51 research outputs found
METHOD DEVELOPMENT AND OPTIMIZATION FOR MONITORING PROBE EXHALED BREATH METABOLITES USING PARALLEL MS-BASED ANALYTICAL PLATFORMS
editorial reviewe
Breath can discriminate tuberculosis from other lower respiratory illness in children
Pediatric tuberculosis (TB) remains a global health crisis. Despite progress, pediatric patients remain difficult to diagnose, with approximately half of all childhood TB patients lacking bacterial confirmation. In this pilot study (n = 31), we identify a 4-compound breathprint and subsequent machine learning model that accurately classifies children with confirmed TB (n = 10) from children with another lower respiratory tract infection (LRTI) (n = 10) with a sensitivity of 80% and specificity of 100% observed across cross validation folds. Importantly, we demonstrate that the breathprint identified an additional nine of eleven patients who had unconfirmed clinical TB and whose symptoms improved while treated for TB. While more work is necessary to validate the utility of using patient breath to diagnose pediatric TB, it shows promise as a triage instrument or paired as part of an aggregate diagnostic scheme
Bidimensional gas-chromatography (GCxGC-ToF-MS) to evaluate the volatile profile of grappa
Breath can discriminate tuberculosis from other lower respiratory illness in children.
peer reviewedPediatric tuberculosis (TB) remains a global health crisis. Despite progress, pediatric patients remain difficult to diagnose, with approximately half of all childhood TB patients lacking bacterial confirmation. In this pilot study (n = 31), we identify a 4-compound breathprint and subsequent machine learning model that accurately classifies children with confirmed TB (n = 10) from children with another lower respiratory tract infection (LRTI) (n = 10) with a sensitivity of 80% and specificity of 100% observed across cross validation folds. Importantly, we demonstrate that the breathprint identified an additional nine of eleven patients who had unconfirmed clinical TB and whose symptoms improved while treated for TB. While more work is necessary to validate the utility of using patient breath to diagnose pediatric TB, it shows promise as a triage instrument or paired as part of an aggregate diagnostic scheme
30th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances
In this review, we report on the latest (2020-Early 2021) instrumental advances and applications of comprehensive two-dimensional gas chromatography (GC×GC), including its hyphenation with novel upstream or downstream processes (sample preparation approaches or detection technologies). We also discuss software and analysis workflow developments necessary to elaborate the dense chemical information obtained. Thirty years after its inception, the use of GC×GC, as the main analytical tool or as a complementary platform, is undoubtedly shifting toward more applied challenges in a vast breadth of applications. Therefore, we consider the major fields (energy, fuel, foodstuff, plant, biological, and environmental) in which GC×GC has been successfully used, discussing some of the recent innovative research works
GC multidimensionale “comprehensive” con modulazione a flusso: è questo il futuro delle separazioni GC ad alta risoluzione?
Low-flow modulation comprehensive 2D GC-high resolution ToF MS: a powerful tool for untargeted, pre- and post-targeted analysis
Concept of (low-)flow modulation comprehensive two-dimensional gas chromatography under sub-ambient, ambient and supra-ambient pressure outlet conditions
Comprehensive 2D GC combined with novel MS instrumentation: powerful unified tools for the analysis of complex samples
Potential of Comprehensive Two-Dimensional Gas Chromatography for the Analysis of Lipids
The field of lipid analysis is an extremely important area of research in food chemistry; such
importance is related to the fundamental biological functions of lipids such as structural components of cell membranes, energy storage
compounds, signaling molecules, etc. From a
human nutritional viewpoint, oils and fats provide
not only energy but also essential fatty acids,
polyunsaturated fatty acids (PUFAs), sterols, and
vitamins. Additionally, lipids play a crucial role in
human health; in fact, a number of disease states
are related to an excessive or unbalanced lipid
consumptio
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