Neuronal networks in the developing brain are adversely modulated by early psychosocial neglect

The brain's neural circuitry plays a ubiquitous role across domains in cognitive processing and undergoes extensive re-organization during the course of development in part as a result of experience. In this paper we investigated the effects of profound early psychosocial neglect associated with institutional rearing on the development of task-independent brain networks, estimated from longitudinally acquired electroencephalographic (EEG) data from <30 to 96 months, in three cohorts of children from the Bucharest Early Intervention Project (BEIP), including abandoned children reared in institutions who were randomly assigned either to a foster care intervention or to remain in care as usual and never institutionalized children. Two aberrantly connected brain networks were identified in children that had been reared in institutions: 1) a hyper-connected parieto-occipital network, which included cortical hubs and connections that may partially overlap with default-mode network and 2) a hypo-connected network between left temporal and distributed bilateral regions, both of which were aberrantly connected across neural oscillations. This study provides the first evidence of the adverse effects of early psychosocial neglect on the wiring of the developing brain. Given these networks' potentially significant role in various cognitive processes, including memory, learning, social communication and language, these findings suggest that institutionalization in early life may profoundly impact the neural correlates underlying multiple cognitive domains, in ways that may not be fully reversible in the short term

Synchronous dynamics of zooplankton competitors prevail in temperate lake ecosystems

Although competing species are expected to exhibit compensatory dynamics (negative temporal covariation), empirical work has demonstrated that competitive communities often exhibit synchronous dynamics (positive temporal covariation). This has led to the suggestion that environmental forcing dominates species dynamics; however, synchronous and compensatory dynamics may appear at different length scales and/or at different times, making it challenging to identify their relative importance. We compiled 58 long-term datasets of zooplankton abundance in north-temperate and sub-tropical lakes and used wavelet analysis to quantify general patterns in the times and scales at which synchronous/compensatory dynamics dominated zooplankton communities in different regions and across the entire dataset. Synchronous dynamics were far more prevalent at all scales and times and were ubiquitous at the annual scale. Although we found compensatory dynamics in approximately 14% of all combinations of time period/scale/lake, there were no consistent scales or time periods during which compensatory dynamics were apparent across different regions. Our results suggest that the processes driving compensatory dynamics may be local in their extent, while those generating synchronous dynamics operate at much larger scales. This highlights an important gap in our understanding of the interaction between environmental and biotic forces that structure communities

Analysing passengers' behaviours when boarding trains to improve rail infrastructure and technology

Concentrated boarding describes the phenomenon when rail passengers congregate in certain areas of the platform and board the train carriages that stop near these areas. This influences the distribution of passengers throughout the carriages, which can negatively affect passenger comfort, safety at the platform-train interface, efficiency of the rail network, and the reputation of rail travel as a whole. This project aimed to determine whether concentrated boarding occurs in stations in the UK in order to understand its relevance for future rolling stock, infrastructure design and its associated manufacturing research. Video recording technology was used to observe the movements of passengers in Oxford Station and data was collected for nine individual trains. By reviewing the recordings, the number of passengers boarding through each door of the trains was determined, and the boarding distribution along the length of the platform was plotted. Several reasons for noted trends are offered, and potential solutions proposed. The use of real time information could be invaluable to minimise concentrated boarding, as it would allow passengers to make informed decisions as to where they could board trains to have a better journey experience. These findings indicate the relevance of a human-centred design process, particularly the user research stages, in the process of defining priorities for manufacturing and engineering

Medical genetics and epigenetics of telomerase

Telomerase is a specialized reverse transcriptase that extends and maintains the terminal ends of chromosomes, or telomeres. Since its discovery in 1985 by Nobel Laureates Elizabeth Blackburn and Carol Greider, thousands of articles have emerged detailing its significance in telomere function and cell survival. This review provides a current assessment on the importance of telomerase regulation and relates it in terms of medical genetics. In this review, we discuss the recent findings on telomerase regulation, focusing on epigenetics and non-coding RNAs regulation of telomerase, such as microRNAs and the recently discovered telomeric-repeat containing RNA transcripts. Human genetic disorders that develop due to mutations in telomerase subunits, the role of single nucleotide polymorphisms in genes encoding telomerase components and diseases as a result of telomerase regulation going awry are also discussed. Continual investigation of the complex regulation of telomerase will further our insight into the use of controlling telomerase activity in medicine

"Post-GDM support would be really good for mothers": A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes.

BACKGROUND: Women with a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mellitus (T2DM). They are therefore recommended to follow a healthy diet and be physically active in order to reduce that risk. However, achieving and maintaining these behaviours in the postpartum period is challenging. This study sought to explore women's views on suggested practical approaches to achieve and maintain a healthy diet and physical activity to reduce T2DM risk. METHODS: Semi-structured interviews with 20 participants in Cambridgeshire, UK were conducted at three to 48 months after GDM. The participants' current diet and physical activity, intentions for any changes, and views on potential interventions to help manage T2DM risk through these behaviours were discussed. Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions, and thematic framework were based on a recent systematic review. RESULTS: Most of the participants wanted to eat more healthily and be more active. A third of the participants considered that postpartum support for these behaviours would be transformative, a third thought it would be beneficial, and a third did not want additional support. The majority agreed that more information about the impact of diet and physical activity on diabetes risk, support to exercise with others, and advice about eating healthily, exercising with a busy schedule, monitoring progress and sustaining changes would facilitate a healthy diet and physical activity. Four other suggested interventions received mixed responses. It would be acceptable for this support to be delivered throughout pregnancy and postpartum through a range of formats. Clinicians were seen to have important roles in giving or signposting to support. CONCLUSIONS: Many women would appreciate more support to reduce their T2DM risk after GDM and believe that a variety of interventions to integrate changes into their daily lives would help them to sustain healthier lifestyles.RAD was funded by a PhD studentship from the National Institute for Health Research (NIHR) School for Primary Care Research (SPCR; SPCR-S-S102). This paper presents independent research funded by the NIHR SPCR. The views expressed are those of the author(s) and not necessarily those of the NIHR, the NHS or the Department of Health. JAUS was funded by a Cancer Research UK Cancer Prevention Fellowship (C55650/A21464). SJG is supported by the Medical Research Council (MC_UU_12015/4). The University of Cambridge has received salary support in respect of SJG from the NHS in the East of England through the Clinical Academic Reserve. CEA is supported by an Action Medical Research Grant (GN2778) and a Medical Research Council New Investigator Research Grant (MR/T016701/1). CLM is supported by the Diabetes UK Harry Keen Intermediate Clinical Fellowship (DUK-HKF 17/0005712) and the European Foundation for the Study of Diabetes – Novo Nordisk Foundation Future Leaders’ Award (NNF19SA058974). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Effect of Early Institutionalization and Foster Care on Long-term White Matter Development

IMPORTANCE: Severe neglect in early life is associated with compromises in brain development and associated behavioral functioning. Although early intervention has been shown to support more normative trajectories of brain development, specific improvements in the white matter pathways that underlie emotional and cognitive development are unknown. OBJECTIVE: To examine associations among neglect in early life, early intervention, and the microstructural integrity of white matter pathways in middle childhood. DESIGN, SETTING, AND PARTICIPANTS: The Bucharest Early Intervention Project is a randomized clinical trial of high-quality foster care as an intervention for institutionally reared children in Bucharest, Romania, from 2000 through the present. During infancy, children were randomly selected to remain in an institution or to be placed in foster care. Those who remained in institutions experienced neglect, including social, emotional, linguistic, and cognitive impoverishment. Developmental trajectories of these children were compared with a group of sociodemographically matched children reared in biological families at baseline and several points throughout development. At approximately 8 years of age, 69 of the original 136 children underwent structural magnetic resonance imaging scans. MAIN OUTCOMES AND MEASURES: Four estimates of white matter integrity (fractional anisotropy [FA] and mean [MD], radial [RD], and axial [AD] diffusivity) for 48 white matter tracts throughout the brain were obtained through diffusion tensor imaging. RESULTS: Significant associations emerged between neglect in early life and microstructural integrity of the body of the corpus callosum (FA, β = 0.01 [P = .01]; RD, β = -0.02 [P = .005]; MD, β = -0.01 [P = .02]) and tracts involved in limbic circuitry (fornix crus [AD, β = 0.02 (P = .046)] and cingulum [RD, β = -0.01 (P = .02); MD, β = -0.01 (P = .049)]), frontostriatal circuitry (anterior [AD, β = -0.01 (P = .02)] and superior [AD, β = -0.02 (P = .02); MD, β = -0.01 (P = .03)] corona radiata and external capsule [right FA, β = 0.01 (P = .03); left FA, β = 0.01 (P = .03); RD, β = -0.01 (P = .01); MD, β = -0.01 (P = .03)]), and sensory processing (medial lemniscus [AD, β = -0.02 (P = .045); MD, β = -0.01 (P = .04)] and retrolenticular internal capsule [FA, β = -0.01 (P = .002); RD, β = 0.01 (P = .003); MD, β = 0.01 (P = .04)]). Follow-up analyses revealed that early intervention promoted more normative white matter development among previously neglected children who entered foster care. CONCLUSIONS AND RELEVANCE: Results suggest that removal from conditions of neglect in early life and entry into a high-quality family environment can support more normative trajectories of white matter growth. Our findings have implications for public health and policy efforts designed to promote normative brain development among vulnerable children

Integrated Spacecraft Autonomous Attitude Control (ISAAC)

The purpose of this project is to give undergraduate students an opportunity to design, manufacture, and maintain a mock spacecraft to be used as a testbed for autonomous control systems. The spacecraft is based on two previous models: the JX-01, an undergraduate built testbed, and the Asteroid Free Flyer led by NASA engineer and ERAU doctoral student, Michael Dupuis. This model includes cable improvements, Inertial Measurement Units (IMU), Light Detection and Ranging (LIDAR), and object-based state estimation to improve control stabilization. When completed, the hardware built for this project will provide undergraduates and researchers a platform with which they can test control algorithms and spacecraft component design. The results gathered from the project thus far is the building and design and controls experience between the team. After completion we will be able to obtain a properly modeled control algorithm and test it against multiple conditions. The final goal of the spacecraft is to provide the capabilities and perform experiments to test multiple methods to mitigate the effects of internal and external forces such as fuel sloshing, solar radiation, debris collision, and CG change

Photon Statistics of Filtered Resonance Fluorescence

Spectral filtering of resonance fluorescence is widely employed to improve single photon purity and indistinguishability by removing unwanted backgrounds. For filter bandwidths approaching the emitter linewidth, complex behaviour is predicted due to preferential transmission of components with differing photon statistics. We probe this regime using a Purcell-enhanced quantum dot in both weak and strong excitation limits, finding excellent agreement with an extended sensor theory model. By changing only the filter width, the photon statistics can be transformed between antibunched, bunched, or Poissonian. Our results verify that strong antibunching and a sub-natural linewidth cannot simultaneously be observed, providing new insight into the nature of coherent scattering.Comment: Main manuscript 7 pages with 4 figures, supplementary material of 4 page

Integrated Spacecraft Autonomous Attitude Control (ISAAC)

The purpose of this project is to give undergraduate students an opportunity to design, manufacture, and maintain a mock spacecraft to be used as a testbed for autonomous control systems. The spacecraft is based on two previous models: the JX-01, an undergraduate built testbed, and the Asteroid Free Flyer led by NASA engineer and ERAU doctoral student, Michael Dupuis. This model includes cable improvements, Inertial Measurement Units (IMU), Light Detection and Ranging (LIDAR), and object-based state estimation to improve control stabilization. When completed, the hardware built for this project will provide undergraduates and researchers a platform with which they can test control algorithms and spacecraft component design. The results gathered from the project thus far is the building and design and controls experience between the team. After completion we will be able to obtain a properly modeled control algorithm and test it against multiple conditions. The final goal of the spacecraft is to provide the capabilities and perform experiments to test multiple methods to mitigate the effects of internal and external forces such as fuel sloshing, solar radiation, debris collision, and CG change

‘Oh, I’ve got an appointment’: A qualitative interview study exploring how to support attendance at diabetes screening after gestational diabetes

Funder: NIHR School for Primary Care Research; Id: http://dx.doi.org/10.13039/501100013374Funder: Cancer Research UK; Id: http://dx.doi.org/10.13039/501100000289Funder: Action Medical Research; Id: http://dx.doi.org/10.13039/501100000317Funder: European Foundation for the Study of Diabetes; Id: http://dx.doi.org/10.13039/501100001648Funder: Medical Research Council; Id: http://dx.doi.org/10.13039/501100000265Funder: Diabetes UK; Id: http://dx.doi.org/10.13039/501100000361Abstract: Aims: To explore the views of women with a history of gestational diabetes mellitus (GDM) on suggested practical approaches to support diabetes screening attendance after GDM, which is recommended but poorly attended. Methods: We conducted semi‐structured interviews with 20 participants in Cambridgeshire, UK who had been diagnosed with GDM and were 3–48 months postpartum. Interviews covered whether participants had been screened and why, plans for future screening and their views on potential interventions to facilitate attendance (at the first postpartum test and annual testing). Framework analysis was used to analyse the transcripts. The interview schedule, suggested interventions and thematic framework were based on a recent systematic review. Results: Sixteen participants had undergone screening since pregnancy, explaining that they had an appointment arranged and wanted reassurance that they did not have diabetes. The participants who had not been tested were not aware that it was recommended. Only 13 had planned to attend subsequent tests at the start of the interview. Eight themes to support future attendance were discussed. The majority of the participants agreed that changing the processes for arranging tests, offering choice in test location and combining appointments would facilitate attendance. Child‐friendly clinics, more opportunities to understand GDM and the role of postpartum testing, stopping self‐testing and increasing their GP’s awareness of their pregnancy received inconsistent feedback. The nature of the test used did not appear to influence attendance. Conclusions: The participants wanted to be screened for diabetes after GDM. We have identified interventions that could be relatively simply incorporated into routine practice to facilitate screening attendance, such as flexibility in the appointment location or time and sending invitations for tests