25,829 research outputs found
Experimental data on wind-induced vibrations of a paraboloidal reflector antenna model
Experimental data on wind induced vibrations of paraboloidal reflector antenna mode
The health and sport engagement (HASE) intervention and evaluation project: protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity.
INTRODUCTION: Sport is being promoted to raise population levels of physical activity for health. National sport participation policy focuses on complex community provision tailored to diverse local users. Few quality research studies exist that examine the role of community sport interventions in raising physical activity levels and no research to date has examined the costs and cost-effectiveness of such provision. This study is a protocol for the design, outcome, process and economic evaluation of a complex community sport intervention to increase levels of physical activity, the Health and Sport Engagement (HASE) project part of the national Get Healthy Get Active programme led by Sport England. METHODS AND ANALYSIS: The HASE study is a collaborative partnership between local community sport deliverers and sport and public health researchers. It involves designing, delivering and evaluating community sport interventions. The aim is to engage previously inactive people in sustained sporting activity for 1×30 min a week and to examine associated health and well-being outcomes. The study uses mixed methods. Outcomes (physical activity, health, well-being costs to individuals) will be measured by a series of self-report questionnaires and attendance data and evaluated using interrupted time series analysis controlling for a range of sociodemographic factors. Resource use will be identified and measured using diaries, interviews and records and presented alongside effectiveness data as incremental cost-effectiveness ratios and cost-effectiveness acceptability curves. A longitudinal process evaluation (focus groups, structured observations, in-depth interview methods) will examine the efficacy of the project for achieving its aim using the principles of thematic analysis. ETHICS AND DISSEMINATION: The results of this study will be disseminated through peer-reviewed publications, academic conference presentations, Sport England and national public health organisation policy conferences, and practice-based case studies. Ethical approval was obtained through Brunel University London's research ethics committee (reference number RE33-12)
Load distributions on the surface of para- boloidal reflector antennas
Load distributions on paraboloidal reflector antenna surfaces in wind tunnel tes
Tectonics of the central Andes
Acquisition of nearly complete coverage of Thematic Mapper data for the central Andes between about 15 to 34 degrees S has stimulated a comprehensive and unprecedented study of the interaction of tectonics and climate in a young and actively developing major continental mountain belt. The current state of the synoptic mapping of key physiographic, tectonic, and climatic indicators of the dynamics of the mountain/climate system are briefly reviewed
Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort
Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications.
Objectives: To directly compare the efficacy of all currently available osteoporosis medications by using a large population claims database.
Methods: The Truven Health Analytics MarketScan® database from 2008 - 2012 was used to identify all patients who started a new osteoporosis medication. Patients who experienced a fracture after at least 12 months of treatment were identified and risk factors for fracture for all patients were recorded. Logistic regression was used to account for and quantify the contribution of risk factors, and to make direct comparisons between different osteoporosis medications.
Results: A total of 51649 patients were included in the cohort, with an average age of 56 years. The overall incidence rate of fracture was 1.55 per 100 person - years of treatment. Orally administered medications had the lowest fracture rates, led by raloxifene and alendronate (1.24 and 1.54 respectively), while parenterally administered medications including teriparatide and zolerdonic acid had the highest rates (3.90 and 1.98 respectively). No statistically significant differences found between oral or parenterally administered bisphosphonate medications.
Conclusions: While patients taking orally administered drugs including bisphosphonates had less frequent incident fracture no statistically significant differences were found between most drugs in head - to - head comparisons, even considering the route of administration of bisphosphonates. These findings support previous evidence that minimal differences in efficacy exist between different osteoporosis medications. This is the first study using a large database to compare all currently available osteoporosis treatments and will hopefully be augmented by further study to provide more evidence to make clinical decisions on osteoporosis medication use.
© 2017 American Association of Neuropathologists, Inc
Bounds for graph regularity and removal lemmas
We show, for any positive integer k, that there exists a graph in which any
equitable partition of its vertices into k parts has at least ck^2/\log^* k
pairs of parts which are not \epsilon-regular, where c,\epsilon>0 are absolute
constants. This bound is tight up to the constant c and addresses a question of
Gowers on the number of irregular pairs in Szemer\'edi's regularity lemma.
In order to gain some control over irregular pairs, another regularity lemma,
known as the strong regularity lemma, was developed by Alon, Fischer,
Krivelevich, and Szegedy. For this lemma, we prove a lower bound of
wowzer-type, which is one level higher in the Ackermann hierarchy than the
tower function, on the number of parts in the strong regularity lemma,
essentially matching the upper bound. On the other hand, for the induced graph
removal lemma, the standard application of the strong regularity lemma, we find
a different proof which yields a tower-type bound.
We also discuss bounds on several related regularity lemmas, including the
weak regularity lemma of Frieze and Kannan and the recently established regular
approximation theorem. In particular, we show that a weak partition with
approximation parameter \epsilon may require as many as
2^{\Omega(\epsilon^{-2})} parts. This is tight up to the implied constant and
solves a problem studied by Lov\'asz and Szegedy.Comment: 62 page
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