Black hole parameter estimation with synthetic Very Long Baseline Interferometry data from the ground and from space

The Event Horizon Telescope (EHT) has imaged the shadow of the supermassive black hole in M87. A library of general relativistic magnetohydrodynamics (GMRHD) models was fit to the observational data, providing constraints on black hole parameters. We investigate how much better future experiments can realistically constrain these parameters and test theories of gravity. We generate realistic synthetic 230 GHz data from representative input models taken from a GRMHD image library for M87, using the 2017, 2021, and an expanded EHT array. The synthetic data are run through a data reduction pipeline used by the EHT. Additionally, we simulate observations at 230, 557, and 690 GHz with the Event Horizon Imager (EHI) Space VLBI concept. Using one of the EHT parameter estimation pipelines, we fit the GRMHD library images to the synthetic data and investigate how the black hole parameter estimations are affected by different arrays and repeated observations. Repeated observations play an important role in constraining black hole and accretion parameters as the varying source structure is averaged out. A modest expansion of the EHT already leads to stronger parameter constraints. High-frequency observations from space rule out all but ~15% of the GRMHD models in our library, strongly constraining the magnetic flux and black hole spin. The 1$\sigma$ constraints on the black hole mass improve by a factor of five with repeated high-frequency space array observations as compared to observations with the current ground array. If the black hole spin, magnetization, and electron temperature distribution can be independently constrained, the shadow size for a given black hole mass can be tested to ~0.5% with the EHI, which allows tests of deviations from general relativity. High-precision tests of the Kerr metric become within reach from observations of the Galactic Center black hole Sagittarius A*.Comment: 21 pages, 18 figures, accepted for publication in Astronomy & Astrophysic

Polarimetric Geometric Modeling for mm-VLBI Observations of Black Holes

The Event Horizon Telescope (EHT) is a millimeter very long baseline interferometry (VLBI) array that has imaged the apparent shadows of the supermassive black holes M87* and Sagittarius A*. Polarimetric data from these observations contain a wealth of information on the black hole and accretion flow properties. In this work, we develop polarimetric geometric modeling methods for mm-VLBI data, focusing on approaches that fit data products with differing degrees of invariance to broad classes of calibration errors. We establish a fitting procedure using a polarimetric "m-ring" model to approximate the image structure near a black hole. By fitting this model to synthetic EHT data from general relativistic magnetohydrodynamic models, we show that the linear and circular polarization structure can be successfully approximated with relatively few model parameters. We then fit this model to EHT observations of M87* taken in 2017. In total intensity and linear polarization, the m-ring fits are consistent with previous results from imaging methods. In circular polarization, the m-ring fits indicate the presence of event-horizon-scale circular polarization structure, with a persistent dipolar asymmetry and orientation across several days. The same structure was recovered independently of observing band, used data products, and model assumptions. Despite this broad agreement, imaging methods do not produce similarly consistent results. Our circular polarization results, which imposed additional assumptions on the source structure, should thus be interpreted with some caution. Polarimetric geometric modeling provides a useful and powerful method to constrain the properties of horizon-scale polarized emission, particularly for sparse arrays like the EHT.Comment: 34 pages, 15 figures, published in The Astrophysical Journal Letter

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.National Heart, Lung, and Blood InstituteNational Institutes of Health (U.S.) (Program of Excellence in Nanotechnology (PEN) Award Contract HHSN268201000045C

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using the biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles

Studying Black Holes on Horizon Scales with VLBI Ground Arrays

High-resolution imaging of supermassive black holes is now possible, with new applications to testing general relativity and horizon-scale accretion and relativistic jet formation processes. Over the coming decade, the EHT will propose to add new strategically placed VLBI elements operating at 1.3mm and 0.87mm wavelength. In parallel, development of next-generation backend instrumentation, coupled with high throughput correlation architectures, will boost sensitivity, allowing the new stations to be of modest collecting area while still improving imaging fidelity and angular resolution. The goal of these efforts is to move from imaging static horizon scale structure to dynamic reconstructions that capture the processes of accretion and jet launching in near real time