10 research outputs found
Amblyomma auricularium (Acari: Ixodidae): underwater survival of the non-parasitic phase of feeding females
New host records for Amblyomma rotundatum (Acari: Ixodidae) from Grussaí restinga, Rio de Janeiro, Brazil
Perfil dos cuidadores e as dificuldades enfrentadas no cuidado ao idoso, em Ananindeua, PA
Departamento Científico de Enfermagem Gerontológica da Associação Brasileira de Enfermagem
Cognitive function of elderly residents in long-term institutions: effects of a physiotherapy program
The life cycle of Amblyomma auricularium (Acari: Ixodidae) using rabbits (Oryctolagus cuniculus) as experimental host
Telomere maintenance and length regulation in Trypanosoma brucei
Transcription of telomere proximal variant surface glycoprotein genes is mono-allelic in bloodstream-form Trypanosoma brucei. The terminal DNA sequence at these telomeres consists of tandem T(2)AG(3) repeats, which increase in length by ∼8 bp per cell division balanced by occasional loss of large numbers of repeats. Here we have used targeted chromosome fragmentation to investigate the sequence requirements for telomere formation in T.brucei. Telomere formation is most efficient on tandem T(2)AG(3) repeats, but can also occur on specific templates found within ‘random’ sequence substrates and on G-rich motifs proximal to a double-strand break. Newly formed telomeres are extended faster than other native telomeres, but as the telomere becomes longer the rate of extension declines. Telomere length regulation in T.brucei is discussed in the context of recent results from other cell types