13 research outputs found
Use of chitosan and β-tricalcium phosphate, alone and in combination, for bone healing in rabbits
Effects of epicatechin, a crosslinking agent, on human dental pulp cells cultured in collagen scaffolds
Synthesis and biocompatibility assessment of a cysteine-based nanocomposite for applications in bone tissue engineering
Were VCF patients at higher risk of mortality following the 2009 publication of the vertebroplasty “sham” trials?
Chitosan-Based Matrices Prepared by Gamma Irradiation for Tissue Regeneration: Structural Properties vs. Preparation Method
Optimization of Chitosan-Gelatin Nanofibers Production: Investigating the Effect of Solution Properties and Working Parameters on Fibers Diameter
Cell studies of hybridized carbon nanofibers containing bioactive glass nanoparticles using bone mesenchymal stromal cells
Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells
Small animal models
Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic modalities prior to initiation of human clinical trials. Therefore, selecting a suitable experimental model for tissue engineering purposes is essential to establish valid conclusions. However, it remains important to be conscious of the advantages and limitations of the various small and large animal models frequently used for biomedical research as well as the different challenges encountered in extrapolating data obtained from animal studies and the risks of misinterpretation. This chapter discusses the various small animal model strategies used for osteochondral defect repair. Particular emphasis will be placed on analyzing the materials and strategies used in each model.FCT -Fundação para a Ciência e a Tecnologia(IF/00423/2012)info:eu-repo/semantics/publishedVersio