632 research outputs found
An Analysis of National Economic Stimulus Programs in Response to the Economic and Financial Crisis
This research traces the sources of differences in national economic stimulus
programs designed and set up in response to the economic crisis 2008/09. Based
on a comparative case study of the stimulus programs of Germany and France, I
argue that differences in the national configuration of the economies and not
solely economic preconditions explain the diverging outcomes. Using Vivien
Schmidt’s “Varieties of Capitalism”-framework from 2002, I show that
corporatist traditions still have a significant impact on policy outcomes in
Germany whereas in France various interest groups have to cope with differing
conditions for influence exertion. In fact, the balance between social- and
business-supporting measures of the German stimulus program is a prime example
of the German state as an “enabling facilitator”. The French stimulus program,
that is significantly smaller in contrast to its German counterpart, exhibits
a strong support of the industry reflecting the weak position of trade-unions
vis-à-vis businesses and the state. Overall, the paper provides a
comprehensive approach to comparativist policy-research by taking into account
economic, institutional and political factors. It shall serve as the starting
point for further research in the field of governmental interventions during
the crises of the recent years
Loads of Work for Communication Scholars: Gender, Parenthood and Burden during the COVID-19 Pandemic
Die Studie nimmt die Arbeitsbedingungen von Kommunikationswissenschaftler:innen in den Blick und untersucht, inwieweit Ungleichheiten hinsichtlich Geschlecht und Elternschaft während der COVID-19-Pandemie zugenommen haben. Dabei wird im Besonderen die Verbindung zwischen der beruflichen Tätigkeit von sich als weiblich identifizierenden Kommunikationswissenschaftlerinnen, der Verteilung häuslicher Betreuungsaufgaben und dem Belastungsempfinden in beruflichen und privaten Bezügen fokussiert. Im Zentrum steht die Frage, welche Belastungen Kommunikationswissenschaftler:innen während der ersten anderthalb Jahre der Pandemie wahrgenommen haben und wie diese sich aus beruflichen Zusammenhängen und den Lebensverhältnissen erklären lassen. Die Ergebnisse zeigen, dass Eltern, insbesondere von jüngeren Kindern, eine erhöhte berufliche Stressbelastung verspürten. Überraschenderweise sind die geschlechtsgebundenen Unterschiede nicht so ausgeprägt wie erwartet: Kommunikationswissenschaftlerinnen, die sich als Frauen identifizieren, fühlen sich nicht stärker belastet als ihre sich als Männer identifizierenden Kollegen.The paper focuses on academic work in communication studies. It discusses whether inequalities related to gender and parenthood have widened during the COVID-19 pandemic, especially concerning the interrelation of women's paid work and the division of caring responsibilities. It discusses how communication scholars perceived the burden during the first year and a half of the pandemic. The results show that parents, especially those of younger children, report feeling the highest level of stress concerning their working life. Surprisingly, gender differences are not as distinct as expected: Communication scholars identifying as female do not perceive themselves as more burdened than their colleagues who identify as male
Gender-related traits as predictors of alcohol use in male German and Spanish university students
This study examined instrumental (masculine
stereotyped) and expressive (feminine stereotyped) personality traits and alcohol use among men from Germany and Spain. Participants were 161 male university students (76 German, M-age=23 years; 77 Spanish, M-age=22 years), who
completed either a daytime or a nighttime drinking questionnaire, each including a Short Form of the Bem Sex Role Inventory. Poisson regression analyses with latent
predictors were conducted. The trait factors and their
interactions with nationality predicted daytime and nighttime alcohol use. The results add support to the assumption that alcohol use is associated with the construction of masculinity and that internalization of traditionally female attributes protects against health-risk behaviors such as alcohol consumption
Career, Covid-19, and Care: (Gendered) Impacts of the Pandemic on the Work of Communication Scholars
The study at hand analyzes the impact of the Covid-19 pandemic and related restrictions on scholars in the area of media and communication studies. It aims to highlight inequalities in the negative effects of the pandemic on academic output by examining the working conditions of scholars, taking into account gender, parenthood, and the partnership-based division of professional and care work. The quantitative survey was directed at communication scholars in Germany, Austria, and Switzerland. The findings show that there are no significant gender differences in terms of changes in academic output during the first 15 months of the pandemic; instead, disadvantages were observed in terms of parenting, regardless of the gender of the parents. Gender-specific effects could be detected concerning family situations and partnerships. Here, male participants are more often found in relationships in which the partner only works half-time, than women who mostly live with a partner who works full-time. The data suggest that gender differences related to changes in the time allotted for professional and care work and academic output are leveled out by the characteristics of the academic career model in which German-speaking scholars work. Nevertheless, gendered structures in academia and partnerships shape how the impact of the pandemic on professional work is experienced
Adenocarcinoma of the cervix uteri : methods to improve diagnostics : biological markers and HPV testing
Cervical adenocarcinoma (ADC) represents about 20%
of invasive
cervical cancers.
Implementation of screening programs that have led to a decrease in squamous cell
carcinoma
(SCC)
has only had a limited preventive effect on
adenocarcinoma as
the
incidence of ADC,
especially among younger
women, has steadily increased in recent
decades. Human papillomavirus (HPV) is considered the most important
single
factor
for development of
SCC. Adenocarcinomas of the cervix are also related to HPV
of
high risk types (HR-HPV), but the correlation is less pronounced.
HPV infection alone
is insufficient
and other factors are required
for oncogenic transformation to
ADC.
The aim of this thesis is to investigate molecular markers such as
tumor suppressor
p16 [INK4a], proliferation marker Ki-67, possible tumor
suppressor proteins in the
LRIG
family, the
TP53 target WIG-1, and E6/E7 mRNA
in cervical adenocarcinoma in order
to
provide a deeper understanding of the etiology
of the disease
and to develop more
efficient screening strategies for adenocarcinoma of the
cervix.
Formalin-fixed/paraffin-embedded tumor tissue samples of cervical
ADC were
investigated by immunohistochemistry
(IHC)
for the occurrence of
p16[INK4a]
using the
CINtec® kit,
of
Ki-67 with the MIB-1 antibody, and
of
LRIG1, LRIG2 and LRIG3
using polyclonal rabbit antibodies. In 38 samples
of cervical cancer (ADC or SCC), Wig-1
was examined by
IHC
using a monoclonal antibody. In
cervical cancer
cell lines
the WIG-1 gene locus was investigated by SKY, CGH, Southern and FISH; mRNA
expression by Northern
and RT-PCR;
and protein expression by Western analysis.
Testing for E6/E7 mRNA was carried out using the PreTect HPV Proofer; testing for
HR-HPV DNA was done by consensus PCR and subsequent typing by SSCP, direct
sequencing and Linear Array®. The examined markers were evaluated regarding
prognostic impact and association with HPV infection.
We found that poorly differentiated tumors
stain with less intensity and in a lower
fraction than do well
differentiated tumors. All HPV-positive tumors showed
p16[INK4a]
staining, but 60% of HPV-negative tumors also stained for
p16[INK4a].
We found a
significant correlation between staining for Ki-67 and histological grade (p=0.031)
as
well as worse outcome (p=0.004).
High staining intensity for LRIG1 and a high fraction of LRIG3-positive cells were
significantly associated with improved patient survival (p=0.03 and p=0.04). LRIG1
and LRIG3 expression correlated with HPV infection, since higher staining intensity
was observed in HR-HPV-positive cases.
mRNA extraction from paraffin-embedded tissue samples was successful, as shown by
positive results in the GAPDH mRNA integrity control in all cases. HR-HPV infection
was detected by mRNA in 64% of the tumors, compared with detection by DNA in
62% of the tumors. There was an 87%
agreement in results between the two methods
regarding HPV positivity and 84% agreement regarding HPV type.
WIG-1 is not the primary target for genomic alteration on chromosome 3, even though
analysis revealed chromosome 3 gains in all lines. WIG-1 mRNA expression was
higher in the two HPV-negative cervical cell lines (C33-A, HT-3) than in the HPV-positive lines. Wig-1 expression in tumor tissue, as assessed by IHC, showed
significantly higher nuclear Wig-1 levels in ADC than in SCC (p<0.0001). We
observed
higher nuclear Wig-1 expression in the HPV-negative tumors than in HPV-positive tumors (p= 0.002). Patients with tumors that demonstrated moderate nuclear
and positive cytoplasmic Wig-1 expression had a better prognosis (p = 0.042) than
those with high nuclear and negative cytoplasmic Wig-1 expression.
According to our findings the tested markers appear to be potential diagnostic
supplements for cervical adenocarcinoma
as expression of
Wig-1
as well as LRIG1 and
LRIG3 could
serve as
prognostic markers,
p16[INK4a]
and Ki-67 might be helpful markers
for grading endocervical malignancies
and mRNA testing has been shown to be as
sensitive as DNA testing.
The combination of improved detection of precursors through
integration of molecular markers into screening programs
with
vaccination
against HPV 16 and 18 will help cervical cancer including adenocarcinoma to become one of
the most preventable cancers
Interfaces in partly compatible polymer mixtures: A Monte Carlo simulation approach
The structure of polymer coils near interfaces between coexisting phases of
symmetrical polymer mixtures (AB) is discussed, as well as the structure of
symmetric diblock copolymers of the same chain length N adsorbed at the
interface. The problem is studied by Monte Carlo simulations of the bond
fluctuation model on the simple cubic lattice, using massively parallel
computers (CRAY T3D). While homopolymer coils in the strong segregation limit
are oriented parallel to the interface, the diblocks form ``dumbbells''
oriented perpendicular to the interface. However, in the dilute case
(``mushroom regime'' rather than ``brush regime''), the diblocks are only
weakly stretched. Distribution functions for monomers at the chain ends and in
the center of the polymer are obtained, and a comparison to the self consistent
field theory is made.Comment: to appear in Physica
Leistungsprüfung verschiedener Hühnerherkünfte mit Blick auf mögliche Zweinutzung – b) weibliche Tiere
Ziel der Studie war es, verschiedene Herkünfte in Hinblick auf eine mögliche Zweinutzung zu testen. Auf einem Versuchs- und vier Biobetrieben (insgesamt 800 Hennen) wurden drei Rassehühner und eine Kreuzungsherkunft eines Bio-Zuchtbetriebes verglichen. Die Kreuzung Domäne Gold hatte die höchste Legeleistung, gefolgt von Bresse. Die Rassen wurden in verschiedenen Tierschutzindikatoren (z.B. Auslaufnutzung, Gefiederzustand) unterschiedlich eingestuft
Longitudinal Assessment of In Vivo Bone Dynamics in a Mouse Tail Model of Postmenopausal Osteoporosis
Recently, it has been shown that transient bone biology can be observed in vivo using time-lapse micro-computed tomography (μCT) in the mouse tail bone. Nevertheless, in order for the mouse tail bone to be a model for human disease, the hallmarks of any disease must be mimicked. The aim of this study was to investigate whether postmenopausal osteoporosis could be modeled in caudal vertebrae of C57Bl/6mice, considering static and dynamic bone morphometry as well as mechanical properties, and to describe temporal changes in bone remodeling rates. Twenty C57Bl/6mice were ovariectomized (OVX, n=11) or sham-operated (SHM, n=9) and monitored with in vivo μCT on the day of surgery and every 2weeks after, up to 12weeks. There was a significant decrease in bone volume fraction for OVX (−35%) compared to SHM (+16%) in trabecular bone (P<0.001). For OVX, high-turnover bone loss was observed, with the bone resorption rate exceeding the bone formation rate (P<0.001). Furthermore there was a significant decrease in whole-bone stiffness for OVX (−16%) compared to SHM (+11%, P<0.001). From these results we conclude that the mouse tail vertebra mimics postmenopausal bone loss with respect to these parameters and therefore might be a suitable model for postmenopausal osteoporosis. When evaluating temporal changes in remodeling rates, we found that OVX caused an immediate increase in bone resorption rate (P<0.001) and a delayed increase in bone formation rate (P<0.001). Monitoring transient bone biology is a promising method for future researc
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