A societal knowledge management system : harnessing indigenous wisdom to build sustainable predictors for adaptation to climate change

As the climate changes globally time-honoured climate in a region may change and shift to another region. Consequently, local predictors of climate may no longer apply to the area where they were born, but may be invaluable in new regions where previously reliable predictors have become outmoded This paper is set on the proposition thaI traditional (indigenous) know/edge can be a strategic source in adapting to climate change, in these changing times. The research reported in this paper takes the Societal Knowledge Management approach where knowledge that rests within local communities, is harnessed to inform local communities and scientists regarding climate change impacts, so as to adapt to them accurately. A phased study was conducted that aimed at acquiring, synthesising and disseminating traditional knowledge regarding change in monsoon patterns in India. Traditional wisdom prevalent among fhe myriad communities of India, was collected, collated and classified into knowledge spheres such as Bio-Indicators, Wind Movement, Atmospheric Pal/ems, Astrological Methods, Festivals and Rituals, Direction, Characteristics of the Rain, Characteristics of Celestial Bodies etc and incorporaled into a knowledge portal, which is the basis for building the Societal Knowledge Management System (SKM). Subsequently, the SKM is to be harmonised with scientific predictors on seasonal weather patterns will allow researchers to identify if the existing indicators and monsoon pattems are subject to change, and if so how. Research in progress is aimed at integrating the knowledge with modern science and disseminating this knowledge through local knowledge centres, at village levels. Furthermore, this study is to be replicated in Australia, by harnessing indigenous knowledge, to build the SKM for Australia that could assist in building a better understanding of the factors that impact the environment, methods of building sustainable predictors for climate and approaches for adapting the climate changes. The research reported is expected to inform policy makers, scientists, governance institutions as well as researchers regarding the applicability of indigenous knowledge in building sustainable predictors for adaptation to climate change in the two countries cited and can be extended into other countries.<br /

Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs

Citation: Liang, X. W., Garcia, B. L., Visai, L., Prabhakaran, S., Meenan, N. A. G., Potts, J. R., . . . Hook, M. (2016). Allosteric Regulation of Fibronectin/alpha(5)beta(1) Interaction by Fibronectin-Binding MSCRAMMs. Plos One, 11(7), 17. doi:10.1371/journal.pone.0159118Adherence ofmicrobes to host tissues is a hallmark of infectious disease and is often mediated by a class of adhesins termed MSCRAMMs (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Numerous pathogens express MSCRAMMs that specifically bind the heterodimeric human glycoprotein fibronectin (Fn). In addition to roles in adhesion, Fn-binding MSCRAMMs exploit physiological Fn functions. For example, several pathogens can invade host cells by a mechanism whereby MSCRAMM-bound Fn bridges interaction with alpha(5)beta(1) integrin. Here, we investigate two Fn-binding MSCRAMMs, FnBPA (Staphylococcus aureus) and BBK32 (Borrelia burgdorferi) to probe structure-activity relationships of MSCRAMM-induced Fn/alpha(5)beta(1) integrin activation. Circular dichroism, fluorescence resonance energy transfer, and dynamic light scattering techniques uncover a conformational rearrangement of Fn involving domains distant from the MSCRAMM binding site. Surface plasmon resonance experiments demonstrate a significant enhancement of Fn/alpha(5)beta(1) integrin affinity in the presence of FnBPA or BBK32. Detailed kinetic analysis of these interactions reveal that this change in affinity can be attributed solely to an increase in the initial Fn/alpha(5)beta(1) on-rate and that this rate-enhancement is dependent on high-affinity Fn-binding by MSCRAMMs. These data implicate MSCRAMM-induced perturbation of specific intramolecular contacts within the Fn heterodimer resulting in activation by exposing previously cryptic alpha(5)beta(1) interaction motifs. By correlating structural changes in Fn to a direct measurement of increased Fn/alpha(5)beta(1) affinity, this work significantly advances our understanding of the structural basis for the modulation of integrin function by Fn-binding MSCRAMMs

Involking silvern voices in healthcare : transforming practice by engaging older adults in collaborative partnerships

Canada's population is aging. This growing trend will ultimately have an impact on nursing practice as older individuals continue to seek healthcare services. Nurses must be able to work in collaboration with the older population to provide quality care. This action research study explored participative healthcare from an older adult's perspective. This study revealed that older adults prefer to be active participants in their care. The major theme that emerged was true partnership. Three sub-themes that emerged were communication, respect, and trust. These three sub-themes work in unity to contribute to a healthcare experience that exemplifies true partnerships. This study proposes a definition of true partnership as being open to and inviting mutual communication in an atmosphere that encourages equity sharing of information contributing to respect and the development of trust that results in confident collaboration in care