Discovering Patterns of Interest in IP Traffic Using Cliques in Bipartite Link Streams

Studying IP traffic is crucial for many applications. We focus here on the detection of (structurally and temporally) dense sequences of interactions, that may indicate botnets or coordinated network scans. More precisely, we model a MAWI capture of IP traffic as a link streams, i.e. a sequence of interactions $(t_1 , t_2 , u, v)$ meaning that devices $u$ and $v$ exchanged packets from time $t_1$ to time $t_2$ . This traffic is captured on a single router and so has a bipartite structure: links occur only between nodes in two disjoint sets. We design a method for finding interesting bipartite cliques in such link streams, i.e. two sets of nodes and a time interval such that all nodes in the first set are linked to all nodes in the second set throughout the time interval. We then explore the bipartite cliques present in the considered trace. Comparison with the MAWILab classification of anomalous IP addresses shows that the found cliques succeed in detecting anomalous network activity

Comparing paedophile activity in different P2P systems

Peer-to-peer (P2P) systems are widely used to exchange content over the Internet. Knowledge on paedophile activity in such networks remains limited while it has important social consequences. Moreover, though there are different P2P systems in use, previous academic works on this topic focused on one system at a time and their results are not directly comparable. We design a methodology for comparing \kad and \edonkey, two P2P systems among the most prominent ones and with different anonymity levels. We monitor two \edonkey servers and the \kad network during several days and record hundreds of thousands of keyword-based queries. We detect paedophile-related queries with a previously validated tool and we propose, for the first time, a large-scale comparison of paedophile activity in two different P2P systems. We conclude that there are significantly fewer paedophile queries in \kad than in \edonkey (approximately 0.09% \vs 0.25%).Comment: Submitte

Short communication : the dissolution of UK simulant vitrified high-level-waste in groundwater solutions

Dissolution of a simulant UK nuclear waste glass containing Mg, Ca and Zn was investigated over 35 d at 50 °C in water and simulant groundwater solutions. The dissolution rates were influenced subtly by the groundwater composition, following the trend, from least to most durable: clay > water > granite ≈ saline. Solutions were rapidly silica saturated but boron dissolution rates continued to increase. This is hypothesised to be due to the formation of secondary Mg-silicate precipitates, preventing the formation of a passivating silica gel layer and allowing glass dissolution to proceed at close to the maximum rate

New Antibody-Free Mass Spectrometry-Based Quantification Reveals That C9ORF72 Long Protein Isoform Is Reduced in the Frontal Cortex of Hexanucleotide-Repeat Expansion Carriers

Frontotemporal dementia (FTD) is a fatal neurodegenerative disease characterized by behavioral and language disorders. The main genetic cause of FTD is an intronic hexanucleotide repeat expansion (G4C2)n in the C9ORF72 gene. A loss of function of the C9ORF72 protein associated with the allele-specific reduction of C9ORF72 expression is postulated to contribute to the disease pathogenesis. To better understand the contribution of the loss of function to the disease mechanism, we need to determine precisely the level of reduction in C9ORF72 long and short isoforms in brain tissue from patients with C9ORF72 mutations. In this study, we developed a sensitive and robust mass spectrometry (MS) method for quantifying C9ORF72 isoform levels in human brain tissue without requiring antibody or affinity reagent. An optimized workflow based on surfactant-aided protein extraction and pellet digestion was established for optimal recovery of the two isoforms in brain samples. Signature peptides, common or specific to the isoforms, were targeted in brain extracts by multiplex MS through the parallel reaction monitoring mode on a Quadrupole–Orbitrap high resolution mass spectrometer. The assay was successfully validated and subsequently applied to frontal cortex brain samples from a cohort of FTD patients with C9ORF72 mutations and neurologically normal controls without mutations. We showed that the C9ORF72 short isoform in the frontal cortices is below detection threshold in all tested individuals and the C9ORF72 long isoform is significantly decreased in C9ORF72 mutation carriers

Etude du système Hxu d'acquisition de l'hème de l'hémopexine de Haemophilus influenzae

PARIS7-Bibliothèque centrale (751132105) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Amélioration du processus de gestion des requêtes au sein du département de pharmacovigilance (intégration de requêtes Ad Hoc dans le logiciel global et validé de recherches médicales)

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Le Dictionnaire de terminologie médicale MedRA (application en pharmacovigilance et outils d'amélioration de sa qualité d'utilisation)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Quantifying paedophile activity in a large P2P system

International audienceIncreasing knowledge of paedophile activity in P2P systems is a crucial societal concern, with important consequences on child protection, policy making, and internet regulation. Because of a lack of traces of P2P exchanges and rigorous analysis methodology, however, current knowledge of this activity remains very limited. We consider here a widely used P2P system, eDonkey, and focus on two key statistics: the fraction of paedophile queries entered in the system and the fraction of users who entered such queries. We collect hundreds of millions of keyword-based queries; we design a paedophile query detection tool for which we establish false positive and false negative rates using assessment by experts; with this tool and these rates, we then estimate the fraction of paedophile queries in our data; finally, we design and apply methods for quantifying users who entered such queries. We conclude that approximately 0.25% of queries are paedophile, and that more than 0.2% of users enter such queries. These statistics are by far the most precise and reliable ever obtained in this domain

Quantifying Paedophile Activity in a Large P2P System

Abstract—Increasing knowledge of paedophile activity in P2P systems is a crucial societal concern, with important consequences on child protection, policy making, and internet regulation. Because of a lack of traces of P2P exchanges and rigorous analysis methodology, however, current knowledge of this activity remains very limited. We consider here a widely used P2P system, eDonkey, and focus on two key statistics: the fraction of paedophile queries entered in the system and the fraction of users who entered such queries. We collect hundreds of millions of keyword-based queries; we design a paedophile query detection tool for which we establish false positive and false negative rates using assessment by experts; with this tool and these rates, we then estimate the fraction of paedophile queries in our data; finally, we design and apply methods for quantifying users who entered such queries. We conclude that approximately 0.25 % of queries are paedophile, and that more than 0.2 % of users enter such queries. These statistics are by far the most precise and reliable ever obtained in this domain. I