Conformation-regulated mechanosensory control via titin domains in cardiac muscle

The giant filamentous protein titin is ideally positioned in the muscle sarcomere to sense mechanical stimuli and transform them into biochemical signals, such as those triggering cardiac hypertrophy. In this review, we ponder the evidence for signaling hotspots along the titin filament involved in mechanosensory control mechanisms. On the way, we distinguish between stress and strain as triggers of mechanical signaling events at the cardiac sarcomere. Whereas the Z-disk and M-band regions of titin may be prominently involved in sensing mechanical stress, signaling hotspots within the elastic I-band titin segment may respond primarily to mechanical strain. Common to both stress and strain sensor elements is their regulation by conformational changes in protein domains

Untersuchung von Photoprozessen in freien Atomen und Molekuelen ueber Elektronenspektrometrie, Ionenanalyse und Koinzidenzmessungen Schlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(5,8) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

Untersuchung von Photoprozessen in freien Atomen und Molekuelen durch die Einbeziehung verschiedenartiger Koinzidenzmessungen Schlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(43,44) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Psychophysiologische Untersuchungen zum Schul- und Freizeitverhalten bei Gymnasiasten der 5. und 6. Klassen

UuStB Koeln(38)-930107704 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman