Publication and patent analysis of European researchers in the field of production technology and manufacturing systems

This paper develops a structured comparison among a sample of European researchers in the field of Production Technology and Manufacturing Systems, on the basis of scientific publications and patents. Researchers are evaluated and compared by a variegated set of indicators concerning (1) the output of individual researchers and (2) that of groups of researchers from the same country. While not claiming to be exhaustive, the results of this preliminary study provide a rough indication of the publishing and patenting activity of researchers in the field of interest, identifying (dis)similarities between different countries. Of particular interest is a proposal for aggregating analysis results by means of maps based on publication and patent indicators. A large amount of empirical data are presented and discusse

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis

Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experimental models of spinal and brain injury and Alzheimer disease, as well as a clinical improvement in human stroke patients. Furthermore, PEALut enhances the expression of different myelin proteins in oligodendrocyte progenitor cells suggesting that this composite might have protective effects in MS experimental models. Methods: The mouse model of experimental autoimmune encephalomyelitis (EAE) based on active immunization with a fragment of myelin oligodendrocyte glycoprotein (MOG35-55) was used. The daily assessment of clinical score and the expression of serum amyloid A (SAA1), proinflammatory cytokines TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 inflammasome, as well as TLR2, Fpr2, CD137, CD3-\u3b3, and TCR-\u3b6 chain, heterodimers that form T cell surface glycoprotein (TCR), and cannabinoid receptors CB1, CB2, and MBP, were evaluated in the brainstem and cerebellum at different postimmunization days (PIDs). Results: Vehicle-MOG35-55-immunized (MOG35-55) mice developed ascending paralysis which peaked several days later and persisted until the end of the experiment. PEALut, given intraperitoneally daily starting on day 11 post-immunization, dose-dependently improved clinical score over the range 0.1-5 mg/kg. The mRNA expression of SAA1, TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 were significantly increased in MOG35-55 mice at 14 PID. In MOG35-55 mice treated with 5 mg /kg PEALut, the increase of SAA1, TNF- \u3b1, IL-1\u3b2, and IFN-\u3b3transcripts at 14 PID was statistically downregulated as compared to vehicle-MOG35-55 mice (p < 0.05). The expression of TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 receptors showed a significant upregulation in vehicle-MOG35-55 mice at 14 PID. Instead, CB1 and MBP transcripts have not changed in expression at any time. In MOG/PEALut-treated mice, TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 mRNAs were significantly downregulated as compared to vehicle MOG35-55 mice. Conclusions: The present results demonstrate that the intraperitoneal administration of the composite PEALut significantly reduces the development of clinical signs in the MOG35-55 model of EAE. The dose-dependent improvement of clinical score induced by PEALut was associated with a reduction in transcript expression of the acute-phase protein SAA1, TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 proinflammatory proteins and TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 receptors

The success-index: an alternative approach to the h-index for evaluating an individual's research output

Among the most recent bibliometric indicators for normalizing the differences among fields of science in terms of citation behaviour, Kosmulski (J Informetr 5(3):481-485, 2011) proposed the NSP (number of successful paper) index. According to the authors, NSP deserves much attention for its great simplicity and immediate meaning— equivalent to those of the h-index—while it has the disadvantage of being prone to manipulation and not very efficient in terms of statistical significance. In the first part of the paper, we introduce the success-index, aimed at reducing the NSP-index's limitations, although requiring more computing effort. Next, we present a detailed analysis of the success-index from the point of view of its operational properties and a comparison with the h-index's ones. Particularly interesting is the examination of the success-index scale of measurement, which is much richer than the h-index's. This makes success-index much more versatile for different types of analysis—e.g., (cross-field) comparisons of the scientific output of (1) individual researchers, (2) researchers with different seniority, (3) research institutions of different size, (4) scientific journals, etc

Extragalactic Source Counts and Contributions to the Anisotropies of the Cosmic Microwave Background. Predictions for the Planck Surveyor mission

We present predictions for the counts of extragalactic sources, the contributions to fluctuations and their spatial power spectrum in each channel foreseen for the Planck Surveyor (formerly COBRAS/SAMBA) mission. The contribution to fluctuations due to clustering of both radio and far--IR sources is found to be generally small in comparison with the Poisson term; however the relative importance of the clustering contribution increases and may eventually become dominant if sources are identified and subtracted down to faint flux limits. The central Planck frequency bands are expected to be ``clean'': at high galactic latitude (|b|>20), where the reduced galactic noise does not prevent the detection of the extragalactic signal, only a tiny fraction of pixels is found to be contaminated by discrete extragalactic sources. Moreover, removal of contaminating signals is eased by the substantial difference between their power spectrum and that of primordial fluctuations.Comment: 10 pages, Latex, mn.sty, 8 figures included, MNRAS, in the press. Minor changes in the text. Sections 3.1 and 3.2 have been expanded. Source counts in Table 2 have been slightly changed. Figure 1,2,7 and 8 have been replaced by new version

The detection and photometric redshift determination of distant galaxies using SIRTF's Infrared Array Camera

We investigate the ability of the Space Infrared Telescope Facility's Infrared Array Camera to detect distant (z ~ 3)galaxies and measure their photometric redshifts. Our analysis shows that changing the original long wavelength filter specifications provides significant improvements in performance in this and other areas.Comment: 28 pages incl 12 figures; to appear in June 1999 PASP. Fig.12 replaced with corrected versio

Cosmological evolution of extragalactic sources in the infrared and contributions to the background radiation

Infrared surveys provide essential insights on galaxy evolution. If near-IR studies suggest a mild evolution of stellar populations with cosmic time, indications of a substantial evolution have been seen in the far IR, although the available information is largely insufficient to delineate precise evolutionary properties. A consistent picture encompassing all the currently available data may be obtained assuming that dust extinction hides the early evolutionary phases of spheroidal galaxies in the optical band, while the corresponding dust re-radiation in the far IR may have been, during the early evolutionary phases, orders of magnitude larger than today. Hyperluminous IRAS galaxies might be extreme examples of this situation. Additional indications that at least some spheroidal galaxiesmay have been very dusty during their early evolution are provided by recent data on high redshift radio galaxies and quasars. Galaxies are the likely dominant contributors to the IR background. However, in the framework of unified models for Active Galactic Nuclei, a large number of nuclei hidden by a dusty torus may be expected. Implications for the IR background are discussed

A New Method for ISOCAM Data Reduction - I. Application to the European Large Area ISO Survey Southern Field: Method and Results

We have developed a new data reduction technique for ISOCAM LW data and have applied it to the European Large Area ISO Survey (ELAIS) LW3 (15 micron) observations in the southern hemisphere (S1). This method, known as LARI technique and based on the assumption of the existence of two different time scales in ISOCAM transients (accounting either for fast or slow detector response), was particularly designed for the detection of faint sources. In the ELAIS S1 field we obtained a catalogue of 462 15 micron sources with signal-to-noise ratio >= 5 and flux densities in the range 0.45 - 150 mJy (filling the whole flux range between the Deep ISOCAM Surveys and the IRAS Faint Source Survey). The completeness at different flux levels and the photometric accuracy of this catalogue have been tested with simulations. Here we present a detailed description of the method and discuss the results obtained by its application to the S1 LW3 data.Comment: 20 pages, LaTeX, MNRAS style, 20 postscript figures, full catalogue not yet available at http://boas5.bo.astro.it/~elais/catalogues/. Accepted for publication in MNRA