359 research outputs found

    Challenge of Poverty to the Reformed Community

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    This article is the third in a series of three on the concept of poverty. The product of a series of seminars sponsored by the Social Sciences Division at Dordt College, the earlier articles defined poverty, introduced related Biblical concepts, and discussed the role of the state. For reference, see: Jasper Lesage, Justice for the Poor: The Political Problem of Poverties, Pro Rege (14,2: December, 1985), p. 2-15; and Maarten Vrieze, The Reformed College Confronts Poverty, Pro Rege (13,4: June, 1985), pp. 11-20

    Consumer innovation in Finland : incidence, diffusion and policy implications

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    fi=vertaisarvioimaton|en=nonPeerReviewed

    Visie op integraal advies door een financieel professional aan het mkb

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    De uitdagingen voor het mkb zijn complex, omvangrijk en hangen met elkaar samen. Om als financieel professional het mkb te kunnen faciliteren naar een toekomstbestendig perspectief, is integraal advies noodzakelijk. Dat betekent multidisciplinair adviseren over hoe zowel financiële als niet-financiële aspecten in een organisatie met elkaar samenhangen en waarde creëren. Daarbij gaat het ook over welke risico’s en kansen dit met zich meebrengt en wat de implicaties daarvan zijn voor de korte, middellange en lange termijn – zowel voor de organisatie zelf als haar omgeving, maar vooral ook in interactie met elkaar. Om integraal financieel advies te kunnen geven, zullen financieel professionals geïntegreerd moeten kunnen denken en handelen. Dat vraagt ook om een andere manier van opleiden

    Medium Effects on Binary Collisions with the Delta Resonance

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    To facilitate the relativistic heavy-ion calculations based on transport equations, the binary collisions involving a Δ\Delta resonance in either the entrance channel or the exit channel are investigated within a Hamiltonian formulation of πNN\pi NN interactions. An averaging procedure is developed to define a quasi-particle Δ∗\Delta^* and to express the experimentally measured NN→πNNNN\rightarrow \pi NN cross section in terms of an effective NN→NΔ∗NN\rightarrow N\Delta^\ast cross section. In contrast to previous works, the main feature of the present approach is that the mass and the momentum of the produced Δ∗\Delta^*'s are calculated dynamically from the bare Δ↔πN\Delta \leftrightarrow \pi N vertex interaction of the model Hamiltonian and are constrained by the unitarity condition. The procedure is then extended to define the effective cross sections for the experimentally inaccessible NΔ∗→NNN\Delta^\ast \rightarrow NN and NΔ∗→NΔ∗N\Delta^\ast \rightarrow N\Delta^\ast reactions. The predicted cross sections are significantly different from what are commonly assumed in relativistic heavy-ion calculations. The Δ\Delta potential in nuclear matter has been calculated by using a Bruckner-Hartree-Fock approximation. By including the mean-field effects on the Δ\Delta propagation, the effective cross sections of the NN→NΔ∗NN\rightarrow N\Delta^\ast, NΔ∗→NNN\Delta^\ast \rightarrow NN and NΔ∗→NΔ∗N\Delta^\ast \rightarrow N\Delta^\ast reactions in nuclear matter are predicted. It is demonstrated that the density dependence is most dramatic in the energy region close to the pion production threshold.Comment: 20 pages, RevTe

    Skeletal <sup>18</sup>F-PSMA-1007 uptake in prostate cancer patients

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    Background/objectives: Accurate and uniform interpretation and reporting of metastatic prostate cancer (PCa) lesions on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) are indispensable. 18F-PSMA-1007 is increasingly used because of its favorable imaging characteristics. However, increased non-specific skeletal uptake may be an important pitfall of this radioligand. Therefore, we aimed to assess the interobserver variation in reporting skeletal 18F-PSMA-1007 uptake on PET/CT.Design/methods: In total, 33 18F-PSMA-1007 PET/CT scans of 21 patients with primary PCa and 12 patients with biochemical recurrence were included, and a total of 85 skeletal lesions were evaluated by three independent observers. The primary endpoint was the interobserver variability of the likelihood of malignancy of the skeletal lesions on both patient and lesion level (kappa analysis).Results: Observers qualified most lesions as not malignant (81–91%) and the overall mean interobserver agreement was moderate on both patient (κ: 0.54) and lesion level (κ: 0.55). In 52 lesions without corresponding CT substrate, the rating resulted in not malignant in 95–100%. Availability of additional imaging (60% of lesions) did not improve interobserver agreement (κ: 0.39 on lesion level) and resulted in unchanged rating for all observers in 78%.Conclusion: This interobserver analysis of skeletal 18F-PSMA-1007 uptake resulted in moderate agreement, in line with rates reported in literature. Importantly, the presence of non-specific skeletal uptake without CT substrate, as a potential shortcoming of 18F-PSMA-1007, did not impair interobserver agreement.</p
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