On assortative and disassortative mixing in scale-free networks: The case of interbank credit networks

Networks constructed from credit relationships in the interbank market have been found to exhibit disassortative mixing together with a scale-free degree distribution, in contrast to most social networks that are assortative and not necessarily scale-free. This provokes the question whether generating mechanisms for scale-free networks have enough flexibility to generate both assortative and disassortative structures depending on their parametrization. Using Monte-Carlo simulations, we show that scale-free networks with a small tail exponent tend to be disassortative. However, the simulations indicate also that the level of disassortativity is sensitive to changes in the scaling exponent and the density. A given combination of disassortativity, scaling of the degree distribution, and density in an empirical data set, might be hard or impossible to obtain from any of the known generating mechanisms for scale-free networks

Was tun mit dem unerwarteten Plus an Steuereinnahmen?

Durch den laufenden Konjunkturaufschwung hat sich die Lage der deutschen Staatshaushalte deutlich verbessert. Der Arbeitskreis »Steuerschätzungen« für Bund, Länder und Gemeinden geht in seiner Mai-Prognose von annähernd 180 Mrd. € zusätzlichen Einnahmen der öffentlichen Haushalte für die Jahre 2007 bis 2010 aus. Was tun mit dem unerwarteten »Steuer-Plus«? Wolfgang Wiegard, Universität Regensburg und Sachverständigenrat, ist dafür, dass nach Erreichung konjunkturell ausgeglichener öffentlicher Haushalte die verbleibenden Steuermehreinnahmen über Steuersenkungen an die Bürger zurückgegeben werden sollten. Thomas Straubhaar, HWWI, schlägt u.a. vor, das Geld in Form eines Barschecks unmittelbar an die Steuerzahlenden zurückzuerstatten. Joachim Poß, SPD-Bundestagsfraktion, macht die Ansicht der Koalition und Otto Fricke, Haushaltsausschuss des Deutschen Bundestags, die der FDP-Fraktion vorstellig. Karl Heinz Däke, Bund der Steuerzahler, möchte »Neuverschuldung abbauen und Steuerentlastung auf den Weg bringen«

Was tun mit dem unerwarteten Plus an Steuereinnahmen?

Durch den laufenden Konjunkturaufschwung hat sich die Lage der deutschen Staatshaushalte deutlich verbessert. Der Arbeitskreis »Steuerschätzungen« für Bund, Länder und Gemeinden geht in seiner Mai-Prognose von annähernd 180 Mrd. € zusätzlichen Einnahmen der öffentlichen Haushalte für die Jahre 2007 bis 2010 aus. Was tun mit dem unerwarteten »Steuer-Plus«? Wolfgang Wiegard, Universität Regensburg und Sachverständigenrat, ist dafür, dass nach Erreichung konjunkturell ausgeglichener öffentlicher Haushalte die verbleibenden Steuermehreinnahmen über Steuersenkungen an die Bürger zurückgegeben werden sollten. Thomas Straubhaar, HWWI, schlägt u.a. vor, das Geld in Form eines Barschecks unmittelbar an die Steuerzahlenden zurückzuerstatten. Joachim Poß, SPD-Bundestagsfraktion, macht die Ansicht der Koalition und Otto Fricke, Haushaltsausschuss des Deutschen Bundestags, die der FDP-Fraktion vorstellig. Karl Heinz Däke, Bund der Steuerzahler, möchte »Neuverschuldung abbauen und Steuerentlastung auf den Weg bringen«.Steueraufkommen, Steuersenkung, Einkoomensteuer, Steuerbegünstigung, Steuerreform, Deutschland

E+E-Projekt „Integration von Naturschutzzielen in den Ökologischen Landbau am Beispiel der Hessischen Staatsdomäne Frankenhausen“ - Maßnahmen zur Entwicklung dauerhafter Landschaftsstrukturen

The Hessian state domain Frankenhausen near Kassel was converted to organic farming in July 1998 and serves as a research and demonstration farm of the univer-sity. Before that time the farm changed constantly by typical intensification of conven-tional farming: The landscape is a mirror of intense use: cleared and drained fields, canalised brooks and large fields with few structural elements. – Within the project “The Integration of Nature Conservation into Organic Farming” (supported by the German Federal Agency for Nature Conservation with funds from the Federal Envi-ronmental Ministry) and based on the analysis of the present situation using methods of landscape ecology. Measures to restore brooks, structural elements and biotopes are to be implemented. The aim is to integrate structural elements like hedgerows into the farm management

Factors influencing brightness and beam quality of conventional and distributed Bragg reflector tapered laser diodes in absence of self-heating

In this study, the authors examine some of the factors affecting the brightness and the beam quality of high-power tapered lasers. The large volume resonators required to achieve a high-power, high-brightness operation make the beam quality sensitive to carrier lensing and a multimode operation. These cause bleaching of the regions outside the ridge waveguide. The beam quality in the conventional and the distributed Bragg reflector tapered lasers is examined in the absence of the self-heating effects to investigate the effect of the carrier lensing effects. The influence of the front facet reflectivity and the taper angle on the beam quality is investigated. The beam quality was found to degrade with an increase in the front facet reflectivity and for the larger taper angles in the conventional tapered lasers, especially at low ridge waveguide currents. Finally, the performance of the conventional tapered lasers employing a beamspoiler was assessed. The beam quality was found to be comparable with that achieved in the DBR tapered lasers

which marker is best for prediction? Pooled analysis of four German population-based cohort studies and comparison with a nationwide cohort study

Objective To compare the association between different anthropometric measurements and incident type 2 diabetes mellitus (T2DM) and to assess their predictive ability in different regions of Germany. Methods Data of 10 258 participants from 4 prospective population-based cohorts were pooled to assess the association of body weight, body mass index (BMI), waist circumference (WC), waist-to-hip-ratio (WHR) and waist-to-height-ratio (WHtR) with incident T2DM by calculating HRs of the crude, adjusted and standardised markers, as well as providing receiver operator characteristic (ROC) curves. Differences between HRs and ROCs for the different anthropometric markers were calculated to compare their predictive ability. In addition, data of 3105 participants from the nationwide survey were analysed separately using the same methods to provide a nationally representative comparison. Results Strong associations were found for each anthropometric marker and incidence of T2DM. Among the standardised anthropometric measures, we found the strongest effect on incident T2DM for WC and WHtR in the pooled sample (HR for 1 SD difference in WC 1.97, 95% CI 1.75 to 2.22, HR for WHtR 1.93, 95% CI 1.71 to 2.17 in women) and in female DEGS participants (HR for WC 2.24, 95% CI 1.91 to 2.63, HR for WHtR 2.10, 95% CI 1.81 to 2.44), whereas the strongest association in men was found for WHR among DEGS participants (HR 2.29, 95% CI 1.89 to 2.78). ROC analysis showed WHtR to be the strongest predictor for incident T2DM. Differences in HR and ROCs between the different markers confirmed WC and WHtR to be the best predictors of incident T2DM. Findings were consistent across study regions and age groups (<65 vs ≥65 years). Conclusions We found stronger associations between anthropometric markers that reflect abdominal obesity (ie, WC and WHtR) and incident T2DM than for BMI and weight. The use of these measurements in risk prediction should be encouraged

Anthropometric markers and their association with incident type 2 diabetes mellitus: which marker is best for prediction? Pooled analysis of four German population-based cohort studies and comparison with a nationwide cohort study

Objective: To compare the association between different anthropometric measurements and incident type 2 diabetes mellitus (T2DM) and to assess their predictive ability in different regions of Germany. Methods: Data of 10 258 participants from 4 prospective population-based cohorts were pooled to assess the association of body weight, body mass index (BMI), waist circumference (WC), waist-to-hip-ratio (WHR) and waist-to-height-ratio (WHtR) with incident T2DM by calculating HRs of the crude, adjusted and standardised markers, as well as providing receiver operator characteristic (ROC) curves. Differences between HRs and ROCs for the different anthropometric markers were calculated to compare their predictive ability. In addition, data of 3105 participants from the nationwide survey were analysed separately using the same methods to provide a nationally representative comparison. Results: Strong associations were found for each anthropometric marker and incidence of T2DM. Among the standardised anthropometric measures, we found the strongest effect on incident T2DM for WC and WHtR in the pooled sample (HR for 1 SD difference in WC 1.97, 95% CI 1.75 to 2.22, HR for WHtR 1.93, 95% CI 1.71 to 2.17 in women) and in female DEGS participants (HR for WC 2.24, 95% CI 1.91 to 2.63, HR for WHtR 2.10, 95% CI 1.81 to 2.44), whereas the strongest association in men was found for WHR among DEGS participants (HR 2.29, 95% CI 1.89 to 2.78). ROC analysis showed WHtR to be the strongest predictor for incident T2DM. Differences in HR and ROCs between the different markers confirmed WC and WHtR to be the best predictors of incident T2DM. Findings were consistent across study regions and age groups

A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity

Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory signals that boost T cell activation, differentiation, and survival. Agonistic stimulation of CD27 is therefore a promising therapeutic concept in immuno-oncology intended to boost and sustain T cell driven anti-tumor responses. Endogenous TNFSF/TNFRSF-based signal transmission is a structurally well-defined event that takes place during cell-to-cell-based contacts. It is well-established that the trimeric-trivalent TNFSF-receptor binding domain (TNFSF-RBD) exposed by the conducting cell and the resulting multi-trimer-based receptor clustering on the receiving cell are essential for agonistic signaling. Therefore, we have developed HERA-CD27L, a novel hexavalent TNF receptor agonist (HERA) targeting CD27 and mimicking the natural signaling concept. HERA-CD27L is composed of a trivalent but single-chain CD27L-receptor-binding-domain (scCD27L-RBD) fused to an IgG1 derived silenced Fc-domain serving as dimerization scaffold. The hexavalent agonist significantly boosted antigen-specific T cell responses while having no effect on non-specific T cells and was superior over stabilized recombinant trivalent CD27L. In addition, HERA-CD27L demonstrated potent single-agent anti-tumor efficacy in two different syngeneic tumor models, MC38-CEA and CT26wt. Furthermore, the combination of HERA-CD27L and an anti-PD-1 antibody showed additive anti-tumor effects highlighting the importance of both T cell activation and checkpoint inhibition in anti-tumor immunity. In this manuscript, we describe the development of HERA-CD27L, a true CD27 agonist with a clearly defined forward-signaling mechanism of action

Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort

Background: Global incidence of type 1 diabetes (T1D) is rising and nearly half occurred in adults. However, it is unclear if certain early-life childhood T1D risk factors were also associated with adult-onset T1D. This study aimed to assess associations between birth order, delivery mode or daycare attendance and type 1 diabetes (T1D) risk in a population-based cohort and whether these were similar for childhood- and adult-onset T1D (cut-off age 15); (2) Methods: Data were obtained from the German National Cohort (NAKO Gesundheitsstudie) baseline assessment. Self-reported diabetes was classified as T1D if: diagnosis age ≤ 40 years and has been receiving insulin treatment since less than one year after diagnosis. Cox regression was applied for T1D risk analysis; (3) Results: Analyses included 101,411 participants (100 childhood- and 271 adult-onset T1D cases). Compared to “only-children”, HRs for second- or later-born individuals were 0.70 (95% CI = 0.50–0.96) and 0.65 (95% CI = 0.45–0.94), respectively, regardless of parental diabetes, migration background, birth year and perinatal factors. In further analyses, higher birth order reduced T1D risk in children and adults born in recent decades. Caesarean section and daycare attendance showed no clear associations with T1D risk; (4) Conclusions: Birth order should be considered in both children and adults’ T1D risk assessment for early detection