1,523 research outputs found
Outcome from Spontaneous CP Violation for B Decays
In the aspon model solution of the strong problem, there is a gauged
symmetry, spontaneously broken by the same vacuum expectation value
which breaks , whose massive gauge boson provides an additional mechanism
of weak violation. We calculate the asymmetries in decays for the
aspon model and show that they are typically smaller than those predicted from
the standard model. A linear relation between the asymmetries of different
decay processes is obtained.Comment: REVTEX, 9 pages, IFP-486-UNC, NSF-PT-94-1, and UDHEP-01-9
Eliminating the low-mass axigluon window
Using recent collider data, especially on the hadronic width the Z0, we
exclude axigluons in the currently allowed low-mass window, namely axigluons in
the mass range 50 GeV < M_A < 120 GeV. Combined with hadron collider data from
di-jet production, axigluons with masses below roughly 1 TeV are now completely
excluded.Comment: 8 pages, no figures, LaTe
Horizontal Symmetry for Quark and Squark Masses in Supersymmetric SU(5)
Recent interest in horizontal symmetry model building has been driven mainly
by the large top mass and hence strong hierarchy in quark masses, and the
possibility of appropriately constrained soft squark mass matrices, in place of
an assumed universality condition, for satisfying the relevant FCNC
constraints. Here we present the first successful SUSY- model that has
such a feature. The horizontal symmetry is a gauged
(). All nonrenormalizable terms compatible with
the symmetry are allowed in the mass matrix constructions. Charged lepton
masses can also be accommodated.Comment: 15 pages, latex, 1 latex figure included version to be published in
Phys. Rev. Lett. ; some small changes in notations and presentation, a small
paragragh and 3 references adde
Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Background: Squamous cell carcinomas (SCC) have diverse anatomic etiologies but may share common genomic biomarkers. We profiled 7,871 unique SCCs across nine anatomic sites to investigate commonality in genomic alterations (GA), tumor mutational burden (TMB), human papillomavirus (HPV) association, and mutational signatures.
Methods: Tissue from over 8,100 unique SCC samples originating from nine anatomic sites (anogenital (anus, cervix, penis, vagina, vulva), esophagus, head and neck, lung, and skin) were sequenced by hybrid capture-based comprehensive genomic profiling to evaluate GA and TMB. About 3% of non-cutaneous SCC samples had UV signatures, indicative of potential primary site misdiagnoses, and were filtered from the analysis. Detection of HPV, including high-risk strains 16, 18, 31, 33, and 45, was implemented through de novo assembly of non-human sequencing reads and BLASTn comparison against all viral nucleotide sequences in the NCBI database.
Results: The proportion of HPV+ patients by anatomic site varied, with the highest being anal (91%) and cervical (83%). The mutational landscape of each cohort was similar, regardless of anatomic origin, but clustered based on HPV status. The largest differences in GA frequency as stratified by HPV- vs. HPV+ were TP53 (87% vs. 12%), CDKN2A (45% vs. 6%), and PIK3CA (22% vs. 33%). The median TMB in cases originating from HPV-associated sites was similar, regardless of HPV status. Higher median TMB was observed in lung and skin cases, which exhibited significant enrichment of mutational signatures indicative of tobacco- and UV-induced DNA damage, respectively.
Conclusions: HPV+ and HPV- SCC populations have distinct genomic profiles and, for the latter, anatomic site is correlated with TMB distribution, secondary to associated carcinogen exposure. As such, biomarkers such as TMB and UV signature can provide unexpected insight into site of origin misdiagnoses and may correlate with benefit from immune checkpoint inhibitors
Gluon mass generation without seagull divergences
Dynamical gluon mass generation has been traditionally plagued with seagull
divergences, and all regularization procedures proposed over the years yield
finite but scheme-dependent gluon masses. In this work we show how such
divergences can be eliminated completely by virtue of a characteristic
identity, valid in dimensional regularization. The ability to trigger the
aforementioned identity hinges crucially on the particular Ansatz employed for
the three-gluon vertex entering into the Schwinger-Dyson equation governing the
gluon propagator. The use of the appropriate three-gluon vertex brings about an
additional advantage: one obtains two separate (but coupled) integral
equations, one for the effective charge and one for the gluon mass. This system
of integral equations has a unique solution, which unambiguously determines
these two quantities. Most notably, the effective charge freezes in the
infrared, and the gluon mass displays power-law running in the ultraviolet, in
agreement with earlier considerations.Comment: 37 pages, 9 figures; minor typos corrected and a few brief
explanatory remarks adde
Aspects of Type 0 String Theory
A construction of compact tachyon-free orientifolds of the non-supersymmetric
Type 0B string theory is presented. Moreover, we study effective
non-supersymmetric gauge theories arising on self-dual D3-branes in Type 0B
orbifolds and orientifolds.Comment: 9 pages, LATEX; submitted to Proceedings of Strings '9
Comment on ``Majoron emitting neutrinoless double beta decay in the electroweak chiral gauge extensions''
We point out that if the majoron-like scheme is implemented within a 331
model, there must exist at least three different mass scales for the scalar
vacuum expectation values in the model.Comment: 4 pages, no figures, Revtex. To be published in Physical Review
Neutrino-Lepton Masses, Zee Scalars and Muon g-2
Evidence for neutrino oscillations is pointing to the existence of tiny but
finite neutrino masses. Such masses may be naturally generated via radiative
corrections in models such as the Zee model where a singlet Zee-scalar plays a
key role. We minimally extend the Zee model by including a right-handed singlet
neutrino \nu_R. The radiative Zee-mechanism can be protected by a simple U(1)_X
symmetry involving only the \nu_R and a Zee-scalar. We further construct a
class of models with a single horizontal U(1)_FN (a la Frogatt-Nielsen) such
that the mass patterns of the neutrinos and leptons are naturally explained. We
then analyze the muon anomalous magnetic moment (g-2) and the flavor changing
\mu --> e\gamma decay. The \nu_R interaction in our minimal extension is found
to induce the BNL g-2 anomaly, with a light charged Zee-scalar of mass 100-300
GeV.Comment: Version for Phys. Rev. Lett. (typos corrected, minor refinements
Beta Functions of Orbifold Theories and the Hierarchy Problem
We examine a class of gauge theories obtained by projecting out certain
fields from an N=4 supersymmetric SU(N) gauge theory. These theories are
non-supersymmetric and in the large N limit are known to be conformal. Recently
it was proposed that the hierarchy problem could be solved by embedding the
standard model in a theory of this kind with finite N. In order to check this
claim one must find the conformal points of the theory. To do this we calculate
the one-loop beta functions for the Yukawa and quartic scalar couplings. We
find that with the beta functions set to zero the one-loop quadratic
divergences are not canceled at sub-leading order in N; thus the hierarchy
between the weak scale and the Planck scale is not stabilized unless N is of
the order 10^28 or larger. We also find that at sub-leading orders in N
renormalization induces new interactions, which were not present in the
original Lagrangian.Comment: 21 pages, LaTeX, 6 figures. Minor clarifications, references adde
S, T, U parameters in model with right-handed neutrinos
The S, T, U parameters in the model with
right -handed neutrinos are calculated. Explicit expressions for the oblique
and Z - Z' mixing contributions are obtained. We show that the bilepton oblique
contributions to S and T parameters are bounded : and . The Z - Z' mixing contribution is positive and above 10%, but it will
increase fastly with the higher Z' mass. %can be negative. The consequent mass
splitting of the bilepton is derived and to be 15%. The limit on the mass of
the neutral bilepton in this model is obtained.Comment: Latex, axodraw.sty used, 3 figures, 18 page
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