Country size and the trade effects of the euro

This paper investigates whether small countries gain relatively more than large countries from an 'expansion' of their market through the creation of a single currency. The introduction of the euro offers a particularly valuable source to test this hypothesis, which we motivate using the theoretical model by Casella of the year 1996. Our results from a panel data analysis, using both aggregate and disaggregated trade data, point to a statistically significant but quantitatively moderate small country bonus. On average, the euro has led to an improvement of the small euro area’s relative export performance by 3–9%

Trace Formulas for a Class of non-Fredholm Operators: A Review

We review previous work on spectral flow in connection with certain self-adjoint model operators $\{A(t)\}_{t\in \mathbb{R}}$ on a Hilbert space $\mathcal{H}$, joining endpoints $A_\pm$, and the index of the operator $D_{A}^{}= (d/d t) + A$ acting in $L^2(\mathbb{R}; \mathcal{H})$, where $A$ denotes the operator of multiplication $(A f)(t) = A(t)f(t)$. In this article we review what is known when these operators have some essential spectrum and describe some new results in terms of associated spectral shift functions. We are especially interested in extensions to non-Fredholm situations, replacing the Fredholm index by the Witten index, and use a particular $(1+1)$-dimensional model setup to illustrate our approach based on spectral shift functions.Comment: 46 pages. This is a review that in part extends the earlier arXiv:1509.01580, arXiv:1509.01356, and arXiv:1505.04895 submission

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts

Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by 120 min of reperfusion. The inhibitors were added to the perfusion fluid in various final concentrations from the beginning of the experiments before the coronary artery was blocked. Hemodynamic monitoring and biochemical analysis of perfusion fluid from the coronary outflow were carried out. Myocardial infarct size and the area at risk (transiently non-perfused myocardium) were determined from left ventricular slices after a special staining procedure with Evans blue and 2,3,5-triphenyltetrazolium chloride. The infarcted area (dead myocardium) was 77.9 +/- 2.3% of the area at risk in untreated controls (n=12). The infarct size was significantly reduced in the presence of both calpain inhibitors. The best effect was achieved with 10(-8) m A-705253 (n=8), which reduced (p<0.001) the infarcted area to 49.3 +/- 3.9% of the area at risk, corresponding to an infarct reduction of 61.8%. No statistical difference was observed between the experimental groups in coronary perfusion, left ventricular pressure, and in the release of lactate dehydrogenase and creatine kinase from heart muscle