Aspects of UGT2B15 in the human

No abstract available

Estimation of bearing contact angle in-situ by X-ray kinematography

The mounted, preloaded contact angle of the structural bearings in the assembled design mechanical assembly was measured. A modification of the Turns method is presented, based upon the clarity and definition of moving parts achieved with X-ray technique and cinematic display. Contact angle is estimated by counting the number of bearings passing a given point as a function of number of turns of the shaft. Ball and pitch diameter variations are discussed. Ball train and shaft angle uncertainties are also discussed

Intermittency in the transition to turbulence

It is commonly known that the intermittent transition from laminar to turbulent flow in pipes occurs because, at intermediate values of a prescribed pressure drop, a purely laminar flow offers too little resistance, but a fully turbulent one offers too much. We propose a phenomenological model of the flow, which is able to explain this in a quantitative way through a hysteretic transition between laminar and turbulent states, characterized by a disturbance amplitude variable that satisfies a natural type of evolution equation. The form of this equation is motivated by physical observations and derived by an averaging procedure, and we show that it naturally predicts disturbances having the characteristics of slugs and puffs. The model predicts oscillations similar to those which occur in intermittency in pipe flow, but it also predicts that stationary biphasic states can occur in sufficiently short pipes

Periodic breathing at high altitude.

Periodic breathing is often associated with heart disease or stroke, and commonly Cheyne-Stokes breathing has a period of about a minute. Periodic breathing also commonly occurs in healthy subjects at high altitude, and here the periods may be much shorter, of the order of 15-20 s. In this paper we study such periodic breathing using the classical model of Grodins et al. (1967, J. Appl. Physiol. 22, 260-276), together with a prescription for the dependence of ventilation on the blood CO2 concentration, modulated by the reduced oxygen pressure (the 'Oxford fan'). The model focusses on the fast dynamics of the arterial blood CO2, and differs in this respect from our previous work which emphasised the brain CO2 concentration; in this sense our model is in fact a generalization of the conceptually simpler Mackey-Glass model

Flooding and flow reversal in annular two-phase flows.

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The role of the central chemoreceptor in causing periodic breathing.

In a previous publication (Fowler et aL, 1993), we reduced the classical cardiorespiratory control model of (Grodins et aL, 1967) to a much simpler form, which we then used to study the phenomenon of periodic breathing. In particular, cardiac output was assumed constant, and a single (constant) delay representing arterial blood transport time between lung and brain was included in the model. In this paper we extend this earlier work, both by allowing for the variability in transport delays, due to the dependence of cardiac output on blood gas concentrations, and also by including further delays in the system. In addition, we extensively discuss the physiological implications of parameter variations in the model; several novel mechanisms for periodic breathing in clinical situations are proposed. The results are discussed in the light of recent observational studies. Keywords: Periodic breathing; Cheyne-Stokes respiration; heart-rate variability*, differential-delay equations. 1

Feasibility study to determine methods of measuring the temperature of a molecular beam Final report

Molecular beam sampling technique for temperature measurement of earth thermospher

Development of an accurate wide range ultra high vacuum gauge calibration method, 29 June 1966 - 28 February 1968

Calibration method and ultrahigh vacuum components for ionization gage and mass spectromete

Development of an accurate wide range ultra high vacuum gauge calibration method

Accurate wide range ultrahigh vacuum gauge calibration method using pressure attenuation, atomic beam, and cryopumping techniques to evaluate system components and performanc

Development of reverse biased p-n junction electron emission

A cold cathode emitter of hot electrons for use as a source of electrons in vacuum gauges and mass spectrometers was developed using standard Norton electroluminescent silicon carbide p-n diodes operated under reverse bias conditions. Continued development including variations in the geometry of these emitters was carried out such that emitters with an emission efficiency (emitted current/junction current) as high as 3 x 10-0.00001 were obtained. Pulse measurements of the diode characteristics were made and showed that higher efficiency can be attained under pulse conditions probably due to the resulting lower temperatures resulting from such operation