Überblick über die neueren Arbeiten auf dem Gebiet des Wasserstoff-und Tritiumverhaltens in Hochtemperaturreaktoren

This report comprises the contributions of members of the "Institut für Reaktor-Entwicklung" (IRE) to the "Und Seminar on Hydrogen and Tritium Behaviour in High Temperature Reactors", which was held March 8, 1978, at KFA Jülich. At the beginning the problem is introduced and the investigations at IRE related to this area are presented in their context. Then follow the individual papers on the subjects mentioned. At first the experiences with the operation of the experimental facility AUWARM and the newest results in the current testing program are discussed. Therafter the model investigations with hydrogen and deuterium on the problem of hydrogen- and tritium permeation are reported and a computer program for balancing tritium in pebble-bed-HTRs is described. Last notleast the studies on the behaviour of tritium in matrix graphite and the experiments on primary coolant purification by titanium gettering are shortly communicated. The results given in this report are preliminary informations on the actual status of the current investigations

Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: From treatment to prevention

The HIV epidemic continues unabated, with no highly effective vaccine and no cure. Each new infection has significant economic, social and human costs and prevention efforts are now as great a priority as global antiretroviral therapy (ART) scale up. Reverse transcriptase inhibitors, the first licensed class of ART, have been at the forefront of treatment and prevention of mother to child transmission over the past two decades. Now, their use in adult prevention is being

Large-scale, prospective, observational studies in patients with psoriasis and psoriatic arthritis: A systematic and critical review

<p>Abstract</p> <p>Background</p> <p>Observational studies, if conducted appropriately, play an important role in the decision-making process providing invaluable information on effectiveness, patient-reported outcomes and costs in a real-world environment. We conducted a systematic review of large-scale, prospective, cohort studies with the aim of (a) summarising design characteristics, the interventions or aspects of the disease studied and the outcomes measured and (b) investigating methodological quality.</p> <p>Methods</p> <p>We included prospective, cohort studies which included at least 100 adults with psoriasis or psoriatic arthritis. Studies were identified through searches in electronic databases (Pubmed, Medline, Cochrane library, Centre for Reviews and Dissemination). Information on study characteristics were extracted and tabulated and quality assessment, using a checklist of 18 questions, was conducted.</p> <p>Results</p> <p>Thirty five papers covering 16 cohorts met the inclusion criteria. There were ten treatment-related studies, only two of which provided a comparison between treatments, and six non-treatment studies which examined a number of characteristics of the disease including mortality, morbidity, cost of illness and health-related quality of life. All studies included a clinical outcome measure and 11 included patient-reported outcomes, however only two studies reported information on patient utilities and two on costs. The quality of the assessed studies varied widely. Studies did well on a number of quality assessment questions including having clear objectives, documenting selection criteria, providing a representative sample, defining interventions/characteristics under study, defining and using appropriate outcomes, describing results clearly and using appropriate statistical tests. The quality assessment criteria least adhered to involved questions regarding sample size calculations, describing potential selection bias, defining and adjusting for confounders and losses to follow-up, and defining and describing a comparison group.</p> <p>Conclusion</p> <p>The review highlights the need for well designed prospective observational studies on the effectiveness, patient-reported outcomes and economic impact of treatment regimes for patients with psoriasis and psoriatic arthritis in a real-world environment.</p

Vortrag über die sanitätspolizeilichen Verhältnisse der Stadt Coblenz, mit Rücksicht auf die Trinkwasser-Frage : gehalten in der Generalversammlung des hies. Zweigvereins für Öffentl. Gesundheitspflege am 3. Mai 1870

von Landrath von Frent

The minority protection system of the League of Nations in relation to the German minority in Poland, 1920-1934

SIGLEAvailable from British Library Document Supply Centre-DSC:D203444 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Direkte Endlagerung ausgedienter Brennelemente DEAB Strahlenexposition im bestimmunsgemaessen Betrieb

The collective dose to the personnel from external irradiation and inhalation is below 10% of the occupational dose limit for personnel belonging to category A defined according to section 49 StrlSchV (German radiation protection ordinance). The potential radiation exposure of the population, adults and infants, is derived via the airborne exposure pathway. The results show that the derived doses are markedly below the dose limits defined in section 45 StrlSchV, despite the very conservative figures used for the emission source strength. The radiation dose to the lungs of an infant, for instance, is derived to be below 4% of the dose limit. (HP)Die Kollektivdosis des Betriebspersonals durch aeussere Strahlung und Inhalation liegt unterhalb 10% des Dosisgrenzwertes fuer beruflich exponierte Personen der Kategorie A nach Paragraph 49 StrlSchV. Die potentielle Strahlenexposition wird fuer Erwachsene und Kleinkind berechnet via Ableitung durch den Luftpfad. Die Grenzwerte des Paragraph 45 StrlSchV werden deutlich unterschritten trotz der sehr konservativ ausgesetzten Emissionsquellstaerke. Im Fall der Lunge beim Kleinkind liegt die Strahlenbelastung unter 4% des Grenzwertes. (HP)Available from TIB Hannover: RO 6452(52)+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Building the safety case for a hypothetical underground repository in crystalline rock. Final report. Vol. 2 Safety file

The study was intended as a desk simulation of the process of preparing a licensing application for a deep repository for spent fuel and high level waste in crystalline rock. After clarifying of organizational aspects of table of contents specifying all aspects in a safety life for license application were considered. The volume II is subdivided in two parts. Part A describes the general information, waste description, site characteristics, disposal facility design, reporitory construction and operation, quality assurance, operational safety, repository closure, organization and financial aspects, and long-term safety assessment. Part B deals with the impact of retrievability. (DG)SIGLEAvailable from TIB Hannover: F97B306+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany); European Union (Euro), Brussels (Belgium)DEGerman