrial waste (ferrite magnet plates). Methods and equipment. Centrifugal disintegrator CD-10. Results. A domestic design of a centrifugal disintegrator with a hydrostatic suspension of an accelerating rotor has been developed. The tests of the disintegrator confirmed its sufficient performance and reliability and the ability to obtain the necessary technological indicators. Scientific value of development. The innovative design of the centrifugal disintegrator is tested, the feature of which is the hydrostatic rotor suspension assembly. Such a unit that allows you to reduce the imbalance of the rotor and vibration loads. Practical value. The high efficiency of using the developed design of the CD-10 disintegrator for crushing ores, building materials and industrial waste has been established. Scientific and tech-nical developments on the hydrostatic suspension of an accelerating rotor are implemented for a disintegrator with a productivity of 5-10 t/h

Local laser heat treatment in dual-phase steels

This research deals with processes leading to local strengthening effects in hot-rolled dual-phase (DP) steels. For this purpose, a method was investigated to achieve local strengthening, namely, local laser heat treatment (LHT). DP sheet steels were globally and homogenously deformed with different degrees of prestrains by cold rolling and subsequently locally heat treated by laser. Following this treatment with selected parameters, the microstructure of the surface and cross section of the heat-treated area as well as the mechanical properties were evaluated by light optical microscopy (LOM), scanning electron microscopy (SEM), as well as transmission electron microscopy (TEM), hardness measurement, and tensile testing. It can be stated that with partial heat treatment, local high strengthening can be produced. At lower heat treating temperatures, this effect could be attributed to bake hardening (BH). Increasing the prestrain as well as temperature results in improving the local properties. With increased heat treating temperature, the initial microstructure near the surface is affected. Partial strengthening of DP steels by laser can open up new fields of application for locally using the strengthening effect to only influence relevant areas of interest, thus providing the potential for saving energy and designed the component\u27s behavior.<br /

Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

BACKGROUND: The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here, we describe novel effects of the class I HDAC inhibitor Entinostat on electrical and structural remodeling in an in vivo model of pacing induced heart failure. METHODS: Rabbits were implanted a pacemaker system, subjected to rapid ventricular pacing and treated with Entinostat or placebo, respectively. Following stimulation, rabbit hearts were explanted and subsequently subjected to electrophysiological studies and further immunohistological analyses of left ventricles. RESULTS: In vivo, rapid ventricular stimulation caused a significant prolongation of monophasic action potential duration compared to sham hearts (from 173 ± 26 ms to 250 ± 41 ms; cycle length 900 ms; p < 0.05) and an increased incidence of Early afterdepolarisations (+ 150%), while treatment with Entinostat in failing hearts could partially prevent this effect (from 250 ± 41 ms to 170 ± 53 ms, p < 0.05; reduction in EAD by 50%). Entinostat treatment partially restored KCNH2 and Cav1.3 gene expressions in failing hearts, and inhibited the development of cardiac fibrosis in vivo. CONCLUSION: In a rabbit model of heart failure, Entinostat diminishes heart failure related prolongation of repolarization and partially restores KCNH2 and Cav1.3 expression. In addition, Entinostat exerts antifibrotic properties both in vitro and in vivo. Thus, Entinostat might be an interesting candidate for the pharmaceutical therapy of heart failure directed against structural and electrical remodeling

Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

Abstract Background The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here, we describe novel effects of the class I HDAC inhibitor Entinostat on electrical and structural remodeling in an in vivo model of pacing induced heart failure. Methods Rabbits were implanted a pacemaker system, subjected to rapid ventricular pacing and treated with Entinostat or placebo, respectively. Following stimulation, rabbit hearts were explanted and subsequently subjected to electrophysiological studies and further immunohistological analyses of left ventricles. Results In vivo, rapid ventricular stimulation caused a significant prolongation of monophasic action potential duration compared to sham hearts (from 173 ± 26 ms to 250 ± 41 ms; cycle length 900 ms; p < 0.05) and an increased incidence of Early afterdepolarisations (+ 150%), while treatment with Entinostat in failing hearts could partially prevent this effect (from 250 ± 41 ms to 170 ± 53 ms, p < 0.05; reduction in EAD by 50%). Entinostat treatment partially restored KCNH2 and Cav1.3 gene expressions in failing hearts, and inhibited the development of cardiac fibrosis in vivo. Conclusion In a rabbit model of heart failure, Entinostat diminishes heart failure related prolongation of repolarization and partially restores KCNH2 and Cav1.3 expression. In addition, Entinostat exerts antifibrotic properties both in vitro and in vivo. Thus, Entinostat might be an interesting candidate for the pharmaceutical therapy of heart failure directed against structural and electrical remodeling