Quality of Life in Youth with Bipolar Disorder and Trauma

Background:Epidemiological work suggests that youth with histories of trauma or bipolar disorder have lower quality of life (QoL) than generally healthy youth without a history of bipolar disorder or trauma. Aim: To evaluate whether trauma and bipolar disorder have a negative effect in youth seeking services for emotional and behavioral difficulties. Method & Sample: Participants were 596 youths and caregiver dyads from an urban community mental health center and an academic medical center in Cleveland, OH. Diagnoses were based on semi-structured interviews of the parent and youth. The KINDL-R measured Total, Emotional, Self-esteem, Family, Friend, School, and Physical QoL. Results: Trauma history was not associated with changes in QoL. Youth with bipolar disorder had significantly lower QoL than youth without bipolar disorder. There was no interaction between trauma history and bipolar disorder. Conclusion: Among youth seeking mental health services, trauma history was common. A history of trauma does not alter QoL compared to youth without a history of QoL in a service seeking sample. Youth with bipolar disorder had significantly lower QoL than youth without bipolar disorder suggesting that youth with bipolar disorder might require more intensive services than youth without bipolar disorder

CMS Central Hadron Calorimeter

We present a description of the CMS central hadron calorimeter. We describe the production of the 1996 CMS hadron testbeam module. We show the results of the quality control tests of the testbeam module. We present some results of the 1995 CMS hadron testbeam.Comment: 7 pages, 11 Figures, corresponding author: H. Budd, [email protected]

More pieces of the puzzle: Chemistry and substructures in the Galactic thick disk

We present a study of the chemical abundances of Solar neighbourhood stars associated to dynamical structures in the Milky Way's (thick) disk. These stars were identified as overdensity in the eccentricity range 0.3< ecc < 0.5 in the Copenhagen-Geneva Survey by Helmi et al. (2006). We find that the stars with these dynamical characteristics do not constitute a homogeneous population. A relatively sharp transition in dynamical and chemical properties appears to occur at a metallicity of [Fe/H] ~ -0.4. Stars with [Fe/H] > -0.4 have mostly lower eccentricities, smaller vertical velocity dispersions, are alpha-enhanced and define a rather narrow sequence in [alpha/Fe] vs [Fe/H], clearly distinct from that of the thin disk. Stars with [Fe/H] < -0.4 have a range of eccentricities, are hotter vertically, and depict a larger spread in [alpha/Fe]. We have also found tentative evidence of substructure possibly associated to the disruption of a metal-rich star cluster. The differences between these populations of stars is also present in e.g. [Zn/Fe], [Ni/Fe] and [SmII/Fe], suggesting a real physical distinction.Comment: Astrophysical Journal in press. 5 pages, 4 figure

Differential chemical abundance analysis of a 47 Tuc AGB star with respect to Arcturus

This study resolves a discrepancy in the abundance of Zr in the 47 Tucanae asymptotic giant branch star Lee 2525. This star was observed using the echelle spectrograph on the 2.3 m telescope at Siding Spring Observatory. The analysis was undertaken by calibrating Lee 2525 with respect to the standard giant star Arcturus. This work emphasises the importance of using a standard star with stellar parameters comparable to the star under analysis rather than a calibration with respect to the Sun (Koch & McWilliam 2008). Systematic errors in the analysis process are then minimised due to the similarity in atmospheric structure between the standard and programme stars. The abundances derived for Lee 2525 were found to be in general agreement with the Brown & Wallerstein (1992) values except for Zr. In this study Zr has a similar enhancement ([Zr/Fe] = +0.51 dex) to another light s-process element, Y ([Y/Fe] = +0.53 dex), which reflects current theory regarding the enrichment of s-process elements by nuclear processes within AGB stars (Busso et al. 2001). This is contrary to the results of Brown & Wallerstein (1992) where Zr was under-abundant ([Zr/Fe] = +0.51 dex) and Y was over-abundant ([Y/Fe] = +0.50 dex) with respect to Fe.Comment: 11 pages, 5 figures Accepted for publication in MNRA

Dark matter in the inner parts of barred galaxies: The data

This paper presents surface photometry (B,V, I, J, H, K) and H_alpha rotation curves of 27 isolated spiral galaxies. The final goal is to obtain the mass distribution of a sample of isolated spiral galaxies in order to model their gas kinematics. This is then compared to the observed rotation curve, to determine the necessity of a dark halo in the inner parts (Perez et al. 2004). The azimuthally averaged radial surface brightness profiles and the integrated magnitudes obtained from ellipse fitting are given for each of the sample galaxies. The ellipse fitting technique applied to the light distribution also allowed us to obtain the size of the bar, and the inclination and position angle of the outer isophotes that allow the galaxy deprojection. Using these profiles, 1-D disk-bulge decomposition was performed to obtain the disk scale-length and the bulge effective radius for the different bands. Through the fitting of a parametric function to the observed rotation curve, the maximum rotational velocity and the corresponding radius was obtained. The correlation between the bulge and disk parameters is in agreement with previous studies (de Jong 1996a; Marquez & Moles 1999; Baggett et al. 1998). Regarding the Kormendy relation (Kormendy 1977), in agreement with de Jong, no correlation between the bulge effective radius and its surface brightness is found, possibly due to the small range of bulge magnitudes covered. We find a smaller scatter in the structural relations when compared to non-isolated samples in agreement with Marquez & Moles (1999). Finally, a correlation between the disk scale-length and the bar size is observed, possibly reflecting the rapid growth of a bar.Comment: A&A accepted. Fig. 11 and Tables 3-8 can be downloaded at: http://www.astro.rug.nl/~isa (they will also be available at http://www.edpsciences.org

The Shape of Dark Matter Haloes IV. The Structure of Stellar Discs in Edge-on Galaxies

We present optical and near-infrared archival observations of eight edge-on galaxies. These observations are used to model the stellar content of each galaxy using the FitSKIRT software package. Using FitSKIRT, we can self-consistently model a galaxy in each band simultaneously while treating for dust. This allows us to accurately measure both the scale length and scale height of the stellar disc, plus the shape parameters of the bulge. By combining this data with the previously reported integrated magnitudes of each galaxy, we can infer their true luminosities. We have successfully modelled seven out of the eight galaxies in our sample. We find that stellar discs can be modelled correctly, but have not been able to model the stellar bulge reliably. Our sample consists for the most part of slow rotating galaxies, and we find that the average dust layer is much thicker than what is reported for faster rotating galaxies.Comment: Accepted for publication by Monthly Notices RAS. Hi-res. version available at www.astro.rug.nl/~vdkruit/Petersetal-IV.pd

Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes

Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial. In particular, although cytosolic 5′-nucleotidases can catalyze adenosine formation in cardiomyocytes, their contribution to the actions of adenosine has not been documented previously. We recently cloned two closely related AMP-preferring cytosolic 5′-nucleotidases (cN-IA and -IB); the A form predominates in the heart. In this study, we overexpressed pigeon cN-IA in neonatal rat cardiomyocytes using an adenovirus. cN-IA overexpression increased adenosine formation and release into the medium caused by simulated hypoxia and by isoproterenol in the absence and presence of inhibitors of adenosine metabolism. Adenosine release was not affected by an ecto-5′-nucleotidase inhibitor, α,β-methylene-ADP, but was affected by a nucleoside transporter, dipyridamole. The positive chronotropic effect of isoproterenol (130 ±3 vs. 100 ±4 beats/min) was inhibited (107 ±3 vs. 94 ±3 beats/min) in cells overexpressing cN-IA, and this was reversed by the addition of the adenosine receptor antagonist 8-(p-sulfophenyl)theophilline (120 ± 3 vs. 90 ± 4 beats/min). Our results demonstrate that overexpressed cN-IA can be sufficiently active in cardiomyocytes to generate physiologically effective concentrations of adenosine at its receptors.Fil: Sala-Newby, Graciela B.. University of Bristol; Reino UnidoFil: Freeman, Nicola V. E.. University of Bristol; Reino UnidoFil: Curto, Maria de Los Angeles. University of Bristol; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Newby, Andrew C.. University of Bristol; Reino Unid

Soliton-preserving boundary condition in affine Toda field theories

We give a new integrable boundary condition in affine Toda theory which is soliton-preserving in the sense that a soliton hitting the boundary is reflected as a soliton. All previously known integrable boundary conditions forced a soliton to be converted into an antisoliton upon reflection. We prove integrability of our boundary condition using a generalization of Sklyanin's formalism.Comment: 9 page

Dynamic Animations of Journal Maps: Indicators of Structural Changes and Interdisciplinary Developments

The dynamic analysis of structural change in the organization of the sciences requires methodologically the integration of multivariate and time-series analysis. Structural change--e.g., interdisciplinary development--is often an objective of government interventions. Recent developments in multi-dimensional scaling (MDS) enable us to distinguish the stress originating in each time-slice from the stress originating from the sequencing of time-slices, and thus to locally optimize the trade-offs between these two sources of variance in the animation. Furthermore, visualization programs like Pajek and Visone allow us to show not only the positions of the nodes, but also their relational attributes like betweenness centrality. Betweenness centrality in the vector space can be considered as an indicator of interdisciplinarity. Using this indicator, the dynamics of the citation impact environments of the journals Cognitive Science, Social Networks, and Nanotechnology are animated and assessed in terms of interdisciplinarity among the disciplines involved